PycisTarget on human cerebellum DARs and topics

[1]:

%matplotlib inline
import pycistarget
pycistarget.__version__

[1]:

'1.0.1.dev29+g95fd9fb'

pycisTarget is a python module that allows to perform motif enrichment analysis and derive genome-wide cistromes implementing cisTarget (Herrmann et al., 2012; Imrichova et al., 2015). In addition, de novo cistromes can also be derived (via Homer (Heinz et al., 2010)) and pycisTarget also includes a novel approach to derive differentially enriched motifs and cistromes between one or more groups of regions, named Differentially Enriched Motifs (DEM).

In this tutorial we will show how to obtain cistromes from topics and DARs using cisTarget and DEM. For more information on how to use Homer, take a look to the full tutorial, and within the SCENIC+ workflow, take a look to the wrapper function.

1. Deriving cistromes using topics with cisTarget

A. Loading your region sets

pycisTarget uses as input a dictionary containing the region set name as label and regions (as pyranges) as values. We will start by loading the binarized topics (see pycisTopic - Human cerebellum tutorial).

[2]:

# Load region binarized topics
import pickle
infile = open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistopic/topic_binarization/binarized_topic_region.pkl', 'rb')
binarized_topic_region = pickle.load(infile)
infile.close()

[3]:

import pyranges as pr
from pycistarget.utils import *
region_sets = {key: pr.PyRanges(region_names_to_coordinates(binarized_topic_region[key].index.tolist())) for key in binarized_topic_region.keys()}

B. Create cisTarget database

To run cisTarget you will need to provide a ranking database (that is, a feather file with a dataframe with motifs as rows, genomic regions as columns and their ranked position [based on cis-regulatory module (CRM) score (Frith et al., 2003)] as values). We provide those databases for human (hg38, hg19), mouse (mm10, mm9) and fly (dm3, dm6) at https://resources.aertslab.org/cistarget/.

In addition, if you want to use other regions or genomes to build your databases, we provide a step-by-step tutorial and scripts at https://github.com/aertslab/create_cisTarget_databases. Below you can find the basic steps to do so:

[ ]:

%%bash
#### Variables
genome_fasta = '/staging/leuven/stg_00002/lcb/resources/human/hg38/hg38.fa'
region_bed = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistopic/consensus_peak_calling/consensus_regions.bed'
region_fasta = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistopic/consensus_peak_calling/consensus_regions.fa'
database_suffix = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/dbs/human_brain'
path_to_motif_collection = 'PATH_TO_MOTIF_COLLECTION_IN_CLUSTER_BUSTER_FORMAT'
motif_list = 'PATH_TO_FILE_WITH_MOTIFS_TO_SCORE'
n_cpu = '20'
#### Get fasta sequences
module load BEDTools # In our system, load BEDTools
bedtools getfasta -fi ${genome_fasta} -bed ${region_bed} > ${region_fasta}
#### Activate environment
my_conda_initialize # In our system, initialize conda
conda activate /staging/leuven/stg_00002/lcb/ghuls/software/miniconda3/envs/create_cistarget_databases
#### Set ${create_cistarget_databases_dir} to https://github.com/aertslab/create_cisTarget_databases
create_cistarget_databases_dir='/staging/leuven/stg_00002/lcb/ghuls/software/create_cisTarget_databases'
#### Score the motifs - This will generate the scores database we will use later on for DEM
${create_cistarget_databases_dir}/create_cistarget_motif_databases.py \
-f ${region_fasta} \
-M ${path_to_motif_collection} \
-m ${motif_list} \
-o ${database_suffix} \
-t ${n_cpu} \
-l \
-s 555
done
#### Create rankings
motifs_vs_regions_scores_feather = 'PATH_TO_MOTIFS_VS_REGIONS_SCORES_DATABASE'
${create_cistarget_databases_dir}/convert_motifs_or_tracks_vs_regions_or_genes_scores_to_rankings_cistarget_dbs.py -i ${database_suffix}.motifs_vs_regions.scores.feather -s 555

C. cisTarget

For running cisTarget there are some relevant parameters:

ctx_db: Path to the cisTarget database to use, or a preloaded cisTargetDatabase object (using the same region sets to be analyzed)
region_sets: The input sets of regions
specie: Specie to which region coordinates and database belong to. To annotate motifs to TFs using cisTarget annotations, possible values are ‘mus_musculus’, ‘homo_sapiens’ or ‘drosophila_melanogaster’. If any other value, motifs will not be annotated to a TF unless providing a customized annotation.
fraction_overlap: Minimum overlap fraction (in any direction) to map input regions to regions in the database. Default: 0.4.
auc_threshold: Threshold to calculate the AUC. For human and mouse we recommend to set it to 0.005 (default), for fly to 0.01.
nes_threshold: NES threshold to calculate the motif significant. Default: 3.0
rank_threshold: Percentage of regions to use as maximum rank to take into account for the region enrichment recovery curve. By default, we use 5% of the total number of regions in the database.
annotation: Annotation to use to form the cistromes. Here we will only use the direct annotation as example. Default: [‘Direct_annot’, ‘Motif_similarity_annot’, ‘Orthology_annot’, ‘Motif_similarity_and_Orthology_annot’]
n_cpu: Number of cpus to use during calculations.

[4]:

# Load cistarget functions
from pycistarget.motif_enrichment_cistarget import *

[5]:

# Preload db, you can also just provide the path to the db. Preloading the database is useful if you want to test different parameters.
# This will take some time depending on the size of your database
db = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/dbs/human_brain.regions_vs_motifs.rankings.feather'
ctx_db = cisTargetDatabase(db, region_sets)
# Remove dbcorr motifs (only if using cisTarget v9)
ctx_db.db_rankings = ctx_db.db_rankings[~ctx_db.db_rankings.index.str.contains("dbcorr")]

2021-08-12 12:27:28,368 cisTarget    INFO     Reading cisTarget database

[6]:

# Run
cistarget_dict = run_cistarget(ctx_db = ctx_db,
                               region_sets = region_sets,
                               specie = 'homo_sapiens',
                               annotation_version = 'v9nr_clust', #Use v10nr_clust for the latest motif collection
                               auc_threshold = 0.005,
                               nes_threshold = 3.0,
                               rank_threshold = 0.05,
                               annotation = ['Direct_annot', 'Orthology_annot'],
                               n_cpu = 1,
                               _temp_dir='/scratch/leuven/313/vsc31305/ray_spill')

2021-08-12 12:40:36,427 cisTarget    INFO     Running cisTarget for Topic1 which has 12394 regions
2021-08-12 12:40:45,803 cisTarget    INFO     Annotating motifs for Topic1
2021-08-12 12:40:47,593 cisTarget    INFO     Getting cistromes for Topic1
2021-08-12 12:40:47,807 cisTarget    INFO     Running cisTarget for Topic2 which has 8915 regions
2021-08-12 12:40:53,352 cisTarget    INFO     Annotating motifs for Topic2
2021-08-12 12:40:54,780 cisTarget    INFO     Getting cistromes for Topic2
2021-08-12 12:40:54,970 cisTarget    INFO     Running cisTarget for Topic3 which has 3593 regions
2021-08-12 12:40:59,393 cisTarget    INFO     Annotating motifs for Topic3
2021-08-12 12:41:00,740 cisTarget    INFO     Getting cistromes for Topic3
2021-08-12 12:41:00,926 cisTarget    INFO     Running cisTarget for Topic4 which has 6046 regions
2021-08-12 12:41:05,573 cisTarget    INFO     Annotating motifs for Topic4
2021-08-12 12:41:06,857 cisTarget    INFO     Getting cistromes for Topic4
2021-08-12 12:41:06,941 cisTarget    INFO     Running cisTarget for Topic5 which has 3182 regions
2021-08-12 12:41:11,564 cisTarget    INFO     Annotating motifs for Topic5
2021-08-12 12:41:12,936 cisTarget    INFO     Getting cistromes for Topic5
2021-08-12 12:41:13,105 cisTarget    INFO     Running cisTarget for Topic6 which has 11592 regions
2021-08-12 12:41:19,003 cisTarget    INFO     Annotating motifs for Topic6
2021-08-12 12:41:20,391 cisTarget    INFO     Getting cistromes for Topic6
2021-08-12 12:41:20,547 cisTarget    INFO     Running cisTarget for Topic7 which has 1457 regions
2021-08-12 12:41:25,347 cisTarget    INFO     Annotating motifs for Topic7
2021-08-12 12:41:26,768 cisTarget    INFO     Getting cistromes for Topic7
2021-08-12 12:41:27,124 cisTarget    INFO     Running cisTarget for Topic8 which has 4527 regions
2021-08-12 12:41:31,627 cisTarget    INFO     Annotating motifs for Topic8
2021-08-12 12:41:32,912 cisTarget    INFO     Getting cistromes for Topic8
2021-08-12 12:41:33,047 cisTarget    INFO     Running cisTarget for Topic9 which has 4963 regions
2021-08-12 12:41:37,546 cisTarget    INFO     Annotating motifs for Topic9
2021-08-12 12:41:38,814 cisTarget    INFO     Getting cistromes for Topic9
2021-08-12 12:41:38,916 cisTarget    INFO     Running cisTarget for Topic10 which has 1357 regions
2021-08-12 12:41:43,849 cisTarget    INFO     Annotating motifs for Topic10
2021-08-12 12:41:45,246 cisTarget    INFO     Getting cistromes for Topic10
2021-08-12 12:41:45,635 cisTarget    INFO     Running cisTarget for Topic11 which has 1462 regions
2021-08-12 12:41:50,439 cisTarget    INFO     Annotating motifs for Topic11
2021-08-12 12:41:51,944 cisTarget    INFO     Getting cistromes for Topic11
2021-08-12 12:41:52,338 cisTarget    INFO     Running cisTarget for Topic12 which has 1612 regions
2021-08-12 12:41:57,153 cisTarget    INFO     Annotating motifs for Topic12
2021-08-12 12:41:58,675 cisTarget    INFO     Getting cistromes for Topic12
2021-08-12 12:41:59,004 cisTarget    INFO     Running cisTarget for Topic13 which has 3148 regions
2021-08-12 12:42:04,100 cisTarget    INFO     Annotating motifs for Topic13
2021-08-12 12:42:05,578 cisTarget    INFO     Getting cistromes for Topic13
2021-08-12 12:42:06,046 cisTarget    INFO     Running cisTarget for Topic14 which has 3043 regions
2021-08-12 12:42:10,967 cisTarget    INFO     Annotating motifs for Topic14
2021-08-12 12:42:12,388 cisTarget    INFO     Getting cistromes for Topic14
2021-08-12 12:42:12,673 cisTarget    INFO     Running cisTarget for Topic15 which has 11747 regions
2021-08-12 12:42:18,721 cisTarget    INFO     Annotating motifs for Topic15
2021-08-12 12:42:20,233 cisTarget    INFO     Getting cistromes for Topic15
2021-08-12 12:42:20,392 cisTarget    INFO     Running cisTarget for Topic16 which has 8674 regions
2021-08-12 12:42:26,128 cisTarget    INFO     Annotating motifs for Topic16
2021-08-12 12:42:27,664 cisTarget    INFO     Getting cistromes for Topic16
2021-08-12 12:42:27,850 cisTarget    INFO     Running cisTarget for Topic17 which has 4047 regions
2021-08-12 12:42:32,849 cisTarget    INFO     Annotating motifs for Topic17
2021-08-12 12:42:34,354 cisTarget    INFO     Getting cistromes for Topic17
2021-08-12 12:42:34,693 cisTarget    INFO     Running cisTarget for Topic18 which has 6652 regions
2021-08-12 12:42:40,401 cisTarget    INFO     Annotating motifs for Topic18
2021-08-12 12:42:42,006 cisTarget    INFO     Getting cistromes for Topic18
2021-08-12 12:42:42,242 cisTarget    INFO     Running cisTarget for Topic19 which has 7816 regions
2021-08-12 12:42:47,268 cisTarget    INFO     Annotating motifs for Topic19
2021-08-12 12:42:48,585 cisTarget    INFO     Getting cistromes for Topic19
2021-08-12 12:42:48,702 cisTarget    INFO     Running cisTarget for Topic20 which has 12459 regions
2021-08-12 12:42:54,914 cisTarget    INFO     Annotating motifs for Topic20
2021-08-12 12:42:56,420 cisTarget    INFO     Getting cistromes for Topic20
2021-08-12 12:42:56,588 cisTarget    INFO     Running cisTarget for Topic21 which has 13030 regions
2021-08-12 12:43:03,214 cisTarget    INFO     Annotating motifs for Topic21
2021-08-12 12:43:04,905 cisTarget    INFO     Getting cistromes for Topic21
2021-08-12 12:43:05,172 cisTarget    INFO     Running cisTarget for Topic22 which has 7150 regions
2021-08-12 12:43:11,397 cisTarget    INFO     Annotating motifs for Topic22
2021-08-12 12:43:12,934 cisTarget    INFO     Getting cistromes for Topic22
2021-08-12 12:43:13,376 cisTarget    INFO     Running cisTarget for Topic23 which has 14698 regions
2021-08-12 12:43:20,701 cisTarget    INFO     Annotating motifs for Topic23
2021-08-12 12:43:22,554 cisTarget    INFO     Getting cistromes for Topic23
2021-08-12 12:43:22,805 cisTarget    INFO     Running cisTarget for Topic24 which has 3912 regions
2021-08-12 12:43:27,950 cisTarget    INFO     Annotating motifs for Topic24
2021-08-12 12:43:29,417 cisTarget    INFO     Getting cistromes for Topic24
2021-08-12 12:43:29,845 cisTarget    INFO     Running cisTarget for Topic25 which has 3792 regions
2021-08-12 12:43:35,227 cisTarget    INFO     Annotating motifs for Topic25
2021-08-12 12:43:36,835 cisTarget    INFO     Getting cistromes for Topic25
2021-08-12 12:43:37,351 cisTarget    INFO     Running cisTarget for Topic26 which has 4118 regions
2021-08-12 12:43:42,794 cisTarget    INFO     Annotating motifs for Topic26
2021-08-12 12:43:44,507 cisTarget    INFO     Getting cistromes for Topic26
2021-08-12 12:43:45,032 cisTarget    INFO     Running cisTarget for Topic27 which has 3232 regions
2021-08-12 12:43:50,509 cisTarget    INFO     Annotating motifs for Topic27
2021-08-12 12:43:52,513 cisTarget    INFO     Getting cistromes for Topic27
2021-08-12 12:43:53,033 cisTarget    INFO     Running cisTarget for Topic28 which has 7936 regions
2021-08-12 12:43:59,641 cisTarget    INFO     Annotating motifs for Topic28
2021-08-12 12:44:01,629 cisTarget    INFO     Getting cistromes for Topic28
2021-08-12 12:44:02,034 cisTarget    INFO     Running cisTarget for Topic29 which has 11535 regions
2021-08-12 12:44:09,884 cisTarget    INFO     Annotating motifs for Topic29
2021-08-12 12:44:12,487 cisTarget    INFO     Getting cistromes for Topic29
2021-08-12 12:44:12,985 cisTarget    INFO     Running cisTarget for Topic30 which has 7097 regions
2021-08-12 12:44:19,152 cisTarget    INFO     Annotating motifs for Topic30
2021-08-12 12:44:20,935 cisTarget    INFO     Getting cistromes for Topic30
2021-08-12 12:44:21,406 cisTarget    INFO     Running cisTarget for Topic31 which has 2627 regions
2021-08-12 12:44:26,554 cisTarget    INFO     Annotating motifs for Topic31
2021-08-12 12:44:28,399 cisTarget    INFO     Getting cistromes for Topic31
2021-08-12 12:44:28,824 cisTarget    INFO     Running cisTarget for Topic32 which has 6702 regions
2021-08-12 12:44:34,276 cisTarget    INFO     Annotating motifs for Topic32
2021-08-12 12:44:35,654 cisTarget    INFO     Getting cistromes for Topic32
2021-08-12 12:44:35,747 cisTarget    INFO     Running cisTarget for Topic33 which has 5992 regions
2021-08-12 12:44:40,865 cisTarget    INFO     Annotating motifs for Topic33
2021-08-12 12:44:42,261 cisTarget    INFO     Getting cistromes for Topic33
2021-08-12 12:44:42,384 cisTarget    INFO     Running cisTarget for Topic34 which has 10585 regions
2021-08-12 12:44:48,746 cisTarget    INFO     Annotating motifs for Topic34
2021-08-12 12:44:50,320 cisTarget    INFO     Getting cistromes for Topic34
2021-08-12 12:44:50,614 cisTarget    INFO     Running cisTarget for Topic35 which has 1856 regions
2021-08-12 12:44:55,440 cisTarget    INFO     Annotating motifs for Topic35
2021-08-12 12:44:57,035 cisTarget    INFO     Getting cistromes for Topic35
2021-08-12 12:44:57,476 cisTarget    INFO     Running cisTarget for Topic36 which has 7101 regions
2021-08-12 12:45:03,528 cisTarget    INFO     Annotating motifs for Topic36
2021-08-12 12:45:05,193 cisTarget    INFO     Getting cistromes for Topic36
2021-08-12 12:45:05,533 cisTarget    INFO     Running cisTarget for Topic37 which has 4040 regions
2021-08-12 12:45:10,509 cisTarget    INFO     Annotating motifs for Topic37
2021-08-12 12:45:11,830 cisTarget    INFO     Getting cistromes for Topic37
2021-08-12 12:45:12,168 cisTarget    INFO     Running cisTarget for Topic38 which has 13567 regions
2021-08-12 12:45:19,228 cisTarget    INFO     Annotating motifs for Topic38
2021-08-12 12:45:20,942 cisTarget    INFO     Getting cistromes for Topic38
2021-08-12 12:45:21,170 cisTarget    INFO     Running cisTarget for Topic39 which has 3935 regions
2021-08-12 12:45:26,459 cisTarget    INFO     Annotating motifs for Topic39
2021-08-12 12:45:28,126 cisTarget    INFO     Getting cistromes for Topic39
2021-08-12 12:45:28,426 cisTarget    INFO     Running cisTarget for Topic40 which has 10102 regions
2021-08-12 12:45:35,528 cisTarget    INFO     Annotating motifs for Topic40
2021-08-12 12:45:37,568 cisTarget    INFO     Getting cistromes for Topic40
2021-08-12 12:45:38,005 cisTarget    INFO     Done!

[7]:

# Save
import pickle
with open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/topics/topic_cistarget_dict.pkl', 'wb') as f:
  pickle.dump(cistarget_dict, f)

We can load the results for exploration.

[8]:

# Load
import pickle
infile = open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/topics/topic_cistarget_dict.pkl', 'rb')
cistarget_dict = pickle.load(infile)
infile.close()

To visualize motif enrichment results, we can use the cisTarget_results() function:

[57]:

cistarget_results(cistarget_dict, name='Topic21')

[57]:

	Region_set	Direct_annot	Orthology_annot	NES	AUC	Rank_at_max	Motif_hits
cisbp__M0416	Topic21	NaN	EGR2	7.788373	0.006863	21780.0	1177
jaspar__MA0491.1	Topic21	JUND	NaN	7.322481	0.006596	21692.0	1247
cisbp__M4526	Topic21	SMARCC1	NaN	7.137253	0.006489	21786.0	1174
taipale_cyt_meth__JUN_NATGACTCATN_FL_meth	Topic21	JUN	NaN	6.721687	0.006251	21787.0	1211
cisbp__M6230	Topic21	FOSL2	NaN	6.647670	0.006208	21672.0	1193
hocomoco__FOSL2_MOUSE.H11MO.0.A	Topic21	NaN	FOSL2	6.621156	0.006193	21743.0	1197
taipale_tf_pairs__BACH1_ATGACTCAT_HT	Topic21	BACH1	NaN	6.607470	0.006185	21790.0	1224
metacluster_35.5	Topic21	MEF2A, SMARCC1, JUNB, FOSB, FOS, ATF3, SMARCA4, MEF2C, FOSL2, JUN, STAT3, GATA2, MYC, FOSL1, BACH2, JUND, NFE2, RCOR1, BACH1, JDP2	FOSL1, JUNB, JUND, FOSB, FOS, FOSL2, JUN, JDP2, BATF	6.499758	0.006124	21776.0	1279
jaspar__MA0303.1	Topic21	NaN	NaN	6.415368	0.006075	21783.0	1209
flyfactorsurvey__kay_Jra_SANGER_5_FBgn0001291	Topic21	NaN	JUN, JUND, JUNB	6.281511	0.005998	21764.0	1213
transfac_pro__M01267	Topic21	FOSL1	NaN	6.253953	0.005982	21790.0	1127
flyfactorsurvey__klu_SOLEXA_F2-4	Topic21	NaN	WT1	6.251560	0.005981	21704.0	1086
jaspar__MA0477.1	Topic21	FOSL1	NaN	6.248737	0.005979	21521.0	1186
transfac_pro__M08946	Topic21	FOS	NaN	6.244931	0.005977	21771.0	1205
metacluster_35.6	Topic21	JUNB, BCL3, CEBPB, JUND, EP300, NFIC, TRIM28, FOSB, FOS, FOSL2, JUN, FOSL1, BATF, STAT3	JUND, ATF3, FOSB, JUNB	6.210194	0.005957	21759.0	1221
yetfasco__YEL009C_1363	Topic21	NaN	NaN	6.113222	0.005902	21523.0	1208
yetfasco__YER064C_2094	Topic21	NaN	NaN	6.074618	0.005880	21773.0	1195
hocomoco__JUNB_HUMAN.H11MO.0.A	Topic21	JUNB	NaN	6.050068	0.005865	21731.0	1170
cisbp__M6467	Topic21	SMARCC1	NaN	6.029446	0.005854	21643.0	1068
cisbp__M5589	Topic21	JDP2	NaN	6.024720	0.005851	21646.0	1178
cisbp__M0414	Topic21	NaN	EGR3	5.815004	0.005731	21768.0	1124
taipale_cyt_meth__JUNB_NATGASTCAYN_eDBD_meth	Topic21	JUNB	NaN	5.767378	0.005703	21632.0	1168
yetfasco__YIL056W_2091	Topic21	NaN	NaN	5.529245	0.005567	21628.0	1157
metacluster_35.2	Topic21	JUN, BATF	NaN	5.458726	0.005526	21733.0	1096
cisbp__M5216	Topic21	NaN	EGR2, EGR3, EGR4	5.455289	0.005524	21734.0	1105
cisbp__M2308	Topic21	NaN	RFX1	5.341624	0.005459	7707.0	394
transfac_pro__M07410	Topic21	RFX2	NaN	5.314926	0.005444	14901.0	646
metacluster_53.6	Topic21	SREBF1, TEAD1, RFX3, MXI1, TPPP, RFX4, NELFB, ZBTB7B, MAX, RFX1, RFX5, RFX2, RFXAP, RFXANK	RFX3, RFX7, RFX4, RFX6, RFX1, RFX5, RFX2, RFX8	5.131724	0.005338	7136.0	372
swissregulon__sacCer__RFX1	Topic21	NaN	RFX3, RFX7, RFX4, RFX6, RFX1, RFX5, RFX2, RFX8	4.974421	0.005248	19294.0	768
flyfactorsurvey__klu_SOLEXA_5_FBgn0013469	Topic21	NaN	WT1	4.790850	0.005143	21747.0	1068
cisbp__M3830	Topic21	RFX1	NaN	4.672766	0.005075	7654.0	339
elemento__ACGCCCAC	Topic21	NaN	NaN	4.667120	0.005072	10204.0	443
metacluster_63.1	Topic21	ARID3A, JUNB, IRF4, FOXM1, TRIM28, FOSB, FOS, ATF3, MAFG, BCL11A, SMARCB1, SMARCA4, NRF1, MAFK, JUN, MAFB, STAT3, NFE2L2, EP300, MAFF, NFE2L1, TBL1XR1, FOSL1, BACH2, RELA, NFE2L3, MTA3, JUND, NFE2, MAF, RCOR1, TCF12, BACH1	FOS	4.605193	0.005036	21655.0	1009
taipale_cyt_meth__RFX4_NGTTRCCATGGYAACN_eDBD	Topic21	RFX4	NaN	4.547501	0.005003	9394.0	426
metacluster_35.7	Topic21	JUNB, JUND, FOSB, FOS, FOSL2, JUN, FOSL1	FOS	4.402596	0.004920	21766.0	1075
cisbp__M5368	Topic21	EGR2	NaN	4.309737	0.004867	21783.0	1142
cisbp__M6199	Topic21	EGR2	NaN	4.240445	0.004827	21739.0	1028
metacluster_54.22	Topic21	EGR3, ZNF599	NaN	4.230810	0.004821	20952.0	878
taipale_cyt_meth__RFX2_NGTTRCCATGGYAACN_eDBD_meth	Topic21	RFX2	NaN	4.179501	0.004792	7737.0	365
hocomoco__RFX2_HUMAN.H11MO.1.A	Topic21	RFX2	NaN	4.125307	0.004761	7140.0	332
cisbp__M3178	Topic21	EGR3	NaN	4.099898	0.004746	21735.0	1035
cisbp__M5215	Topic21	NaN	EGR2, EGR3, EGR4	4.075839	0.004733	21309.0	967
cisbp__M3167	Topic21	EGR1	NaN	3.840837	0.004598	21745.0	1046
metacluster_5.5	Topic21	NaN	NaN	3.835866	0.004595	12431.0	519
metacluster_54.26	Topic21	NaN	NaN	3.736623	0.004538	21606.0	889
cisbp__M5366	Topic21	EGR1	NaN	3.726742	0.004532	21782.0	1015
cisbp__M6003	Topic21	NaN	EGR3	3.672364	0.004501	21610.0	1000
metacluster_34.15	Topic21	STAT5A, JUND, FOSL2, BATF, STAT3	BATF	3.661869	0.004495	21771.0	1016
swissregulon__hs__NFE2.p2	Topic21	NFE2	NaN	3.611972	0.004466	21550.0	977
metacluster_54.9	Topic21	EGR3	WT1	3.433373	0.004364	21732.0	1044
transfac_pro__M07374	Topic21	BACH1	NaN	3.373840	0.004330	21489.0	870
metacluster_74.17	Topic21	NaN	NaN	3.359662	0.004322	10995.0	433
cisbp__M0434	Topic21	NaN	ZSCAN4	3.357514	0.004320	14516.0	564
cisbp__M6156	Topic21	BACH1	NaN	3.328116	0.004303	20265.0	776
hdpi__HES5	Topic21	HES5	NaN	3.319830	0.004299	1384.0	73
cisbp__M5370	Topic21	EGR4	NaN	3.293132	0.004283	21782.0	919
metacluster_54.12	Topic21	EGR2, EGR3, EGR1, EGR4	EGR3, WT1, EGR1	3.278157	0.004275	21140.0	1005
hocomoco__EGR2_HUMAN.H11MO.0.A	Topic21	EGR2	NaN	3.276561	0.004274	21721.0	912
cisbp__M0390	Topic21	NaN	NaN	3.239675	0.004253	21300.0	786
metacluster_53.5	Topic21	RFX3, RFX4, RFX1, RFX2, RFXAP	RFX1, RFX2, RFX6, RFX3	3.197327	0.004228	9404.0	422
metacluster_34.44	Topic21	NaN	NaN	3.147000	0.004200	3744.0	167
transfac_pro__M08800	Topic21	ARNT	NaN	3.143747	0.004198	6568.0	280
cisbp__M4575	Topic21	RFX5	NaN	3.139205	0.004195	15159.0	601
metacluster_13.6	Topic21	HEY2, TFEB, ARNTL2, MNT, ENO1, CREB3L4, HEY1, USF1, MAX, USF2, ID1, MITF, ARNT2, BHLHE40, BHLHE41, TFE3, MXI1, OLIG2, MXD4, HEYL, CLOCK, MYCN, ARNTL, HES6, OLIG1, CREB3L1, MXD3, CREB3, MYC, ARNT, ATF6B, MLXIPL, NPAS2	MYCN, NPAS2, HES6, MXI1, CLOCK, MYCL, CREB3L1, MAX, MYC, ARNT, CREB3L2, ID2	3.122819	0.004186	1754.0	89
metacluster_54.13	Topic21	EGR2	EGR1	3.119382	0.004184	21111.0	964
metacluster_54.10	Topic21	EGR4, EGR2, KLF11, EGR3, PURA, WT1, EGR1	EGR4, EGR2, EGR3, WT1, EGR1	3.115331	0.004181	21779.0	991
metacluster_5.22	Topic21	NaN	NaN	3.107782	0.004177	1256.0	73
cisbp__M0170	Topic21	NaN	NaN	3.106002	0.004176	9391.0	372
taipale_tf_pairs__GCM2_MAX_NTRNGGGNNNCACGTG_CAP_repr	Topic21	GCM2, MAX	NaN	3.092745	0.004168	18423.0	699
hocomoco__BATF_MOUSE.H11MO.0.A	Topic21	NaN	BATF	3.089124	0.004166	16898.0	730
transfac_pro__M07911	Topic21	NaN	SP4, SP3, SP2, SP1	3.052729	0.004145	21449.0	900
metacluster_45.11	Topic21	NaN	NaN	3.050765	0.004144	18621.0	770
metacluster_34.14	Topic21	BCL3, CEBPB, EP300, JUND, SETDB1, SMARCA4, TRIM28, CBX3, ATF2, JUN, RFX5	ZNF691	3.048371	0.004143	21285.0	959
metacluster_35.8	Topic21	NaN	NaN	3.048187	0.004143	21669.0	945
cisbp__M4086	Topic21	USF1	NaN	3.045978	0.004142	1685.0	85
hocomoco__RFX1_HUMAN.H11MO.0.B	Topic21	RFX1	NaN	3.013388	0.004123	10521.0	450

This table can also be easily exported to a html file:

[58]:

for x in range(1, len(cistarget_dict)+1):
    out_file = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/topics/Topic'+ str(x) + '.html'
    cistarget_dict['Topic'+ str(x)].motif_enrichment.to_html(open(out_file, 'w'), escape=False, col_space=80)

In addition, we can also access cistromes directly. Cistromes with the ‘_extended’ annotation include regions that contain a motif annotated to the TF by orthology in this case.

[59]:

cistarget_dict['Topic21'].cistromes['Region_set'].keys()

[59]:

dict_keys(['ARID3A_(1009r)', 'HEY1_(89r)', 'FOS_(2206r)', 'MITF_(89r)', 'ARNT2_(89r)', 'EGR3_(2957r)', 'JUN_(2662r)', 'CLOCK_(89r)', 'MAFF_(1009r)', 'CREB3L1_(89r)', 'CREB3_(89r)', 'FOSL1_(2261r)', 'SREBF1_(372r)', 'NPAS2_(89r)', 'MTA3_(1009r)', 'RFXAP_(616r)', 'HEY2_(89r)', 'MEF2A_(1279r)', 'STAT5A_(1016r)', 'IRF4_(1009r)', 'ENO1_(89r)', 'TRIM28_(1941r)', 'ID1_(89r)', 'BCL11A_(1009r)', 'BATF_(1914r)', 'BHLHE40_(89r)', 'RFX3_(616r)', 'EGR4_(1882r)', 'ZBTB7B_(372r)', 'FOSL2_(2102r)', 'STAT3_(2023r)', 'NFE2L2_(1009r)', 'HES6_(89r)', 'OLIG1_(89r)', 'GATA2_(1279r)', 'MYC_(1358r)', 'ATF6B_(89r)', 'BACH2_(1661r)', 'KLF11_(991r)', 'BACH1_(2508r)', 'TFEB_(89r)', 'MNT_(89r)', 'NFIC_(1221r)', 'ATF3_(1661r)', 'MAX_(1123r)', 'SMARCB1_(1009r)', 'EGR1_(2291r)', 'TFE3_(89r)', 'TPPP_(372r)', 'RFX1_(877r)', 'MYCN_(89r)', 'ARNTL_(89r)', 'CEBPB_(1680r)', 'EP300_(1941r)', 'NFE2L1_(1009r)', 'MLXIPL_(89r)', 'RELA_(1009r)', 'GCM2_(699r)', 'NFE2L3_(1009r)', 'NFE2_(2023r)', 'MAF_(1009r)', 'SETDB1_(959r)', 'SMARCC1_(1809r)', 'ARNTL2_(89r)', 'JUNB_(2270r)', 'BCL3_(1680r)', 'FOXM1_(1009r)', 'CREB3L4_(89r)', 'FOSB_(2010r)', 'USF1_(132r)', 'NELFB_(372r)', 'MAFG_(1009r)', 'USF2_(89r)', 'RFX5_(1709r)', 'RFX2_(992r)', 'BHLHE41_(89r)', 'MXI1_(456r)', 'SMARCA4_(2012r)', 'ZNF599_(878r)', 'NRF1_(1009r)', 'CBX3_(959r)', 'MAFK_(1009r)', 'HES5_(73r)', 'OLIG2_(89r)', 'MEF2C_(1279r)', 'MXD4_(89r)', 'HEYL_(89r)', 'MAFB_(1009r)', 'PURA_(991r)', 'WT1_(991r)', 'TEAD1_(372r)', 'EGR2_(2719r)', 'ATF2_(959r)', 'MXD3_(89r)', 'ARNT_(310r)', 'TBL1XR1_(1009r)', 'JUND_(2598r)', 'RCOR1_(1661r)', 'TCF12_(1009r)', 'RFX4_(771r)', 'JDP2_(1552r)', 'RFXANK_(372r)', 'ARID3A_extended_(1009r)', 'HEY1_extended_(89r)', 'FOS_extended_(2206r)', 'MITF_extended_(89r)', 'ARNT2_extended_(89r)', 'ZNF691_extended_(959r)', 'MYCL_extended_(89r)', 'EGR3_extended_(3668r)', 'SP2_extended_(900r)', 'JUN_extended_(2782r)', 'CLOCK_extended_(89r)', 'MAFF_extended_(1009r)', 'CREB3L1_extended_(89r)', 'CREB3_extended_(89r)', 'FOSL1_extended_(2261r)', 'SREBF1_extended_(372r)', 'NPAS2_extended_(89r)', 'MTA3_extended_(1009r)', 'RFXAP_extended_(616r)', 'HEY2_extended_(89r)', 'MEF2A_extended_(1279r)', 'STAT5A_extended_(1016r)', 'IRF4_extended_(1009r)', 'ENO1_extended_(89r)', 'TRIM28_extended_(1941r)', 'ID1_extended_(89r)', 'BCL11A_extended_(1009r)', 'BATF_extended_(2216r)', 'BHLHE40_extended_(89r)', 'RFX3_extended_(1050r)', 'EGR4_extended_(2329r)', 'ZBTB7B_extended_(372r)', 'FOSL2_extended_(2158r)', 'ID2_extended_(89r)', 'STAT3_extended_(2023r)', 'NFE2L2_extended_(1009r)', 'HES6_extended_(89r)', 'OLIG1_extended_(89r)', 'GATA2_extended_(1279r)', 'MYC_extended_(1358r)', 'ATF6B_extended_(89r)', 'SP4_extended_(900r)', 'BACH2_extended_(1661r)', 'KLF11_extended_(991r)', 'CREB3L2_extended_(89r)', 'BACH1_extended_(2508r)', 'TFEB_extended_(89r)', 'MNT_extended_(89r)', 'RFX7_extended_(834r)', 'NFIC_extended_(1221r)', 'ATF3_extended_(1754r)', 'MAX_extended_(1123r)', 'SMARCB1_extended_(1009r)', 'EGR1_extended_(2637r)', 'TFE3_extended_(89r)', 'TPPP_extended_(372r)', 'RFX6_extended_(1050r)', 'RFX1_extended_(1277r)', 'MYCN_extended_(89r)', 'ARNTL_extended_(89r)', 'CEBPB_extended_(1680r)', 'EP300_extended_(1941r)', 'NFE2L1_extended_(1009r)', 'MLXIPL_extended_(89r)', 'RFX8_extended_(834r)', 'RELA_extended_(1009r)', 'GCM2_extended_(699r)', 'NFE2L3_extended_(1009r)', 'NFE2_extended_(2023r)', 'MAF_extended_(1009r)', 'SETDB1_extended_(959r)', 'SMARCC1_extended_(1809r)', 'ARNTL2_extended_(89r)', 'JUNB_extended_(2403r)', 'BCL3_extended_(1680r)', 'FOXM1_extended_(1009r)', 'CREB3L4_extended_(89r)', 'FOSB_extended_(2010r)', 'USF1_extended_(132r)', 'NELFB_extended_(372r)', 'MAFG_extended_(1009r)', 'USF2_extended_(89r)', 'RFX5_extended_(2083r)', 'RFX2_extended_(1337r)', 'BHLHE41_extended_(89r)', 'MXI1_extended_(456r)', 'SMARCA4_extended_(2012r)', 'ZNF599_extended_(878r)', 'NRF1_extended_(1009r)', 'CBX3_extended_(959r)', 'MAFK_extended_(1009r)', 'HES5_extended_(73r)', 'OLIG2_extended_(89r)', 'MEF2C_extended_(1279r)', 'MXD4_extended_(89r)', 'HEYL_extended_(89r)', 'MAFB_extended_(1009r)', 'PURA_extended_(991r)', 'WT1_extended_(2378r)', 'TEAD1_extended_(372r)', 'EGR2_extended_(3244r)', 'ZSCAN4_extended_(564r)', 'ATF2_extended_(959r)', 'MXD3_extended_(89r)', 'ARNT_extended_(310r)', 'TBL1XR1_extended_(1009r)', 'SP3_extended_(900r)', 'SP1_extended_(900r)', 'JUND_extended_(2718r)', 'RCOR1_extended_(1661r)', 'TCF12_extended_(1009r)', 'RFX4_extended_(1168r)', 'JDP2_extended_(1552r)', 'RFXANK_extended_(372r)'])

D. DEM

For running DEM there are some relevant parameters:

dem_db: Path to the DEM database to use, or a preloaded DEMDatabase object (using the same region sets to be analyzed)
region_sets: The input sets of regions
specie: Specie to which region coordinates and database belong to. To annotate motifs to TFs using cisTarget annotations, possible values are ‘mus_musculus’, ‘homo_sapiens’ or ‘drosophila_melanogaster’. If any other value, motifs will not be annotated to a TF unless providing a customized annotation.
contrasts: Type of contrast to perform. If ‘Other’, background regions will be taken from other region sets; if ‘Shuffle’ the background will consist of the scores on shuffled input sequences. You can also provide a list specifying the specific contrasts to make. We will show some examples of these modalities below. When using ‘Shuffle’, the cluster-buster path, the genome fasta and the path to the folder with the motifs to score (cluster-buster format) has to be provided.
fraction_overlap: Minimum overlap fraction (in any direction) to map input regions to regions in the database. Default: 0.4.
max_bg_regions: Maximum number of background regions to use. Default: None (all regions).
adjpval_thr: Maximum adjusted p-value to select motifs. Default: 0.05
log2fc_thr: Minimum LogFC between the regions set and te background to consider the motif as differentially enriched. Default: 1.
mean_fg_thr: Minimum mean CRM value in the foreground (region set) to consider the motif differentially enriched. Default: 0
motif_hit_thr: Minimum CRM value to consider a region a motif hit. If None (default), an optimal threshold will be calculated per motif by comparing foreground and background.
annotation: Annotation to use to form the cistromes. Here we will only use the direct annotation as example. Default: [‘Direct_annot’, ‘Motif_similarity_annot’, ‘Orthology_annot’, ‘Motif_similarity_and_Orthology_annot’]
n_cpu: Number of cpus to use during calculations.

In this example, we will the score database previously generated. For more information on how to create cisTarget databases, please visit: https://github.com/aertslab/create_cisTarget_databases

[4]:

# Load DEM functions
from pycistarget.motif_enrichment_dem import *

[ ]:

# Preload db, you can also just provide the path to the db. Preloading the database is useful if you want to test different parameters.
db = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/dbs/human_brain.regions_vs_motifs.scores.feather'
dem_db = DEMDatabase(db, region_sets)
# Run (r23i27n24)
DEM_dict = DEM(dem_db = dem_db,
    region_sets = region_sets,
    specie = 'homo_sapiens',
    contrasts = 'Other',
    name = 'DEM',
    fraction_overlap = 0.4,
    max_bg_regions = 500,
    adjpval_thr = 0.05,
    log2fc_thr = 0.25,
    mean_fg_thr = 0,
    motif_hit_thr = None,
    cluster_buster_path = None,
    path_to_genome_fasta = None,
    path_to_motifs = None,
    annotation = ['Direct_annot', 'Motif_similarity_annot', 'Orthology_annot', 'Motif_similarity_and_Orthology_annot'],
    n_cpu = 1,
    tmp_dir = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/pycistarget/tmp')

[16]:

# Save
import pickle
with open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/topics/topic_DEM_dict.pkl', 'wb') as f:
  pickle.dump(DEM_dict, f)

We can load the results for exploration.

[ ]:

# Load
import pickle
infile = open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/topics/topic_DEM_dict.pkl', 'rb')
DEM_dict = pickle.load(infile)
infile.close()

To visualize motif enrichment results, we can use the DEM_results() function:

[9]:

DEM_dict.DEM_results('Topic8')

[9]:

	Contrast	Direct_annot	Motif_similarity_annot	Orthology_annot	Motif_similarity_and_Orthology_annot	Log2FC	Adjusted_pval	Mean_fg	Mean_bg	Motif_hit_thr	Motif_hits
jaspar__MA0380.1	Topic8	NaN	NaN	NaN	NaN	0.461394	0.0	886290.621233	643698.818	508052.0	4633.0
cisbp__M1832	Topic8	NaN	NaN	NaN	NaN	0.455054	0.0	816591.845921	595689.658	743376.0	3501.0
cisbp__M2204	Topic8	NaN	NaN	NaN	NaN	0.454949	0.0	787321.104779	574379.2	355010.0	5439.0
cisbp__M4269	Topic8	NaN	NaN	NaN	NaN	0.453209	0.0	873708.839743	638171.122	493375.0	4761.0
cisbp__M2229	Topic8	NaN	NaN	NaN	NaN	0.44815	0.0	878405.843147	643855.788	545897.0	4531.0
swissregulon__sacCer__CAT8	Topic8	NaN	NaN	NaN	NaN	0.443597	0.0	922601.99937	678388.372	302640.0	5494.0
swissregulon__sacCer__YER184C	Topic8	NaN	NaN	NaN	NaN	0.442054	0.0	872433.128861	642185.628	431083.0	4879.0
jaspar__MA0399.1	Topic8	NaN	NaN	NaN	NaN	0.441081	0.0	791910.863699	583307.812	364457.0	5380.0
jaspar__MA0424.1	Topic8	NaN	NaN	NaN	NaN	0.436862	0.0	876083.611777	647197.768	500738.0	4739.0
jaspar__MA0976.1	Topic8	NaN	HCFC1	NaN	NaN	0.426653	0.0	900716.205144	670120.232	390518.0	5140.0
scertf__badis.GSM1	Topic8	NaN	NaN	NaN	NaN	0.426364	0.0	842439.279032	626888.536	371765.0	5298.0
jaspar__MA0429.1	Topic8	NaN	NaN	NaN	NaN	0.425892	0.0	837182.488463	623180.586	635210.0	3857.0
yetfasco__YJL089W_573	Topic8	NaN	NaN	NaN	NaN	0.425206	0.0	884322.779221	658583.91	506342.0	4647.0
jaspar__MA0275.1	Topic8	NaN	NaN	NaN	NaN	0.423556	0.0	905976.427815	675482.118	634185.0	4472.0
transfac_pro__M01909	Topic8	NaN	NaN	NaN	NaN	0.422804	0.0	868256.471693	647696.394	438816.0	5169.0
transfac_pro__M01903	Topic8	NaN	NaN	NaN	NaN	0.416706	0.0	879336.868995	658740.264	411077.0	5275.0
yetfasco__YLL054C_526	Topic8	NaN	NaN	NaN	NaN	0.415834	0.0	841516.129114	630788.554	626761.0	3888.0
cisbp__M1670	Topic8	NaN	NaN	NaN	NaN	0.414021	0.0	862424.710881	647274.616	381950.0	5190.0
cisbp__M1817	Topic8	NaN	NaN	NaN	NaN	0.413156	0.0	844792.154079	634420.838	640182.0	3985.0
cisbp__M1833	Topic8	NaN	NaN	NaN	NaN	0.412792	0.0	882749.336275	663093.104	576060.0	4528.0
transfac_pro__M01944	Topic8	NaN	NaN	NaN	NaN	0.41125	0.0	842157.115496	633278.268	633435.0	3861.0
cisbp__M1789	Topic8	NaN	NaN	NaN	NaN	0.41115	0.0	930161.202497	699503.06	454939.0	5227.0
cisbp__M1741	Topic8	NaN	NaN	NaN	NaN	0.408692	0.0	830298.690833	625469.214	395576.0	5173.0
yetfasco__YPR008W_1425	Topic8	NaN	NaN	NaN	NaN	0.407626	0.0	853055.628924	643087.122	588162.0	4030.0
dbcorrdb__NR2C2__ENCSR000EVN_1__m1	Topic8	NR2C2	BCLAF1, ELF1, ELK4, GABPA, HCFC1, KDM5A, PHF8, POLR2A	NaN	NaN	0.406612	0.0	929326.843147	701077.476	628366.0	4608.0
scertf__badis.RSC30	Topic8	NaN	NaN	NaN	NaN	0.404739	0.0	865810.460976	654009.604	419188.0	5018.0
cisbp__M2185	Topic8	NaN	NaN	NaN	NaN	0.40271	0.0	886534.752112	670606.726	424492.0	5099.0
transfac_pro__M01958	Topic8	NaN	NaN	NaN	NaN	0.401324	0.0	883890.052074	669248.812	505829.0	4646.0
cisbp__M1725	Topic8	NaN	NaN	NaN	NaN	0.400463	0.0	836091.119783	633435.454	597583.0	4408.0
dbcorrdb__RAD21__ENCSR000EHX_1__m7	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP2, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	CREB1, CUX1, E2F1, E2F6, EGR1, ELF1, ELK4, GABPA, HCFC1, HIC1, IRF1, JUND, KAT2A, KLF16, KLF3, MAX, MYC, NFYB, PBX3, POLR3G, RCOR1, REST, SP1, SP3, SP4, TBX15, WRNIP1, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZFX, ZNF263	NaN	ZFY	0.398591	0.0	881809.499433	668939.752	317937.0	5289.0
transfac_pro__M01634	Topic8	NaN	NaN	NaN	NaN	0.397873	0.0	874196.347245	663494.416	503138.0	4737.0
cisbp__M0679	Topic8	NaN	NaN	NaN	E2F3	0.396529	0.0	827186.170092	628399.882	465862.0	4591.0
transfac_pro__M01677	Topic8	NaN	NaN	NaN	NaN	0.395605	0.0	790460.546715	600884.762	348011.0	5503.0
jaspar__MA0358.1	Topic8	NaN	NaN	NaN	NaN	0.395311	0.0	867834.544446	659836.778	427430.0	5226.0
hocomoco__SP3_HUMAN.H11MO.0.B	Topic8	BRF1, CTCF, HDAC2, IRF1, KLF3, MAZ, NFYA, PBX3, RBBP5, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, XRCC4	BRF2, CEBPB, CUX1, E2F6, EGR1, EGR2, EGR3, EGR4, ESRRA, EZH2, FOS, KLF1, KLF5, KLF6, KLF9, KLF12, KLF14, KLF15, KLF16, MXI1, NELFE, NFYB, PATZ1, POLR2A, RAD21, RCOR1, REST, SMARCA4, SP9, TBX15, VEZF1, WT1, ZBTB7B, ZMIZ1, ZNF148, ZNF274, ZNF467	NaN	KLF17, KLF18, SP5, SP6, SP7, SP8, ZBTB17	0.394742	0.0	791743.868491	602220.348	674069.0	3642.0
cisbp__M1764	Topic8	NaN	NaN	NaN	NaN	0.3919	0.0	819102.519354	624258.634	659116.0	4015.0
cisbp__M0676	Topic8	NaN	NaN	NaN	NaN	0.388397	0.0	822895.763208	628674.146	495575.0	4396.0
cisbp__M0029	Topic8	NaN	NaN	NaN	NaN	0.388221	0.0	903160.520994	690078.932	648066.0	4390.0
dbcorrdb__HCFC1__ENCSR000EFN_1__m1	Topic8	HCFC1	BRF1, CEBPB, CTCF, CTCFL, ESRRA, EZH2, HDAC2, MAX, MXI1, MYC, NELFE, POLR2A, POLR3G, RAD21, RBBP5, RXRA, SMARCA4, SREBF1, SREBF2, TAF1, TFAP2B, XRCC4, YY1, ZMIZ1, ZNF143, ZNF274	NaN	NaN	0.387616	0.0	902224.048796	689652.544	337889.0	5256.0
swissregulon__hs__HIC1.p2	Topic8	HIC1	BRF1, BRF2, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, XRCC4, ZBTB7A, ZMIZ1, ZNF274	NaN	NaN	0.387151	0.0	893625.261253	683299.738	376598.0	5143.0
yetfasco__YER184C_512	Topic8	NaN	NaN	NaN	NaN	0.386949	0.0	875920.549994	669855.902	493882.0	4775.0
scertf__badis.CAT8	Topic8	NaN	NaN	NaN	NaN	0.386827	0.0	877876.132896	671408.286	302335.0	5600.0
cisbp__M1760	Topic8	NaN	NaN	NaN	NaN	0.386203	0.0	932429.931913	713439.948	365594.0	5324.0
jaspar__MA0375.1	Topic8	NaN	NaN	NaN	NaN	0.386124	0.0	900551.82083	689086.822	343537.0	5330.0
transfac_pro__M01899	Topic8	NaN	NaN	NaN	NaN	0.385766	0.0	894582.876686	684689.004	399441.0	5151.0
transfac_pro__M03190	Topic8	NaN	NaN	NaN	NaN	0.384063	0.0	900199.747825	689801.9	506826.0	4677.0
scertf__zhao.RDS2	Topic8	NaN	NaN	NaN	NaN	0.383828	0.0	818441.655781	627254.632	341307.0	5780.0
cisbp__M1350	Topic8	NaN	NaN	NaN	NaN	0.382772	0.0	804969.322154	617381.37	623666.0	4089.0
scertf__badis.YER184C	Topic8	NaN	NaN	NaN	NaN	0.381382	0.0	843631.769008	647657.708	385536.0	5425.0
cisbp__M4310	Topic8	NaN	NaN	NaN	NaN	0.380435	0.0	921342.445972	707780.806	383055.0	5193.0
transfac_pro__M03214	Topic8	NaN	NaN	NaN	NaN	0.379133	0.0	921190.353045	708302.822	335150.0	5463.0
transfac_pro__M01908	Topic8	NaN	NaN	NaN	NaN	0.378754	0.0	916816.683268	705125.178	382149.0	5194.0
transfac_pro__M01219	Topic8	SP3	CEBPB, FOS, NFYB, PBX3, SP2, SP4, ZBTB7B	SP1	NaN	0.378326	0.0	805275.151683	619522.298	476012.0	4861.0
yetfasco__YLR278C_2112	Topic8	NaN	NaN	NaN	NaN	0.378021	0.0	859261.936452	661195.566	435338.0	5200.0
cisbp__M1711	Topic8	NaN	NaN	NaN	NaN	0.376997	0.0	843288.311814	649364.826	704364.0	3802.0
cisbp__M6482	Topic8	BRF1, CTCF, HDAC2, IRF1, KLF3, MAZ, NFYA, PBX3, RBBP5, SP1, SP2, SP3, SP4, SREBF2, SUPT20H, XRCC4	BRF2, CEBPB, CUX1, E2F6, EGR1, EGR2, EGR3, EGR4, ESRRA, EZH2, FOS, KLF1, KLF12, KLF14, KLF15, KLF16, KLF5, KLF6, KLF9, MXI1, NELFE, NFYB, PATZ1, POLR2A, RAD21, RCOR1, REST, SMARCA4, SP9, SREBF1, TBX15, VEZF1, WT1, ZBTB7B, ZNF148, ZNF274, ZNF467	NaN	KLF17, KLF18, SP5, SP6, SP7, SP8, ZBTB17	0.376711	0.0	785904.248771	605296.806	675431.0	3639.0
jaspar__MA1004.1	Topic8	NaN	NaN	NaN	NaN	0.375806	0.0	875147.144244	674453.698	413546.0	4925.0
cisbp__M1797	Topic8	NaN	NaN	NaN	NaN	0.375479	0.0	866262.148783	667757.798	749808.0	3824.0
scertf__harbison.SUT1	Topic8	NaN	BRF1, ESRRA, EZH2, MXI1, POLR2A, SMARCA4, SREBF1, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.374773	0.0	782557.664733	603529.392	108604.0	6987.0
cisbp__M1756	Topic8	NaN	NaN	NaN	NaN	0.37357	0.0	808669.455428	624187.908	517089.0	4739.0
swissregulon__sacCer__RSC30	Topic8	NaN	NaN	NaN	NaN	0.373132	0.0	950196.844534	733651.322	220893.0	6097.0
cisbp__M1755	Topic8	NaN	NaN	NaN	NaN	0.372625	0.0	836735.307906	646274.112	584563.0	4525.0
cisbp__M1705	Topic8	NaN	NaN	NaN	NaN	0.372383	0.0	818756.600681	632493.992	799408.0	3229.0
cisbp__M1729	Topic8	NaN	NaN	NaN	NaN	0.372347	0.0	811683.529063	627045.696	719848.0	3612.0
cisbp__M2234	Topic8	NaN	NaN	NaN	NaN	0.371661	0.0	837674.04287	647431.68	627047.0	3890.0
transfac_pro__M01620	Topic8	NaN	NaN	NaN	NaN	0.371542	0.0	906135.097844	700402.61	534803.0	4653.0
cisbp__M1774	Topic8	NaN	NaN	NaN	NaN	0.371078	0.0	865051.863825	668861.814	233559.0	6089.0
dbcorrdb__ZBTB7A__ENCSR000BQA_1__m1	Topic8	ZBTB7A	BRF1, BRF2, MXI1, RAD21, SMARCA4, SREBF1	NaN	NaN	0.368422	0.0	921395.080318	713739.846	712845.0	4269.0
cisbp__M1796	Topic8	NaN	NaN	NaN	NaN	0.368206	0.0	845107.451645	654742.948	636436.0	4274.0
yetfasco__YDL170W_651	Topic8	NaN	NaN	NaN	NaN	0.367904	0.0	903306.609003	699979.076	386236.0	5222.0
dbcorrdb__SUPT20H__ENCSR000ECQ_1__m5	Topic8	BRF1, BRF2, CEBPB, CTCF, CUX1, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP3, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	E2F6, EGR1, EGR4, ETS1, GABPA, IRF1, KAT2A, KLF15, KLF16, KLF3, MAX, MYC, PATZ1, PBX3, POLR3G, RREB1, SP1, SP2, TBX15, TRIM28, VEZF1, WT1, ZBTB7B, ZEB1, ZNF263, ZNF341, ZNF460, ZNF467	NaN	SP5, ZBTB17, ZNF16, ZNF189, ZNF23, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.36779	0.0	806953.284579	625363.698	621088.0	3794.0
dbcorrdb__PHF8__ENCSR000AQH_1__m2	Topic8	PHF8, TAF1, YY1	KDM5A, MXI1, MYC, POLR2A, TAF7, THAP1, ZMIZ1, ZNF91	NaN	NaN	0.367399	0.0	949216.482033	735812.314	266706.0	5874.0
cisbp__M1772	Topic8	NaN	NaN	NaN	NaN	0.366804	0.0	901188.566259	698870.482	538041.0	4960.0
cisbp__M0004	Topic8	NaN	TAF1	NaN	NaN	0.366309	0.0	843896.67419	654665.1	246065.0	6090.0
cisbp__M1722	Topic8	NaN	NaN	NaN	NaN	0.366192	0.0	828458.405624	642740.954	541456.0	4771.0
transfac_pro__M03807	Topic8	SP1, SP2, SP3, SP4	BRF1, BRF2, CTCF, EGR1, ESRRA, EZH2, FOS, HDAC2, IRF1, KLF13, KLF14, KLF15, KLF16, KLF3, KLF5, KLF9, MAZ, MXI1, NFYA, NFYB, PBX3, RAD21, RBBP5, SMARCA4, SP8, SP9, SREBF1, SREBF2, SUPT20H, WT1, XRCC4, ZNF148	NaN	KLF17, KLF18, SP5, SP6, SP7	0.365537	0.0	800126.513554	621042.22	526118.0	4384.0
flyfactorsurvey__Bteb2_SANGER_2.5_FBgn0025679	Topic8	NaN	KLF16	KLF15	SP4	0.36536	0.0	813937.351784	631839.384	481330.0	4868.0
transfac_pro__M03193	Topic8	NaN	NaN	NaN	NaN	0.365106	0.0	906863.560459	704099.728	414943.0	5027.0
dbcorrdb__ZNF143__ENCSR000DZL_1__m3	Topic8	ZNF143	BHLHE40, BRF1, E2F6, ETS1, EZH2, HCFC1, MAX, MXI1, MYC, PHF8, POLR2A, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.364743	0.0	903975.754003	702033.92	552749.0	4707.0
dbcorrdb__CEBPB__ENCSR000EBV_1__m2	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, TRIM28, XRCC4, ZMIZ1, ZNF274	CREB1, CUX1, E2F1, E2F6, EGR1, GABPA, HCFC1, KLF16, MAX, MYC, RCOR1, REST, SP1, SP2, SP3, SP4, TBX15, WT1, ZBTB7B, ZC3H11A, ZNF143, ZNF460	NaN	ZNF16, ZNF189, ZNF23, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.364609	0.0	895797.656916	695747.648	318850.0	5329.0
cisbp__M1811	Topic8	NaN	NaN	NaN	NaN	0.364478	0.0	834313.620855	648052.996	533444.0	4664.0
jaspar__MA1051.1	Topic8	NaN	HCFC1	NaN	NaN	0.364073	0.0	855930.448241	665030.486	381399.0	5256.0
swissregulon__sacCer__UGA3	Topic8	NaN	NaN	NaN	NaN	0.362308	0.0	880091.834951	684640.22	369686.0	5344.0
cisbp__M1830	Topic8	NaN	NaN	NaN	NaN	0.361639	0.0	833820.271719	648945.61	632054.0	4198.0
cisbp__M0020	Topic8	NaN	NaN	NaN	NaN	0.361375	0.0	853751.940865	664579.52	505725.0	4613.0
taipale_cyt_meth__KLF2_NRCCACRCCCN_eDBD_meth	Topic8	KLF13, KLF2, KLF4	KLF10, KLF1, KLF11, KLF12, KLF14, KLF15, KLF16, KLF17, KLF3, KLF5, KLF6, KLF7, KLF8, KLF9, SP1, SP2, SP3, SP4, SP8, SP9	NaN	KLF18, SP6, SP7	0.361367	0.0	841664.185096	655173.712	672431.0	3792.0
flyfactorsurvey__btd_NAR_FBgn0000233	Topic8	NaN	NaN	SP1, SP2, SP3, SP4	NaN	0.359558	0.0	817379.583407	637068.31	305036.0	5860.0
cisbp__M1762	Topic8	NaN	NaN	NaN	NaN	0.35952	0.0	810573.670659	631780.382	629929.0	4152.0
cisbp__M0018	Topic8	NaN	ATF3, KDM5A, PHF8, TAF1, YY1	NaN	NaN	0.358097	0.0	819160.149414	639102.838	355910.0	5599.0
cisbp__M1781	Topic8	NaN	NaN	NaN	NaN	0.357884	0.0	929194.576094	725058.028	302704.0	5625.0
elemento__GCCCCGCCC	Topic8	NaN	FOS, IRF1, KLF1, KLF12, KLF3, KLF4, KLF5, KLF6, MAZ, NFYB, PBX3, SP1, SP2, SP3, SP4, STAT1	NaN	SP6, SP7, SP8, SP9	0.357829	0.0	831514.737864	648862.644	564765.0	4108.0
dbcorrdb__SREBF1__ENCSR000DYU_1__m4	Topic8	SREBF1	BRF1, BRF2, EGR1, HDAC2, MAZ, NELFE, RBBP5, SMARCA4, SREBF2, SUPT20H, XRCC4	NaN	SP5	0.357213	0.0	823532.402976	642907.984	701044.0	3577.0
transfac_pro__M07617	Topic8	SP4	BRF1, CEBPB, CTCF, EGR1, ESRRA, EZH2, HDAC2, MXI1, NELFE, PBX3, POLR2A, RAD21, RBBP5, SMARCA4, SP1, SP2, SP3, SREBF1, SREBF2, TEAD2, WT1, XRCC4, ZNF148, ZNF281	NaN	NaN	0.356364	0.0	792186.433237	618801.194	589516.0	4087.0
c2h2_zfs__M0522	Topic8	NaN	NaN	NaN	NaN	0.356349	0.0	852692.21561	666070.858	601484.0	4425.0
elemento__CCCGGCC	Topic8	NaN	NaN	NaN	NaN	0.355453	0.0	815440.924095	637368.156	564677.0	4248.0
dbcorrdb__POLR2A__ENCSR000BQB_1__m2	Topic8	POLR2A	TAF1, YY1, YY2, ZNF597	NaN	NaN	0.354303	0.0	913191.328584	714341.42	354190.0	5353.0
transfac_pro__M01253	Topic8	CNOT3	EZH2, MXI1, ZMIZ1	NaN	NaN	0.353961	0.0	873163.182449	683191.524	364404.0	5269.0
cisbp__M1753	Topic8	NaN	NaN	NaN	NaN	0.353646	0.0	839515.116757	657007.784	664131.0	4046.0
transfac_pro__M03208	Topic8	NaN	NaN	NaN	NaN	0.353609	0.0	921862.867608	721472.01	429856.0	5194.0
jaspar__MA0392.1	Topic8	NaN	NaN	NaN	NaN	0.353332	0.0	910109.816164	712410.536	534504.0	4653.0
cisbp__M0675	Topic8	NaN	NaN	NaN	NaN	0.352796	0.0	829630.53915	649654.534	558881.0	4114.0
cisbp__M4783	Topic8	NaN	KLF16	KLF15	SP4	0.350954	0.0	910509.20754	713898.87	397872.0	5153.0
cisbp__M0677	Topic8	NaN	NaN	NaN	E2F2, E2F3	0.349352	0.0	875360.299962	687102.258	446865.0	4957.0
transfac_pro__M03567	Topic8	SP1, SP2	CTCF, EGR1, EZH2, FOS, IRF1, KLF13, KLF14, KLF15, KLF16, KLF3, KLF5, KLF9, MAZ, NFYA, NFYB, PATZ1, PBX3, SP3, SP4, SP8, SP9	NaN	KLF17, KLF18, SP6, SP7	0.349129	0.0	791136.903669	621088.258	679349.0	3680.0
jaspar__MA1034.1	Topic8	NaN	NaN	NaN	NaN	0.347967	0.0	981224.918169	770938.834	190609.0	6345.0
swissregulon__hs__TFDP1.p2	Topic8	TFDP1	NaN	NaN	NaN	0.34786	0.0	914616.974278	718659.03	242781.0	5818.0
cisbp__M1714	Topic8	NaN	NaN	NaN	NaN	0.347644	0.0	856703.191149	673254.092	726046.0	3784.0
cisbp__M4237	Topic8	NaN	NaN	NaN	NaN	0.347577	0.0	872440.340436	685653.27	370789.0	5137.0
cisbp__M1732	Topic8	NaN	NaN	NaN	NaN	0.34686	0.0	822780.58555	646947.3	800653.0	3342.0
transfac_pro__M01963	Topic8	NaN	NaN	NaN	NaN	0.346415	0.0	863413.734964	679106.206	312822.0	5660.0
cisbp__M0011	Topic8	NaN	TAF1	NaN	NaN	0.346278	0.0	889009.560081	699304.574	587359.0	4499.0
elemento__CGCGCCG	Topic8	NaN	NaN	NaN	NaN	0.346107	0.0	931359.492876	732704.55	200952.0	6353.0
cisbp__M2097	Topic8	NaN	NaN	NaN	NaN	0.345947	0.0	891036.757786	701059.894	640775.0	4442.0
cisbp__M1707	Topic8	NaN	NaN	NaN	NaN	0.345889	0.0	845583.203253	665324.472	770142.0	3506.0
cisbp__M0043	Topic8	NaN	NaN	NaN	NaN	0.345637	0.0	970333.67129	763614.24	358050.0	5849.0
jaspar__MA0975.1	Topic8	NaN	NaN	NaN	NaN	0.345581	0.0	935296.922204	736070.016	243742.0	5914.0
swissregulon__sacCer__ARO80	Topic8	NaN	NaN	NaN	NaN	0.345495	0.0	915044.948682	720175.2	394025.0	5624.0
cisbp__M1810	Topic8	NaN	NaN	NaN	NaN	0.345437	0.0	868301.653007	683413.572	629040.0	4414.0
transfac_pro__M01057	Topic8	NaN	HCFC1	NaN	NaN	0.345293	0.0	814206.653385	640901.122	148082.0	6709.0
transfac_pro__M01639	Topic8	NaN	NaN	NaN	NaN	0.345136	0.0	888255.927878	699265.24	614957.0	4547.0
transfac_pro__M07354	Topic8	EGR1	EGR2, EGR3, EGR4, WT1	NaN	NaN	0.344685	0.0	816847.68516	643251.23	478599.0	4747.0
cisbp__M1792	Topic8	NaN	NaN	NaN	NaN	0.344214	0.0	832543.904678	655825.834	640563.0	4331.0
dbcorrdb__JUND__ENCSR000DYS_1__m2	Topic8	JUND	BRF1, ESRRA, EZH2, MXI1, NELFE, POLR2A, RAD21, SMARCA4, SREBF1, SREBF2, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.343627	0.0	847968.862312	668248.432	266086.0	5980.0
transfac_pro__M03170	Topic8	NaN	NaN	NaN	NaN	0.343081	0.0	935770.022317	737719.826	270642.0	5883.0
dbcorrdb__POLR2A__ENCSR000EEM_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.342515	0.0	923299.110453	728174.162	489468.0	4897.0
taipale_cyt_meth__SP8_NCCACGCCCMYN_eDBD	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF12, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP2, SP4	KLF17, KLF18	KLF3, KLF7, KLF8, SP6, SP7	0.342457	0.0	861581.738621	679526.848	696527.0	3793.0
yetfasco__YDL170W_486	Topic8	NaN	NaN	NaN	NaN	0.341763	0.0	872152.928382	688195.338	355449.0	5478.0
dbcorrdb__SP1__ENCSR000BKO_1__m2	Topic8	SP1	EGR1, IRF1, KLF3, KLF5, KLF6, MAZ, NFYA, NFYB, PBX3, SP2, SP3, SP4	NaN	SP6, SP7, SP8, SP9	0.341287	0.0	875959.026226	691426.946	457383.0	4772.0
taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	Topic8	E2F2	NaN	NaN	NaN	0.341009	0.0	858022.828647	677399.642	810295.0	3597.0
transfac_pro__M05125	Topic8	NaN	NaN	NaN	NaN	0.340824	0.0	845875.353171	667895.076	265992.0	5946.0
jaspar__MA0280.1	Topic8	NaN	NaN	NaN	NaN	0.340819	0.0	921328.223805	727474.252	299413.0	5521.0
dbcorrdb__POLR2A__ENCSR000DYO_1__m1	Topic8	POLR2A	GABPA, MXI1	NaN	NaN	0.340817	0.0	942109.046148	743883.548	293342.0	5718.0
scertf__badis.NHP10	Topic8	NaN	NaN	NaN	NaN	0.340735	0.0	829498.45568	655004.388	973988.0	2638.0
jaspar__MA0361.1	Topic8	NaN	NaN	NaN	NaN	0.340627	0.0	865679.278275	683625.434	315024.0	5647.0
cisbp__M1804	Topic8	NaN	NaN	NaN	NaN	0.340405	0.0	830624.558568	656043.34	698992.0	3929.0
cisbp__M1820	Topic8	NaN	NaN	NaN	NaN	0.340368	0.0	827614.044635	653682.348	731129.0	3657.0
dbcorrdb__MAZ__ENCSR000ECL_1__m1	Topic8	MAZ, SP2	BRF1, BRF2, CEBPB, CTCF, E2F6, EGR1, EZH2, FOS, HDAC2, IRF1, KLF1, KLF3, KLF5, KLF6, MXI1, MYC, NELFE, NFYA, NFYB, PBX3, PGAM2, POLR2A, RAD21, RBBP5, SMARCA4, SP1, SP3, SP4, SREBF1, SREBF2, STAT1, SUPT20H, TAF1, UBTF, XRCC4, ZBTB7B, ZMIZ1, ZNF274	NaN	NaN	0.339971	0.0	881953.859665	696794.21	348428.0	5282.0
factorbook__UA3	Topic8	ZBTB7A	BRF2, EZH2, FOS, MXI1, POLR2A, RAD21, SP1, SP2	NaN	NaN	0.339521	0.0	858005.17274	678084.722	383450.0	5431.0
hocomoco__SP2_HUMAN.H11MO.0.A	Topic8	BRF1, CTCF, EGR1, ESRRA, HDAC2, IRF1, KLF3, MAZ, NFYA, NFYB, PBX3, RAD21, RBBP5, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, XRCC4	BRF2, CEBPB, CUX1, E2F6, EGR2, EGR3, EGR4, ELF1, EZH2, FOS, KLF1, KLF5, KLF6, KLF9, KLF15, KLF16, MAX, MXI1, MYC, NELFE, PATZ1, PHF8, POLR2A, RCOR1, REST, STAT1, SUPT20H, TBX15, VEZF1, WT1, ZBTB7A, ZBTB7B, ZMIZ1, ZNF274, ZNF467	NaN	KLF17, KLF18, SP5, SP6, SP7, SP8, SP9, ZBTB17	0.339472	0.0	810794.632581	640795.6	418380.0	4876.0
transfac_public__M00189	Topic8	TFAP2A, TFAP2B, TFAP2C	NaN	NaN	NaN	0.339312	0.0	802417.819191	634245.63	795340.0	3464.0
cisbp__M2153	Topic8	NaN	NaN	NaN	NaN	0.33876	0.0	919765.538646	727277.56	716283.0	4172.0
transfac_pro__M02036	Topic8	WT1	EGR1	NaN	NaN	0.338246	0.0	799817.172488	632657.458	702476.0	3688.0
cisbp__M0044	Topic8	NaN	NaN	NaN	NaN	0.338234	0.0	820943.271971	649373.684	669073.0	3777.0
cisbp__M1749	Topic8	NaN	NaN	NaN	NaN	0.338096	0.0	844176.148783	667814.818	788752.0	3415.0
cisbp__M0033	Topic8	NaN	HCFC1	NaN	NaN	0.338018	0.0	875003.343967	692239.352	364594.0	5288.0
cisbp__M4536	Topic8	E2F1	NaN	NaN	NaN	0.337998	0.0	855266.892952	676634.53	581370.0	4152.0
dbcorrdb__WRNIP1__ENCSR000EAA_1__m3	Topic8	WRNIP1	BRF1, BRF2, ESRRA, EZH2, MXI1, RAD21	NaN	NaN	0.337763	0.0	863771.53045	683474.148	423979.0	4791.0
transfac_pro__M01273	Topic8	SP4	CTCF, EGR1, ESRRA, EZH2, FOS, IRF1, KLF12, KLF15, KLF16, KLF5, MXI1, NFYB, PBX3, POLR2A, SMARCA4, SP1, SP2, SP3, WT1	NaN	NaN	0.337118	0.0	784138.920565	620740.844	622464.0	3962.0
cisbp__M2215	Topic8	NaN	NaN	NaN	NaN	0.336971	0.0	871943.499054	690319.362	349903.0	5498.0
cisbp__M1740	Topic8	NaN	NaN	NaN	NaN	0.336954	0.0	827022.904552	654763.162	540868.0	4813.0
cisbp__M0674	Topic8	NaN	E2F1, E2F3, E2F4, TFDP1	NaN	NaN	0.336782	0.0	827683.771782	655364.458	487023.0	4458.0
cisbp__M1798	Topic8	NaN	NaN	NaN	NaN	0.336655	0.0	833464.68579	659999.94	675289.0	3991.0
dbcorrdb__POLR2A__ENCSR000DMZ_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.3365	0.0	948386.455428	751084.232	276372.0	5872.0
predrem__nrMotif583	Topic8	NaN	NaN	NaN	NaN	0.336354	0.0	978382.626277	774918.656	134793.0	6692.0
transfac_pro__M02089	Topic8	E2F3	NaN	NaN	NaN	0.3363	0.0	797526.039213	631696.494	414696.0	5372.0
dbcorrdb__ZBTB7A__ENCSR000BME_1__m1	Topic8	ZBTB7A	BRF1, BRF2, CTCF, ESRRA, EZH2, HDAC2, HIC1, MAX, MXI1, MYC, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP4, SREBF1, SREBF2, XRCC4, ZMIZ1	NaN	NaN	0.336158	0.0	945573.475224	749034.24	317622.0	5657.0
dbcorrdb__RBBP5__ENCSR000AQI_1__m2	Topic8	RBBP5	NaN	NaN	NaN	0.33607	0.0	934137.113227	740019.948	366814.0	5449.0
cisbp__M1770	Topic8	NaN	NaN	NaN	NaN	0.33588	0.0	828166.787795	656156.992	582169.0	4546.0
cisbp__M1815	Topic8	NaN	NaN	NaN	NaN	0.335626	0.0	902982.196318	715559.358	332103.0	5905.0
dbcorrdb__POLR2A__ENCSR000BHI_1__m1	Topic8	NRF1, POLR2A	BRF1, E2F1, EZH2, MXI1, MYC, ZNF143	NaN	NaN	0.335614	0.0	948281.222923	751462.602	213753.0	6053.0
transfac_pro__M01684	Topic8	NaN	NaN	NaN	NaN	0.335538	0.0	894125.255327	708584.016	473387.0	5010.0
transfac_pro__M00803	Topic8	E2F1, E2F3, E2F4, TFDP1	NaN	NaN	NaN	0.335276	0.0	804636.009204	637780.516	429520.0	4980.0
dbcorrdb__POLR2A__ENCSR000EFB_1__m3	Topic8	POLR2A	NaN	NaN	NaN	0.334923	0.0	922417.477115	731316.768	351129.0	5430.0
dbcorrdb__POLR2A__ENCSR000BKI_1__m1	Topic8	HCFC1, POLR2A, SIN3A	BCLAF1, E2F6, ELF1, ELK1, ELK4, ETS1, EZH2, FOXP2, GABPA, MXI1, PHF8, PML, RBBP5, TAF1, THAP1, ZNF143	NaN	NaN	0.334325	0.0	937270.79246	743401.136	244692.0	5896.0
cisbp__M1780	Topic8	NaN	NaN	NaN	NaN	0.334053	0.0	828329.805447	657118.116	526644.0	4643.0
elemento__CCCGGCG	Topic8	NaN	NaN	NaN	NaN	0.334026	0.0	864597.354684	685901.77	338345.0	5519.0
hocomoco__SP1_MOUSE.H11MO.1.A	Topic8	SP2, SP3, SP4	CTCF, EGR1, EZH2, FOS, IRF1, KLF5, KLF9, KLF12, KLF15, KLF16, NFYA, NFYB, PBX3, STAT1, TEAD2, WT1, ZNF281	SP1	SP6, SP7, SP8, SP9, ZBTB17	0.333745	0.0	798162.392763	633321.056	587139.0	4179.0
dbcorrdb__EZH2__ENCSR000ASW_1__m1	Topic8	EZH2	MXI1, MYC, RAD21	NaN	NaN	0.333738	0.0	868612.290253	689224.86	459904.0	4781.0
dbcorrdb__SIN3A__ENCSR000DYX_1__m1	Topic8	E2F4, E2F6, SIN3A	NaN	NaN	NaN	0.33327	0.0	936474.244358	743312.534	504011.0	5013.0
transfac_pro__M09562	Topic8	NaN	ATF3, TAF1	NaN	NaN	0.332835	0.0	807282.427311	640961.868	454238.0	4989.0
dbcorrdb__TAF1__ENCSR000BJN_1__m1	Topic8	KDM5A, RBBP5, TAF1, TAF7, YY1	ATF3, BCLAF1, BRF1, CTCF, ELF1, ELK1, ETS1, EZH2, GABPA, HCFC1, KDM5B, MAX, MAZ, MXI1, MYC, PHF8, POLR2A, RFX1, SAP30, SIN3A, SMARCA4, SREBF1, SREBF2, XRCC4, ZMIZ1, ZNF274	NaN	TAF1L	0.332617	0.0	941108.442693	747329.492	364414.0	5589.0
swissregulon__hs__PATZ1.p2	Topic8	PATZ1	SP1, SP2, SP3, SP4	NaN	ZBTB17	0.332511	0.0	868810.430841	689968.644	417633.0	5076.0
jaspar__MA0410.1	Topic8	NaN	NaN	NaN	NaN	0.332416	0.0	876751.696255	696320.928	353116.0	5482.0
hocomoco__KLF3_HUMAN.H11MO.0.B	Topic8	KLF1, KLF3, PBX3, SP1, SP2, SP3	BRF1, BRF2, CTCF, CUX1, EGR1, EGR2, EGR3, EGR4, ESRRA, EZH2, FOS, HDAC2, IRF1, KLF4, KLF5, KLF6, KLF9, KLF12, KLF15, MAZ, NFYA, NFYB, RAD21, RBBP5, RCOR1, SMARCA4, SP4, SREBF1, SREBF2, SUPT20H, WT1, XRCC4, ZBTB7B	NaN	KLF7, KLF8, KLF17, KLF18, SP6, SP7, SP8, SP9	0.331936	0.0	829075.852604	658675.468	571552.0	4162.0
taipale_cyt_meth__KLF6_NRCCACGCCCN_eDBD	Topic8	KLF2, KLF4, KLF6	KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF3, KLF5, KLF9, SP1, SP3, SP8, SP9	KLF7	KLF10, KLF17, KLF18, KLF8, SP6, SP7	0.331539	0.0	875511.833817	695759.062	493186.0	4917.0
hocomoco__SP2_HUMAN.H11MO.1.B	Topic8	FOS, NFYA, NFYB, PBX3, SP1, SP2, SP4	IRF1, KLF3, KLF5, KLF9, KLF12, KLF15, SP3, SP8, SP9, STAT1	NaN	E2F4, KLF17, KLF18, SP6, SP7	0.331447	0.0	826046.833186	656491.468	667173.0	3904.0
cisbp__M2088	Topic8	NaN	NaN	NaN	NaN	0.331039	0.0	857359.008196	681569.326	789012.0	3562.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIL_1__m1	Topic8	NaN	POLR2A	NaN	NaN	0.330732	0.0	930874.293658	740168.616	389775.0	5329.0
dbcorrdb__MAZ__ENCSR000DZA_1__m1	Topic8	MAZ	BRF1, BRF2, CEBPB, CTCF, EGR1, ESRRA, EZH2, HDAC2, KLF16, KLF3, KLF6, MXI1, MYC, NELFE, POLR2A, RAD21, RBBP5, RCOR1, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.330442	0.0	868301.265036	690553.788	461029.0	4653.0
cisbp__M1906	Topic8	SP1, SP2, SP4	EGR1, FOS, IRF1, KLF12, KLF15, KLF16, KLF3, KLF5, KLF6, MAZ, NFYA, NFYB, PATZ1, PBX3, SP3, STAT1, TEAD2, WT1, ZNF281	NaN	E2F4, SP6, SP7, SP8, SP9, ZBTB17	0.330247	0.0	827435.466146	658142.54	585248.0	4341.0
cisbp__M1715	Topic8	NaN	NaN	NaN	NaN	0.329603	0.0	840595.826756	668908.916	962268.0	2782.0
transfac_pro__M01934	Topic8	NaN	NaN	NaN	NaN	0.329456	0.0	919450.621233	731732.398	165096.0	6463.0
dbcorrdb__EZH2__ENCSR000ASW_1__m3	Topic8	EZH2	NaN	NaN	NaN	0.329234	0.0	855926.604463	681282.34	459155.0	4672.0
dbcorrdb__POLR2A__ENCSR000DMK_1__m1	Topic8	ELK1, GABPA, POLR2A	CREB1, CTCF, ELF1, ELK4, ESRRA, ETS1, EZH2, MXI1, MYC, PML, SIN3A, SMARCA4, SREBF1, SRF, TAF1, XRCC4, ZNF143	NaN	NaN	0.328528	0.0	940863.67999	749255.312	340034.0	5557.0
c2h2_zfs__M3835	Topic8	ZBTB7A	BRF2, EZH2, FOS, IRF1, MXI1, NFYB, POLR2A, RAD21, SP1, SP2	NaN	NaN	0.328503	0.0	823067.824612	655460.108	398244.0	5384.0
taipale_cyt_meth__KLF4_NRCCMCGCCCN_eDBD_meth	Topic8	KLF2, KLF4	KLF11, KLF13, KLF14, KLF16, KLF5, KLF6, SP1, SP3	KLF8	KLF12, KLF3, KLF7, SP6, SP7, SP8, SP9	0.328396	0.0	830472.473963	661406.276	860162.0	3057.0
cisbp__M1750	Topic8	NaN	NaN	NaN	NaN	0.327318	0.0	843687.615181	672433.324	739235.0	3770.0
cisbp__M0401	Topic8	NaN	EGR1, EGR2, EGR3, EGR4, KLF15, SP1, SP2, TEAD2	SP4	SP3, SP6, SP7, SP8, SP9, WT1	0.326951	0.0	886337.385702	706605.544	121641.0	6926.0
elemento__CCGCCCG	Topic8	NaN	NaN	NaN	NaN	0.326884	0.0	873323.246123	696262.826	256753.0	5849.0
dbcorrdb__YY1__ENCSR000EWF_1__m2	Topic8	YY1	ELK1, GABPA, POLR2A	NaN	NaN	0.326864	0.0	937481.666246	747423.53	368559.0	5389.0
cisbp__M0668	Topic8	E2F2	E2F1, E2F3, E2F4	NaN	E2F6	0.32686	0.0	867735.857773	691819.762	555568.0	4354.0
yetfasco__YDR207C_2239	Topic8	NaN	NaN	NaN	NaN	0.326519	0.0	822256.102761	655714.756	583399.0	4238.0
dbcorrdb__NELFE__ENCSR000DOF_1__m2	Topic8	NELFE	NaN	NaN	NaN	0.326434	0.0	829339.056361	661402.364	661966.0	3766.0
dbcorrdb__PBX3__ENCSR000BGR_1__m3	Topic8	FOS, IRF1, KLF3, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	BRF1, BRF2, CTCF, CUX1, EGR1, EGR2, EGR3, EGR4, ESRRA, HDAC2, KLF1, KLF12, KLF14, KLF15, KLF5, KLF6, KLF9, MAZ, NELFE, PATZ1, RAD21, RBBP5, RCOR1, REST, SMARCA4, SREBF1, SREBF2, STAT1, SUPT20H, TBX15, WT1, XRCC4, ZBTB7B	NaN	E2F4, KLF17, KLF18, SP5, SP6, SP7, SP8, SP9	0.3262	0.0	853330.150675	680645.79	557183.0	4316.0
cisbp__M1994	Topic8	NaN	NaN	DEAF1	NaN	0.325994	0.0	939620.073509	749580.746	492444.0	4915.0
transfac_pro__M00931	Topic8	SP1, SP2, SP3, SP4	FOS, IRF1, KLF1, KLF12, KLF15, KLF3, KLF4, KLF5, KLF6, NFYA, NFYB, PBX3, STAT1	NaN	SP6, SP7, SP8, SP9	0.325889	0.0	780727.956878	622869.904	413733.0	5131.0
dbcorrdb__EZH2__ENCSR000ASZ_1__m1	Topic8	EZH2	NaN	NaN	NaN	0.325764	0.0	859869.351658	686068.706	639834.0	3980.0
cisbp__M1783	Topic8	NaN	NaN	NaN	NaN	0.325634	0.0	842785.596268	672498.924	857427.0	3077.0
transfac_pro__M01685	Topic8	NaN	NaN	NaN	NaN	0.32452	0.0	811096.334888	647712.448	409387.0	5385.0
transfac_pro__M01898	Topic8	NaN	NaN	NaN	NaN	0.324322	0.0	877784.585172	701063.408	375287.0	5119.0
cisbp__M1744	Topic8	NaN	NaN	NaN	NaN	0.324297	0.0	903822.711638	721871.708	460263.0	4965.0
cisbp__M5853	Topic8	KLF13, KLF14, KLF15, SP1, SP8, SP9	CPSF4, FOS, IRF1, KLF10, KLF1, KLF11, KLF12, KLF16, KLF17, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, NFYB, PBX3, SP2, SP3, SP4, STAT1, TEAD2, WT1	NaN	EGR1, EGR2, EGR3, EGR4, KLF18, SP6, SP7	0.324279	0.0	828441.356197	661674.13	945943.0	2806.0
transfac_public__M00196	Topic8	PBX3, SP1, SP2, SP3, SP4	CTCF, EZH2, FOS, IRF1, KLF12, KLF13, KLF14, KLF15, KLF16, KLF2, KLF3, KLF5, KLF9, MAZ, NFYA, NFYB, SP8, SP9, STAT1	NaN	KLF17, KLF18, SP6, SP7	0.32419	0.0	787384.652377	628921.03	512362.0	4505.0
dbcorrdb__POLR2A__ENCSR000FAJ_1__m1	Topic8	POLR2A	PHF8, TAF1, THAP1	NaN	NaN	0.324091	0.0	924255.72349	738296.658	462515.0	5076.0
transfac_pro__M03893	Topic8	WT1	CTCF, EGR1, EGR2, ESRRA, HDAC2, NELFE, PATZ1, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, TEAD2, XRCC4	NaN	EGR3, EGR4	0.323931	0.0	795149.310554	635236.826	470778.0	4715.0
hocomoco__SP1_HUMAN.H11MO.1.A	Topic8	SP1, SP2, SP3, SP4	BRF1, BRF2, CTCF, EGR1, ESRRA, EZH2, FOS, IRF1, KLF3, KLF5, KLF6, KLF9, KLF12, KLF14, KLF15, KLF16, MAZ, NELFE, NFYA, NFYB, PATZ1, PBX3, POLR2A, SMARCA4, SP9, STAT1	NaN	KLF17, KLF18, SP6, SP7, SP8	0.32372	0.0	831929.416341	664717.506	459044.0	4709.0
predrem__nrMotif2090	Topic8	BRF1, BRF2, CTCF, HDAC2, MAZ, MXI1, NELFE, POLR2A, RBBP5, SMARCA4, SP3, SREBF1, SREBF2, SUPT20H, XRCC4	CEBPB, CUX1, E2F4, E2F6, EGR1, ELF1, ESRRA, ETS1, EZH2, GABPA, KAT2A, KLF3, KLF6, KLF15, KLF16, PATZ1, PBX3, POLR3G, RAD21, RCOR1, REST, SP1, SP2, SP4, TBX15, VEZF1, WT1, ZBTB7B, ZEB1, ZMIZ1, ZNF148, ZNF263, ZNF274, ZNF341, ZNF467	NaN	SP5, ZBTB17, ZNF16, ZNF23, ZNF84, ZNF189, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607	0.32371	0.0	861852.529441	688631.112	406723.0	4883.0
yetfasco__YHR178W_1405	Topic8	NaN	NaN	NaN	NaN	0.323703	0.0	838281.321397	669800.74	580863.0	4504.0
cisbp__M1767	Topic8	NaN	NaN	NaN	NaN	0.323426	0.0	846752.841886	676699.276	713971.0	3839.0
jaspar__MA0348.1	Topic8	NaN	NaN	NaN	NaN	0.323369	0.0	919346.248771	734742.894	379966.0	5551.0
transfac_pro__M01873	Topic8	EGR1	EGR2, EGR3, EGR4, WT1	NaN	NaN	0.323313	0.0	806866.995839	644874.358	542513.0	4404.0
dbcorrdb__SREBF2__ENCSR000EZO_1__m1	Topic8	BRF1, CTCF, ESRRA, EZH2, MXI1, POLR2A, SMARCA4, SREBF2, XRCC4, ZMIZ1, ZNF274	BRF2, CEBPB, CREB1, E2F1, E2F6, HCFC1, HDAC2, MAX, MYC, NELFE, POLR3G, RAD21, RBBP5, SREBF1, SUPT20H	NaN	NaN	0.323311	0.0	953744.851847	762264.644	151959.0	6478.0
hocomoco__KLF12_HUMAN.H11MO.0.C	Topic8	KLF12	IRF1, KLF3, KLF4, KLF5, KLF6, PBX3, SP1, SP2, SP3, SP4, STAT1	NaN	NaN	0.323195	0.0	847190.047031	677157.32	614829.0	4045.0
cisbp__M1812	Topic8	NaN	NaN	NaN	NaN	0.322927	0.0	839661.673686	671264.578	641997.0	4253.0
cisbp__M4728	Topic8	NaN	NaN	NaN	NaN	0.322558	0.0	969212.22784	775031.322	729359.0	4536.0
cisbp__M1771	Topic8	NaN	NaN	NaN	NaN	0.322451	0.0	824539.288993	659392.504	780579.0	3598.0
yetfasco__YBR150C_2179	Topic8	NaN	NaN	NaN	NaN	0.322299	0.0	830408.797882	664156.3	745713.0	3744.0
dbcorrdb__POLR2A__ENCSR000DMZ_1__m1	Topic8	POLR2A	BCLAF1, ELF1, ETS1, GABPA, HCFC1, TAF1	NaN	NaN	0.322187	0.0	946458.535241	757030.854	300493.0	5676.0
transfac_pro__M03207	Topic8	NaN	NaN	NaN	NaN	0.322182	0.0	919367.595007	735364.536	574006.0	4701.0
transfac_pro__M04817	Topic8	ZBTB33	CHD2	NaN	NaN	0.321803	0.0	846801.480519	677499.702	334482.0	5389.0
transfac_pro__M01588	Topic8	KLF4, KLF5	KLF10, KLF1, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17, KLF2, KLF3, KLF6, KLF7, KLF8, KLF9, SP1, SP3, SP8, SP9	NaN	SP6, SP7	0.321485	0.0	852781.829278	682434.85	666444.0	3878.0
taipale__SP1_DBD_GCCMCGCCCMC	Topic8	KLF13, KLF14, KLF15, SP1, SP8, SP9	CPSF4, FOS, IRF1, KLF10, KLF1, KLF11, KLF12, KLF16, KLF17, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, NFYB, PBX3, SP2, SP3, SP4, STAT1, TEAD2, WT1	NaN	EGR1, EGR2, EGR3, EGR4, KLF18, SP6, SP7	0.321151	0.0	836181.425293	669305.47	542979.0	4641.0
transfac_public__M00255	Topic8	NaN	FOS, IRF1, KLF12, KLF15, KLF16, KLF3, KLF4, KLF5, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4, SP8, STAT1	NaN	KLF17, KLF18, KLF7, SP6, SP7, SP9	0.320849	0.0	824811.99067	660343.116	521053.0	4755.0
yetfasco__YDR421W_2115	Topic8	NaN	NaN	NaN	NaN	0.320768	0.0	840601.261505	673021.782	788519.0	3421.0
cisbp__M6479	Topic8	SP1, SP2, SP3, SP4	CTCF, EGR1, EZH2, FOS, IRF1, KLF12, KLF15, KLF16, KLF3, KLF5, KLF9, NFYA, NFYB, PBX3, STAT1, TEAD2, WT1, ZNF281	NaN	SP6, SP7, SP8, SP9, ZBTB17	0.320641	0.0	790103.405371	632647.06	574781.0	4256.0
dbcorrdb__POLR2A__ENCSR000EFK_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.320588	0.0	900936.953222	721419.548	321720.0	5607.0
cisbp__M1723	Topic8	NaN	NaN	NaN	NaN	0.320317	0.0	816328.279536	653792.536	855502.0	2989.0
flyfactorsurvey__Deaf1_FlyReg_FBgn0013799	Topic8	NaN	NaN	DEAF1	NaN	0.320153	0.0	859516.481906	688459.754	713034.0	4216.0
jaspar__MA0312.1	Topic8	NaN	NaN	NaN	NaN	0.319901	0.0	930902.414828	745768.99	440805.0	5290.0
dbcorrdb__ZNF274__ENCSR000EVG_1__m3	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	BCLAF1, BHLHE40, CHD2, CREB1, E2F1, E2F4, E2F6, EGR1, ELF1, ELK4, ETS1, FOXP2, GABPA, HCFC1, HIC1, HMGN3, JUND, MAX, MAZ, MYC, NR2C2, NRF1, PHF8, SIN3A, SP1, SP2, SP3, SP4, TAF1, TFAP2A, TFAP2B, TFAP2C, TRIM28, UBTF, ZEB1, ZFX, ZNF143	NaN	ZFY	0.319861	0.000001	773500.997352	619688.018	826208.0	2970.0
taipale_cyt_meth__SP8_NCCACGCCCMYN_eDBD_meth	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP2, SP4	KLF17, KLF18	KLF12, KLF3, KLF7, KLF8, SP6, SP7	0.319843	0.0	880118.819695	705113.422	622758.0	4209.0
taipale_cyt_meth__KLF15_RCCACGCCCMYN_eDBD_meth	Topic8	KLF13, KLF14, KLF15, KLF16, SP3, SP8, SP9	FOS, IRF1, KLF11, KLF2, KLF3, KLF4, KLF5, KLF9, NFYA, NFYB, PBX3, SP1, SP2, SP4	KLF17, KLF18	KLF10, KLF12, KLF6, KLF7, KLF8, SP6, SP7	0.319663	0.0	868583.463245	695958.606	531806.0	4537.0
transfac_pro__M00695	Topic8	TEAD2	NaN	NaN	NaN	0.319638	0.0	787254.759929	630804.538	654092.0	4119.0
cisbp__M1719	Topic8	NaN	NaN	NaN	NaN	0.319632	0.0	876682.526794	702463.276	473886.0	4973.0
cisbp__M1829	Topic8	NaN	NaN	NaN	NaN	0.318973	0.0	834034.256966	668595.588	775914.0	3731.0
dbcorrdb__XRCC4__ENCSR000FAC_1__m1	Topic8	BRF1, BRF2, CEBPB, CTCF, E2F6, EGR1, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, RCOR1, SMARCA4, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TRIM28, XRCC4, ZMIZ1, ZNF274	BCLAF1, BHLHE40, CREB1, CUX1, E2F1, EGR4, ELF1, ELK1, ELK4, ETS1, FOS, GABPA, HCFC1, HIC1, IRF1, JUND, KAT2A, KLF16, KLF3, MAX, MYC, NFYB, NR2C2, PATZ1, PBX3, PHF8, REST, SIN3A, SP1, TAF1, TBX15, TFAP2B, UBTF, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZFX, ZNF143, ZNF263, ZNF460	NaN	ZBTB17, ZFY, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.318722	0.0	859392.800403	689044.012	353744.0	5102.0
cisbp__M1773	Topic8	NaN	NaN	NaN	NaN	0.318397	0.0	867471.090026	695677.72	491395.0	5421.0
cisbp__M1713	Topic8	NaN	NaN	NaN	NaN	0.318299	0.0	829349.294666	665150.318	882151.0	2885.0
transfac_pro__M07395	Topic8	SP1, SP3	CTCF, EGR1, EZH2, FOS, IRF1, KLF12, KLF15, KLF16, KLF3, KLF5, NFYA, NFYB, PBX3, SP2, SP4, STAT1, TEAD2, WT1	NaN	SP6, SP7, SP8, SP9	0.318079	0.0	779585.011474	625334.08	386554.0	5229.0
cisbp__M1736	Topic8	NaN	NaN	NaN	NaN	0.31798	0.0	807145.536502	647485.8	736809.0	3739.0
dbcorrdb__STAT1__ENCSR000DZM_1__m3	Topic8	STAT1	CTCF, FOS, IRF1, KLF12, KLF15, KLF5, MAZ, MXI1, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	NaN	CTCFL, SP6, SP7, SP8, SP9	0.317786	0.0	862949.362754	692344.254	321441.0	5567.0
transfac_pro__M09578	Topic8	NaN	TAF1	NaN	NaN	0.317723	0.0	875005.930021	702048.146	202889.0	6320.0
cisbp__M1716	Topic8	NaN	NaN	NaN	NaN	0.317704	0.0	848407.923339	680716.332	635576.0	4128.0
yetfasco__YGL162W_673	Topic8	NaN	NaN	NaN	NaN	0.317548	0.0	792239.223049	635718.314	193522.0	6524.0
dbcorrdb__POLR2A__ENCSR000EFB_1__m1	Topic8	POLR2A	TAF1	NaN	NaN	0.317515	0.0	910561.88816	730681.236	406144.0	5149.0
elemento__CGCCGCG	Topic8	NaN	NaN	NaN	NaN	0.316868	0.0	912834.834321	732833.94	120002.0	6795.0
transfac_pro__M07436	Topic8	WT1	BRF1, BRF2, CEBPB, EZH2, HDAC2, MAZ, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SP4, SREBF1, SREBF2, SUPT20H, XRCC4	NaN	NaN	0.316639	0.000001	789647.956248	634038.656	764134.0	3362.0
taipale_cyt_meth__KLF14_NRCCACGCCCMYN_eDBD_meth	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP2	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP4, SP6, SP7	0.316463	0.0	837467.232505	672516.542	706161.0	3840.0
cisbp__M1761	Topic8	NaN	NaN	NaN	NaN	0.316246	0.0	892009.814273	716423.91	758214.0	3810.0
yetfasco__YLR451W_781	Topic8	NaN	NaN	NaN	NaN	0.315957	0.0	846968.15244	680384.832	813843.0	3499.0
transfac_pro__M05165	Topic8	NaN	NaN	NaN	NaN	0.315916	0.0	994303.324423	798764.33	158716.0	6564.0
cisbp__M0495	Topic8	NaN	NaN	NaN	KLF15, SP4	0.315782	0.0	864761.428698	694762.804	236567.0	6238.0
cisbp__M1759	Topic8	NaN	NaN	NaN	NaN	0.315711	0.0	909207.360989	730506.934	415366.0	5413.0
predrem__nrMotif1417	Topic8	NaN	CEBPB, CTCF, EGR1, ESRRA, NFYB, PBX3, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, WT1, XRCC4	NaN	NaN	0.315286	0.0	911582.596898	732631.194	455761.0	4991.0
scertf__spivak.LEU3	Topic8	NaN	NaN	NaN	NaN	0.315263	0.0	889752.028874	715097.588	584176.0	4416.0
transfac_pro__M03198	Topic8	NaN	NaN	NaN	NaN	0.315211	0.0	976414.629681	784777.04	268305.0	6093.0
dbcorrdb__TAF1__ENCSR000BIM_1__m1	Topic8	KDM5A, POLR2A, TAF1, TAF7, YY1	ATF3, KDM5B, RBBP5	NaN	TAF1L	0.31486	0.0	920508.290884	740023.54	307162.0	5677.0
swissregulon__sacCer__TBS1	Topic8	NaN	NaN	NaN	NaN	0.314402	0.0	935196.090026	752069.966	348439.0	5706.0
cisbp__M6480	Topic8	FOS, IRF1, KLF3, NFYB, PBX3, SP1, SP2, SP3, SP4	BRF1, BRF2, CTCF, CUX1, EGR1, EGR2, EGR3, EGR4, ESRRA, EZH2, HDAC2, KLF1, KLF12, KLF14, KLF15, KLF16, KLF5, KLF6, KLF9, MAZ, MXI1, NELFE, NFYA, PATZ1, RAD21, RBBP5, RCOR1, REST, SMARCA4, SREBF1, SREBF2, STAT1, SUPT20H, VEZF1, WT1, XRCC4, ZBTB7A, ZBTB7B, ZNF148, ZNF219, ZNF281, ZNF467, ZNF740	NaN	KLF17, KLF18, KLF4, SP5, SP6, SP7, SP8, SP9, ZBTB17	0.314342	0.0	805046.597655	647432.752	484005.0	4636.0
transfac_pro__M03194	Topic8	NaN	NaN	NaN	NaN	0.314266	0.0	932972.783508	750352.852	243929.0	6047.0
yetfasco__YBL005W_1387	Topic8	NaN	NaN	NaN	NaN	0.314215	0.0	826062.727777	664392.586	592630.0	4518.0
taipale_cyt_meth__KLF2_NRCCACRCCCN_eDBD	Topic8	KLF2, KLF4, KLF6	KLF12, KLF13, KLF14, KLF16, KLF3, KLF5, SP1, SP3, SP8, SP9	KLF7	KLF10, KLF1, KLF11, KLF17, KLF18, KLF8, SP6, SP7	0.313414	0.0	817404.354306	657794.234	982687.0	2585.0
cisbp__M6483	Topic8	BRF1, BRF2, ESRRA, HDAC2, MXI1, NELFE, POLR2A, RBBP5, SMARCA4, SP4, SREBF1, SREBF2, SUPT20H, XRCC4	CEBPB, CTCF, CUX1, E2F6, EGR1, EZH2, FOS, KLF11, KLF15, KLF16, KLF3, KLF5, MAX, MAZ, MYC, PATZ1, RAD21, RCOR1, REST, SP1, SP2, SP3, TBX15, WT1, ZBTB7A, ZBTB7B, ZMIZ1, ZNF274, ZNF460, ZNF467	NaN	ZBTB17	0.313402	0.0	929469.695625	747983.018	484668.0	5092.0
cisbp__M1742	Topic8	NaN	NaN	NaN	NaN	0.313234	0.0	898922.672677	723484.714	677857.0	4198.0
transfac_pro__M00932	Topic8	FOS, IRF1, PBX3, SP1, SP2, SP3, SP4	KLF12, KLF13, KLF14, KLF15, KLF16, KLF2, KLF3, KLF4, KLF5, KLF9, MAZ, NFYA, NFYB, PATZ1, SP8, SP9, STAT1	NaN	KLF17, KLF18, SP6, SP7	0.313181	0.0	780796.358467	628435.582	556644.0	4336.0
yetfasco__YDL002C_502	Topic8	NaN	NaN	NaN	NaN	0.312912	0.0	878663.546715	707337.5	282125.0	5989.0
jaspar__MA0311.1	Topic8	NaN	NaN	NaN	NaN	0.312652	0.0	959144.214475	772265.032	325873.0	5634.0
cisbp__M3926	Topic8	PBX3, SP1, SP2, SP3, SP4	CTCF, EZH2, FOS, IRF1, KLF12, KLF13, KLF14, KLF15, KLF16, KLF2, KLF3, KLF5, KLF9, MAZ, NFYA, NFYB, SP8, SP9, STAT1	NaN	KLF17, KLF18, SP6, SP7	0.312289	0.0	788148.536755	634745.842	490439.0	4624.0
cisbp__M4871	Topic8	NaN	FOS, IRF1, KLF12, KLF13, KLF14, KLF15, KLF16, KLF4, KLF5, KLF9, NFYA, NFYB, PBX3, SP8, SP9, STAT1	SP1, SP2, SP3, SP4	E2F4, KLF10, KLF11, KLF17, KLF18, KLF3, KLF6, KLF7, KLF8, SP6, SP7	0.31228	0.0	880354.944648	709009.542	682353.0	3974.0
transfac_pro__M03205	Topic8	NaN	NaN	NaN	NaN	0.311974	0.0	902121.130122	726693.532	404103.0	5209.0
cisbp__M1731	Topic8	NaN	NaN	NaN	NaN	0.311742	0.0	794828.160635	640367.83	608860.0	4051.0
dbcorrdb__EZH2__ENCSR000ARK_1__m2	Topic8	EZH2	NaN	NaN	NaN	0.311702	0.0	910970.69386	733960.404	788663.0	3967.0
dbcorrdb__EZH2__ENCSR000ASE_1__m1	Topic8	EZH2	ATF3, BRF1, CTCF, E2F6, HDAC2, MXI1, POLR2A, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.311527	0.0	898748.477241	724201.12	321399.0	5570.0
transfac_pro__M05071	Topic8	NaN	NaN	NaN	NaN	0.311036	0.0	979155.373219	789260.51	242824.0	6223.0
dbcorrdb__POLR2A__ENCSR000DLQ_1__m2	Topic8	POLR2A	ELK4, ESRRA, EZH2, GABPA, SMARCA4, SREBF1, SREBF2, XRCC4, ZMIZ1	NaN	NaN	0.310962	0.0	945554.939226	762215.54	303020.0	5847.0
hocomoco__E2F4_MOUSE.H11MO.0.A	Topic8	NaN	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP4, TFDP1	E2F4	E2F1, SP3, SP6, SP7, SP8, SP9	0.310913	0.0	831657.497541	670425.208	818347.0	3259.0
jaspar__MA1002.1	Topic8	NaN	ATF3, KDM5A, TAF1, YY1	NaN	NaN	0.310819	0.0	819575.315345	660728.444	547500.0	4532.0
jaspar__MA0292.1	Topic8	NaN	NaN	NaN	NaN	0.310756	0.0	890290.381415	717769.394	641068.0	4429.0
dbcorrdb__SIN3A__ENCSR000BOW_1__m2	Topic8	SIN3A	E2F4, MAX, SAP30	NaN	NaN	0.310745	0.0	887324.222418	715383.034	341732.0	5596.0
transfac_pro__M07520	Topic8	NaN	HCFC1, ZMIZ1, ZNF66	NaN	NaN	0.310583	0.0	956908.945656	771571.004	366401.0	5657.0
transfac_pro__M03189	Topic8	NaN	NaN	NaN	NaN	0.310569	0.0	973278.936452	784777.778	200366.0	6337.0
dbcorrdb__POLR2A__ENCSR000BMR_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, PML, POLR2A, SIN3A, TAF1	BHLHE40, E2F6, EGR1, ELF2, ELK1, ELK3, ESRRA, ETV1, ETV6, EZH2, FEV, FOXP2, GABPB1, KDM5B, MAX, MXI1, RBBP5, RELA, SREBF2, SRF, UBTF, XRCC4, ZMIZ1, ZNF143, ZNF274	FLI1	ERG	0.309877	0.0	952364.202749	768282.366	231365.0	6163.0
transfac_pro__M01622	Topic8	NaN	NaN	NaN	NaN	0.309849	0.0	873513.156222	704685.91	356964.0	5458.0
dbcorrdb__POLR2A__ENCSR000DMT_1__m1	Topic8	POLR2A	PML, TAF1, THAP1	NaN	NaN	0.30916	0.0	929166.104274	749940.452	668089.0	4498.0
dbcorrdb__E2F6__ENCSR000EWJ_1__m2	Topic8	E2F6	EZH2, MAX, MXI1, MYC, USF2	NaN	NaN	0.309159	0.0	955902.572563	771520.57	494079.0	5211.0
jaspar__MA0352.1	Topic8	NaN	NaN	NaN	NaN	0.308565	0.0	851366.016391	687430.6	627378.0	4384.0
dbcorrdb__SIN3A__ENCSR000BGL_1__m2	Topic8	SIN3A	NaN	NaN	NaN	0.308513	0.0	917759.387089	741066.614	411535.0	5200.0
elemento__CCCGCCG	Topic8	NaN	NaN	NaN	NaN	0.308242	0.0	872998.856386	705055.81	287257.0	5710.0
dbcorrdb__FOS__ENCSR000FAI_1__m2	Topic8	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	BRF2, EGR1, EGR2, EGR3, EGR4, EZH2, KLF15, KLF3, KLF5, KLF9, MAZ, MXI1, SREBF1, STAT1, XRCC4, ZBTB7A	NaN	E2F4, SP5, SP6, SP7, SP8, SP9, ZBTB17	0.308176	0.0	879995.095953	710739.012	244667.0	6029.0
hocomoco__KLF1_HUMAN.H11MO.0.A	Topic8	KLF1, KLF3, KLF6	EGR1, EGR2, EGR3, EGR4, IRF1, KLF2, KLF4, KLF5, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, MAZ, NFYA, PBX3, SP1, SP2, SP3, SP4	NaN	NaN	0.307912	0.0	844604.22204	682279.618	539660.0	4430.0
elemento__CCGCCTC	Topic8	NaN	NaN	NaN	NaN	0.30775	0.000001	849532.577859	686338.068	555024.0	4356.0
dbcorrdb__KAT2A__ENCSR000ECR_1__m1	Topic8	KAT2A	BRF1, BRF2, CTCF, CUX1, EGR1, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SREBF1, SREBF2, SUPT20H, XRCC4	NaN	SP1, ZBTB17	0.307655	0.0	827516.533854	668595.23	349048.0	5339.0
taipale_cyt_meth__SP9_NCCACGCCCMYN_eDBD	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF11, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP2, SP4	KLF17, KLF18	KLF10, KLF12, KLF3, KLF7, KLF8, SP6, SP7	0.307626	0.0	839211.210188	678057.602	681678.0	3845.0
dbcorrdb__POLR2A__ENCSR000DPC_1__m1	Topic8	POLR2A	EZH2, PML, SIN3A, TAF1	NaN	NaN	0.307362	0.0	918330.614803	742119.586	410250.0	5176.0
dbcorrdb__POLR2A__ENCSR000BHH_1__m1	Topic8	BCLAF1, ELF1, ETS1, GABPA, HCFC1, PHF8, PML, POLR2A, RBBP5, SIN3A	BHLHE40, BRF1, CEBPB, CTCF, E2F1, E2F6, ELK1, ELK4, ESRRA, EZH2, FOXP2, HDAC2, MAX, MXI1, MYC, NELFE, NRF1, SMARCA4, SREBF1, SREBF2, SUPT20H, TAF1, THAP1, XRCC4, ZMIZ1, ZNF143, ZNF274	NaN	FLI1	0.307333	0.0	939126.072879	758939.848	218900.0	6116.0
jaspar__MA0405.1	Topic8	NaN	NaN	NaN	NaN	0.307269	0.0	873922.523137	706278.338	307309.0	5725.0
jaspar__MA0992.1	Topic8	NaN	NaN	NaN	TAF1, TAF1L	0.30709	0.0	852275.450132	688868.974	343911.0	5381.0
transfac_pro__M07533	Topic8	NaN	NaN	NaN	NaN	0.307005	0.0	871309.39541	704295.248	445280.0	4890.0
dbcorrdb__ZNF143__ENCSR000EBW_1__m3	Topic8	ZNF143	ATF3, EZH2, MXI1, MYC, POLR2A, ZMIZ1	NaN	NaN	0.306958	0.0	843887.545202	682151.94	466265.0	4646.0
transfac_pro__M01914	Topic8	NaN	NaN	NaN	NaN	0.306888	0.0	919549.534737	743348.618	377324.0	5560.0
dbcorrdb__SIX5__ENCSR000BJE_1__m3	Topic8	SIX5	NaN	NaN	NaN	0.306702	0.0	916007.113353	740580.698	415223.0	5166.0
yetfasco__YBR239C_2188	Topic8	NaN	NaN	NaN	NaN	0.306624	0.0	870979.48178	704214.374	531074.0	5256.0
yetfasco__YPL248C_1510	Topic8	NaN	NaN	NaN	NaN	0.306609	0.0	895378.576094	723949.366	594648.0	4394.0
hocomoco__MECP2_HUMAN.H11MO.0.C	Topic8	MECP2	NaN	NaN	NaN	0.306353	0.0	924066.346488	747277.004	346651.0	5733.0
cisbp__M6127	Topic8	KLF5	KLF1, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, KLF2, KLF3, KLF6, KLF7, KLF8, KLF9	KLF4	SP1, SP2, SP3, SP4, SP6, SP7, SP8, SP9	0.306059	0.000001	838780.396167	678446.234	900053.0	2985.0
cisbp__M5210	Topic8	KLF9	FOS, IRF1, KLF12, KLF13, KLF14, KLF15, KLF16, KLF2, KLF3, KLF4, KLF5, KLF6, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4, STAT1	SP6, SP7, SP8, SP9	E2F4, KLF10, KLF11, KLF17, KLF18, KLF7, KLF8	0.306049	0.0	847419.262388	685438.498	534948.0	4669.0
predrem__nrMotif1451	Topic8	NaN	POLR2A, XRCC4	NaN	NaN	0.305939	0.0	912470.209431	738111.134	522364.0	4775.0
cisbp__M1718	Topic8	NaN	NaN	NaN	NaN	0.305903	0.0	847185.040726	685318.25	801170.0	3366.0
elemento__CCGCCCC	Topic8	NaN	SP3	NaN	NaN	0.305833	0.0	814593.894086	658985.888	552941.0	4281.0
dbcorrdb__POLR2A__ENCSR000FAL_1__m1	Topic8	GABPA, PML, POLR2A, TAF1	BCLAF1, E2F6, ELF1, ELK4, ETS1, EZH2, GTF2F1, HCFC1, MAX, MXI1, NR2C2, PHF8, SIN3A	NaN	NaN	0.305609	0.0	953978.161392	771864.544	248828.0	6034.0
transfac_pro__M01648	Topic8	NaN	NaN	NaN	NaN	0.30559	0.0	923979.561089	747602.358	411562.0	5406.0
swissregulon__hs__SP1.p2	Topic8	SP1, SP2, SP3, SP4	BRF1, BRF2, CTCF, EGR1, ESRRA, EZH2, FOS, IRF1, KLF3, KLF5, KLF6, KLF12, KLF13, KLF14, KLF15, KLF16, MAZ, NELFE, NFYA, NFYB, PATZ1, PBX3, POLR2A, RBBP5, SMARCA4, SP9, SREBF1	NaN	KLF17, KLF18, SP6, SP7, SP8	0.305452	0.0	823124.324171	666062.916	574380.0	4197.0
predrem__nrMotif891	Topic8	NaN	NaN	NaN	NaN	0.305254	0.0	925940.86206	749363.626	383435.0	5405.0
cisbp__M1776	Topic8	NaN	NaN	NaN	NaN	0.304898	0.0	833602.270962	674800.606	559319.0	4133.0
yetfasco__YCR106W_506	Topic8	NaN	NaN	NaN	NaN	0.304867	0.0	855611.256084	692631.6	314254.0	5653.0
dbcorrdb__EZH2__ENCSR000ARR_1__m1	Topic8	EZH2	NaN	NaN	NaN	0.30483	0.0	889411.276888	720011.704	270654.0	5886.0
yetfasco__YPL133C_2226	Topic8	NaN	NaN	NaN	NaN	0.304265	0.0	853784.564746	691441.598	505414.0	5108.0
dbcorrdb__POLR2A__ENCSR000DKM_1__m1	Topic8	POLR2A	E2F6, ELF1, ETS1, GABPA, NRF1, PML, TAF1	NaN	NaN	0.304236	0.0	939825.30198	761137.38	601140.0	4842.0
dbcorrdb__EZH2__ENCSR000ASW_1__m4	Topic8	EZH2	BRF1, CTCF, ESRRA, GABPA, MXI1, RAD21, SMARCA4, SP2, SREBF1, SREBF2, XRCC4	NaN	NaN	0.304134	0.0	867878.815408	702919.572	474536.0	4574.0
dbcorrdb__SP1__ENCSR000BHK_1__m2	Topic8	IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	EGR1, ESRRA, FOS, KLF12, KLF15, KLF3, KLF5, KLF6, KLF9, MAZ, PATZ1, RAD21, STAT1	NaN	E2F4, KLF17, KLF18, SP6, SP7, SP8, SP9	0.303985	0.0	891567.712647	722180.374	412811.0	5059.0
hocomoco__KLF1_MOUSE.H11MO.0.A	Topic8	KLF1, KLF3, KLF4, KLF5	EGR1, EGR2, EGR3, EGR4, IRF1, KLF2, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, PBX3, SP1, SP2, SP3	NaN	SP4	0.303874	0.000001	855302.868365	692858.99	602738.0	4158.0
yetfasco__YOR380W_2158	Topic8	NaN	NaN	NaN	NaN	0.303845	0.0	844782.254318	684350.008	693098.0	4223.0
predrem__nrMotif985	Topic8	NaN	NaN	NaN	NaN	0.30376	0.0	937355.088892	759387.118	359351.0	5603.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BOA_1__m1	Topic8	POLR2A, TAF1	ELF1, ELF2, ELK1, ELK4, ETV1, ETV6, GABPA, GABPB1, PML	NaN	FLI1	0.303729	0.0	935057.915269	757542.668	462403.0	5089.0
cisbp__M0481	Topic8	NaN	NaN	NaN	NaN	0.303631	0.000002	869047.295045	704111.56	966556.0	2999.0
dbcorrdb__SIN3A__ENCSR000BOW_1__m3	Topic8	SIN3A	ATF3, BHLHE40, USF2	NaN	NaN	0.303627	0.0	901016.958391	730015.672	362237.0	5438.0
dbcorrdb__POLR2AphosphoS2__ENCSR000ECT_1__m1	Topic8	POLR2A, TAF1	ATF1, BCLAF1, ELF1, ELK4, ETS1, GABPA, GTF2F1, HCFC1, PHF8, PML, SIN3A	NaN	FLI1	0.302857	0.0	950488.640398	770509.312	299543.0	5782.0
dbcorrdb__RBBP5__ENCSR000AQI_1__m1	Topic8	BCLAF1, ETS1, GABPA, HCFC1, POLR2A, RBBP5, SIN3A, TAF1, YY1	E2F6, ELF1, ELK1, ELK4, EZH2, KDM5A, KDM5B, MXI1, MYC, PHF8, PML, ZMIZ1	NaN	NaN	0.302502	0.0	954888.102635	774266.06	320626.0	5831.0
cisbp__M1738	Topic8	NaN	NaN	NaN	NaN	0.302485	0.0	930786.039087	754732.226	588781.0	4637.0
cisbp__M2329	Topic8	NaN	NaN	SMAD1, SMAD5, SMAD9	NaN	0.302471	0.0	957632.036439	776507.854	459122.0	5342.0
yetfasco__YPL248C_2206	Topic8	NaN	NaN	NaN	NaN	0.302451	0.0	849021.381793	688449.08	709020.0	3839.0
dbcorrdb__POLR2A__ENCSR000EEP_1__m1	Topic8	POLR2A	ETS1, EZH2, HCFC1, ZNF143	NaN	NaN	0.302346	0.0	942078.958517	763962.468	185118.0	6318.0
hocomoco__SP4_HUMAN.H11MO.1.A	Topic8	NFYB, PBX3, SP1, SP2, SP3, SP4	EGR1, FOS, IRF1, KLF3, KLF5, KLF6, KLF9, KLF12, KLF15, MAZ, NFYA, PATZ1, STAT1, ZNF148, ZNF281	NaN	KLF17, KLF18, SP5, SP6, SP7, SP8, SP9, ZBTB17	0.302238	0.000003	834428.263649	676715.912	734421.0	3576.0
cisbp__M4220	Topic8	NaN	NaN	NaN	NaN	0.302144	0.0	879788.670407	713549.33	310055.0	5832.0
dbcorrdb__BRF2__ENCSR000DNV_1__m2	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	CREB1, CUX1, E2F6, EGR1, EGR2, EGR3, EGR4, ELK1, FOS, GABPA, HIC1, IRF1, KAT2A, KLF16, KLF3, KLF5, MAX, MYC, NFYB, NR2C2, PBX3, POLR3G, RCOR1, REST, SP1, SP2, SP3, TBX15, WRNIP1, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZFX, ZNF263, ZNF460	NaN	ZBTB17, ZFY, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.301914	0.0	804035.392384	652213.688	592594.0	3864.0
cisbp__M1289	Topic8	NaN	NaN	NaN	NaN	0.301653	0.0	913388.514059	741052.246	425063.0	5175.0
cisbp__M1746	Topic8	NaN	NaN	NaN	NaN	0.301589	0.0	818613.916656	664189.312	611387.0	4448.0
transfac_pro__M03206	Topic8	NaN	NaN	NaN	NaN	0.301297	0.0	910024.10377	738505.208	234698.0	6212.0
elemento__CCGCCGC	Topic8	NaN	NaN	NaN	NaN	0.301149	0.0	865544.801412	702480.914	284579.0	5711.0
predrem__nrMotif1136	Topic8	NaN	ESRRA, KLF3, SP1, SP2	NaN	NaN	0.300775	0.0	934293.869752	758475.038	348738.0	5455.0
dbcorrdb__POLR2A__ENCSR000BJM_1__m1	Topic8	ELF1, GABPA, PHF8, PML, POLR2A	BCLAF1, ELK4, ESRRA, ETS1, EZH2, GTF2F1, HCFC1, MXI1, NRF1, RBBP5, SIN3A, TAF1, ZNF143	NaN	FLI1	0.300772	0.0	923162.554659	749439.748	555986.0	4829.0
swissregulon__sacCer__RDS1	Topic8	NaN	NaN	NaN	NaN	0.300685	0.0	939421.180053	762684.766	241642.0	6198.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIA_1__m2	Topic8	NaN	NaN	NaN	NaN	0.30052	0.0	919123.741647	746291.62	359931.0	5342.0
dbcorrdb__NFYA__ENCSR000DNS_1__m2	Topic8	NFYA, SP1	FOS, IRF1, KLF5, MAZ, NFYB, PBX3, SP2, SP3, SP4, STAT1	NaN	E2F4, SP6, SP7, SP8, SP9	0.300413	0.0	924514.827512	750724.218	315398.0	5562.0
dbcorrdb__POLR2A__ENCSR000DKM_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.299878	0.0	951938.213214	773279.742	320312.0	5738.0
transfac_pro__M07937	Topic8	KLF12, KLF2, KLF4, KLF5	KLF10, KLF1, KLF11, KLF13, KLF14, KLF15, KLF16, KLF3, KLF9, SP1, SP3, SP4, SP8, SP9	KLF6, KLF7, KLF8	KLF17, KLF18, SP2, SP6, SP7	0.299767	0.000001	844648.182196	686178.326	904733.0	2978.0
scertf__zhu.TBS1	Topic8	NaN	NaN	NaN	NaN	0.299751	0.0	991968.05447	805867.686	702654.0	4781.0
yetfasco__YER184C_2095	Topic8	NaN	NaN	NaN	NaN	0.299728	0.0	907958.154331	737630.128	290636.0	5941.0
dbcorrdb__RAD21__ENCSR000BLY_1__m3	Topic8	MXI1, NELFE, RAD21, SMARCA4, SREBF1	BRF1, BRF2, CEBPB, CTCF, EGR1, ESRRA, EZH2, HDAC2, HIC1, KLF16, MAX, MAZ, POLR2A, RBBP5, SP4, SREBF2, SUPT20H, XRCC4, ZBTB7A, ZMIZ1, ZNF274	NaN	NaN	0.299507	0.000001	829954.856765	674363.31	651626.0	3845.0
taipale_cyt_meth__SP3_NRCCMCGCCCMYN_eDBD_meth	Topic8	KLF13, KLF14, KLF15, SP3, SP8, SP9	KLF10, KLF11, KLF12, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP2, SP4	KLF17, KLF18	KLF3, KLF7, KLF8, SP6, SP7	0.299375	0.0	888464.010717	721969.798	558935.0	4511.0
cisbp__M1503	Topic8	NaN	NaN	NaN	NaN	0.298964	0.0	889015.75249	722623.854	488196.0	4773.0
transfac_pro__M05013	Topic8	NaN	NaN	NaN	NaN	0.298889	0.0	1003156.088387	815443.662	159946.0	6608.0
transfac_pro__M03172	Topic8	NaN	NaN	NaN	NaN	0.298789	0.0	954036.118144	775568.926	611355.0	4774.0
dbcorrdb__HDAC1__ENCSR000AQF_1__m3	Topic8	HDAC1	NaN	NaN	NaN	0.298784	0.0	908165.204262	738281.534	375376.0	5198.0
cisbp__M1735	Topic8	NaN	NaN	NaN	NaN	0.298505	0.0	857400.585172	697147.634	501775.0	5119.0
transfac_pro__M03201	Topic8	NaN	NaN	NaN	NaN	0.29849	0.0	883935.165553	718730.132	349756.0	5735.0
cisbp__M0609	Topic8	DNMT1	NaN	NaN	NaN	0.297856	0.0	809996.747573	658900.46	370146.0	5811.0
elemento__CCGCGCC	Topic8	NaN	NaN	NaN	NaN	0.297843	0.0	874072.131383	711029.618	359048.0	5405.0
flyfactorsurvey__CG5669_SANGER_10_FBgn0039169	Topic8	NaN	FOS, IRF1, KLF4, KLF5, KLF9, KLF12, KLF14, KLF15, KLF16, NFYA, NFYB, PBX3, SP8, SP9, STAT1	SP1, SP2, SP3, SP4	E2F4, KLF3, KLF7, KLF8, KLF10, KLF11, KLF17, KLF18, SP6, SP7	0.29773	0.0	884990.540033	719967.632	550239.0	4520.0
cisbp__M4359	Topic8	NaN	NaN	NaN	NaN	0.297692	0.0	842490.939478	685410.906	486619.0	5076.0
transfac_pro__M05068	Topic8	NaN	NaN	NaN	NaN	0.29765	0.0	994806.140714	809351.166	710198.0	4826.0
transfac_pro__M02810	Topic8	NaN	FOS, IRF1, KLF13, KLF14, KLF15, KLF9, NFYA, NFYB, PBX3, SP1, SP2, SP3, STAT1	SP4	E2F4, SP6, SP7, SP8, SP9	0.297104	0.0	911061.081705	741498.628	485807.0	4826.0
transfac_pro__M01303	Topic8	SP1	CTCF, ZBTB7B	NaN	NaN	0.297025	0.000001	789759.878199	642808.624	547481.0	4402.0
cisbp__M2272	Topic8	E2F1, E2F4	E2F6	NaN	E2F3	0.296548	0.000001	903435.75476	735575.9	715471.0	4202.0
jaspar__MA1000.1	Topic8	NaN	NaN	NaN	NaN	0.296054	0.0	971303.279158	791104.434	155266.0	6568.0
dbcorrdb__SIX5__ENCSR000BRL_1__m2	Topic8	SIX5	NaN	NaN	NaN	0.295964	0.0	927384.563989	755380.568	552245.0	4799.0
yetfasco__YMR019W_2107	Topic8	NaN	NaN	NaN	NaN	0.295948	0.0	933539.216871	760401.946	386389.0	5422.0
elemento__CGCGCGC	Topic8	NaN	NaN	NaN	NaN	0.295833	0.0	947900.006178	772161.024	174593.0	6575.0
dbcorrdb__EZH2__ENCSR000ARI_1__m4	Topic8	EZH2	HCFC1, POLR2A	NaN	NaN	0.295655	0.0	854809.894213	696415.702	588153.0	4485.0
yetfasco__YOL089C_2134	Topic8	NaN	NaN	NaN	NaN	0.295621	0.0	846877.015257	689968.876	1018841.0	2627.0
dbcorrdb__EZH2__ENCSR000ARO_1__m1	Topic8	EZH2	NaN	NaN	NaN	0.295485	0.0	915211.0145	745712.35	731590.0	4134.0
transfac_pro__M03199	Topic8	NaN	NaN	NaN	NaN	0.295297	0.0	896492.027613	730555.484	419962.0	5179.0
elemento__CCCGCCC	Topic8	NaN	FOS	NaN	NaN	0.295241	0.000001	807462.857521	658030.77	500438.0	4513.0
homer__CCCCGCGC_SUT1_	Topic8	NaN	NaN	NaN	NaN	0.295131	0.0	783226.411045	638328.182	589497.0	4413.0
transfac_pro__M01960	Topic8	NaN	NaN	NaN	NaN	0.294984	0.0	932278.655781	759883.138	1039877.0	3394.0
cisbp__M1757	Topic8	NaN	NaN	NaN	NaN	0.294905	0.0	889316.537763	724904.976	392059.0	5161.0
cisbp__M6339	Topic8	MECP2	NaN	NaN	NaN	0.294843	0.0	915115.993065	745967.036	277288.0	6031.0
jaspar__MA0980.1	Topic8	NaN	HCFC1	NaN	NaN	0.294244	0.0	874105.702181	712833.014	406809.0	5097.0
transfac_pro__M05024	Topic8	NaN	NaN	NaN	NaN	0.294238	0.0	1004694.908713	819331.922	461381.0	5722.0
swissregulon__sacCer__NHP10	Topic8	NaN	NaN	NaN	NaN	0.294047	0.0	884663.567394	721541.118	329001.0	5700.0
cisbp__M0040	Topic8	NaN	NaN	NaN	NaN	0.293984	0.0	918125.683646	748866.162	375666.0	5355.0
dbcorrdb__TBP__ENCSR000ECB_1__m3	Topic8	TBP	NaN	NaN	NaN	0.293812	0.0	948288.601311	773560.658	524377.0	4955.0
hocomoco__KLF4_HUMAN.H11MO.0.A	Topic8	KLF4, KLF5	KLF1, KLF2, KLF3, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, SP1	NaN	SP4	0.293777	0.000002	848167.774808	691904.254	837558.0	3287.0
transfac_pro__M07517	Topic8	NaN	NaN	NaN	NaN	0.293634	0.0	859533.202118	701245.592	398911.0	5232.0
dbcorrdb__UBTF__ENCSR000EFZ_1__m1	Topic8	UBTF	BRF1, EZH2, MAZ, MXI1, POLR2A, SMARCA4, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.293599	0.000001	826614.091918	674405.098	376926.0	5138.0
jaspar__MA0428.1	Topic8	NaN	NaN	NaN	NaN	0.29348	0.0	929897.618333	758732.794	442114.0	5274.0
dbcorrdb__ZC3H11A__ENCSR000EFR_1__m3	Topic8	ZC3H11A	BRF1, BRF2, CEBPB, CTCF, CTCFL, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, RXRA, SMARCA4, SREBF1, SREBF2, XRCC4, ZMIZ1	NaN	NaN	0.293473	0.000001	806098.33451	657724.404	491326.0	4492.0
cisbp__M1831	Topic8	NaN	NaN	NaN	NaN	0.293386	0.0	861849.543437	703255.962	534259.0	4993.0
cisbp__M1786	Topic8	NaN	NaN	NaN	NaN	0.293377	0.0	905228.859791	738657.404	566509.0	4632.0
cisbp__M1620	Topic8	NaN	NaN	NaN	NaN	0.292973	0.0	881398.612281	719413.494	361018.0	5485.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BPI_1__m1	Topic8	NaN	POLR2A	NaN	NaN	0.292818	0.000001	939530.098348	766943.84	343043.0	5583.0
cisbp__M5593	Topic8	KLF15, KLF16, KLF9	IRF1, KLF10, KLF11, KLF13, KLF14, KLF2, KLF4, KLF5, SP1, SP2, SP3, SP4, SP8, SP9	NaN	KLF12, KLF17, KLF18, KLF6, KLF7, KLF8, SP6, SP7	0.292659	0.000002	835754.676838	682306.63	801280.0	3334.0
predrem__nrMotif1357	Topic8	NaN	CEBPB, NELFE, POLR3G, SP4	NaN	NaN	0.2926	0.000001	926804.317362	756670.378	613776.0	4630.0
dbcorrdb__POLR2A__ENCSR000DLV_1__m2	Topic8	GTF2F1, POLR2A, TAF1, TBP	GTF2B	NaN	NaN	0.292565	0.0	894851.481654	730600.876	585969.0	4508.0
cisbp__M2360	Topic8	NaN	NaN	NaN	NaN	0.292493	0.000001	855604.555037	698592.336	624768.0	4093.0
dbcorrdb__RBBP5__ENCSR000AQC_1__m4	Topic8	RBBP5	NaN	NaN	NaN	0.292267	0.0	890234.534359	726981.634	291159.0	5824.0
transfac_pro__M07397	Topic8	ZNF148	CTCF, MAZ, SP1, SP2, SP3, SP4	NaN	ZNF281	0.292131	0.000006	805753.943135	658055.008	774686.0	3438.0
predrem__nrMotif1594	Topic8	NaN	NaN	NaN	NaN	0.292115	0.0	920063.196066	751418.974	417835.0	5168.0
dbcorrdb__ELK4__ENCSR000EVB_1__m3	Topic8	ELK4	NaN	NaN	NaN	0.291971	0.0	849507.257597	693865.326	604432.0	4189.0
factorbook__SP1	Topic8	FOS, IRF1, NFYA, PBX3, SP1, SP2, SP3, SP4	KLF1, KLF3, KLF5, KLF6, KLF9, KLF12, KLF14, KLF15, MAZ, NFYB, SP8, STAT1	NaN	E2F4, KLF17, KLF18, SP6, SP7, SP9	0.291967	0.0	834745.661329	681810.004	605273.0	4204.0
dbcorrdb__MXI1__ENCSR000EFE_1__m2	Topic8	MXI1	BCLAF1, ELF1, ELK1, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, TAF1	NaN	NaN	0.291846	0.000002	838101.461228	684608.514	719725.0	3555.0
dbcorrdb__FOSL1__ENCSR000BNS_1__m2	Topic8	FOSL1	NaN	NaN	NaN	0.291386	0.0	813609.713403	664814.016	441794.0	4909.0
dbcorrdb__TAF1__ENCSR000BPF_1__m1	Topic8	POLR2A, TAF1	BCLAF1, ELK4, GABPA, PML	NaN	FLI1	0.291336	0.0	982036.556676	802466.378	414049.0	5619.0
taipale_cyt_meth__KLF14_NRCCACGCCCMYN_eDBD	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF12, KLF16, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, PBX3, SP2, SP4	KLF17, KLF18	KLF10, KLF11, KLF7, KLF8, SP6, SP7	0.291257	0.000001	831050.070735	679125.622	771892.0	3448.0
transfac_pro__M03202	Topic8	NaN	NaN	NaN	NaN	0.291219	0.0	918620.480015	750706.974	310943.0	5538.0
yetfasco__YKL015W_2223	Topic8	NaN	NaN	NaN	NaN	0.290904	0.0	840647.92813	687136.992	675480.0	4136.0
elemento__CGCCGCC	Topic8	NaN	NaN	NaN	NaN	0.29051	0.0	862030.688438	704807.398	380969.0	5343.0
jaspar__MA0394.1	Topic8	NaN	NaN	NaN	NaN	0.290469	0.0	902060.436641	737557.236	334577.0	5542.0
cisbp__M4839	Topic8	KLF14, KLF15, SP8, SP9	KLF12, KLF13, KLF16, KLF2, KLF3, KLF5, KLF6, KLF9, PBX3, SP1, SP2, SP3, SP4	KLF17, KLF18	KLF10, KLF11, KLF7, KLF8, SP6, SP7	0.290338	0.000001	872520.090026	713468.902	517022.0	4701.0
jaspar__MA0338.1	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.290284	0.000003	803188.055352	656799.908	505909.0	4809.0
jaspar__MA0443.1	Topic8	NaN	NaN	SP1, SP2, SP3, SP4	KLF15, SP6, SP7, SP8, SP9	0.290204	0.0	823075.246627	673099.756	261260.0	6157.0
hocomoco__E2F4_HUMAN.H11MO.0.A	Topic8	E2F4	E2F1, E2F6, E2F7, TFDP1	NaN	ZNF583	0.290099	0.0	821920.211827	672204.154	559882.0	4469.0
elemento__CGGCGCC	Topic8	NaN	NaN	NaN	NaN	0.29008	0.0	875837.247005	716309.296	251441.0	5967.0
dbcorrdb__GABPA__ENCSR000BIW_1__m2	Topic8	GABPA	BCLAF1, BHLHE40, E2F6, EGR1, ELF1, ELK1, ELK4, ETS1, HCFC1, POLR2A, SIN3A, TAF1	NaN	FLI1	0.289245	0.0	955761.632959	782128.762	258068.0	5987.0
transfac_pro__M00982	Topic8	EGR1, EGR2, EGR3, EGR4	BRF2, CTCF, EZH2, FOS, HDAC2, KLF1, KLF16, KLF3, KLF6, NELFE, NFYB, PATZ1, PBX3, RBBP5, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, ZBTB7B, ZNF148	NaN	WT1, ZBTB17	0.289234	0.000002	808093.741395	661292.452	756690.0	3418.0
dbcorrdb__EZH2__ENCSR000ASZ_1__m2	Topic8	EZH2	MYC, YY1	NaN	NaN	0.289017	0.0	895771.001513	733152.178	442300.0	4921.0
jaspar__MA0079.3	Topic8	SP1, SP2, SP4	EGR1, FOS, IRF1, KLF3, KLF5, KLF6, KLF12, KLF15, KLF16, MAZ, NFYA, NFYB, PATZ1, PBX3, SP3, STAT1, TEAD2, WT1, ZNF281	NaN	E2F4, SP6, SP7, SP8, SP9, ZBTB17	0.288987	0.000002	870771.546589	712706.104	490046.0	4766.0
cisbp__M0254	Topic8	NaN	NaN	NaN	NaN	0.288973	0.0	936148.77569	766223.348	979920.0	3630.0
yetfasco__YML099C_1506	Topic8	NaN	NaN	NaN	NaN	0.288621	0.0	845220.74026	691968.936	475096.0	5127.0
dbcorrdb__EZH2__ENCSR000ASW_1__m2	Topic8	EZH2	NaN	NaN	NaN	0.28835	0.000001	868890.07477	711480.322	358056.0	5313.0
dbcorrdb__CTCF__ENCSR000BHW_1__m2	Topic8	BRF1, BRF2, CEBPB, CTCF, EGR1, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP1, SP2, SP3, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	BHLHE40, CREB1, CUX1, E2F1, E2F6, EGR2, EGR3, EGR4, ELF1, ELK1, ELK4, GABPA, HCFC1, HIC1, IRF1, KAT2A, KLF15, KLF16, KLF3, KLF5, MAX, MYC, NFYB, PATZ1, PBX3, PHF8, POLR3G, RCOR1, REST, SP4, TAF1, TBX15, TFAP2B, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZFX, ZNF148, ZNF263	NaN	ZFY	0.287854	0.0	913422.022444	748201.962	163398.0	6374.0
cisbp__M1709	Topic8	NaN	NaN	NaN	NaN	0.287746	0.000001	828011.192536	678290.962	806475.0	3248.0
scertf__macisaac.STP1	Topic8	NaN	NaN	NaN	NaN	0.28773	0.000001	855233.963939	700599.022	297868.0	5850.0
cisbp__M4291	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.287707	0.000003	802074.035557	657061.66	555406.0	4546.0
elemento__CCGCCGG	Topic8	NaN	NaN	NaN	NaN	0.287249	0.0	887015.077039	726876.056	247292.0	5971.0
yetfasco__YGL013C_485	Topic8	NaN	NaN	NaN	NaN	0.287245	0.0	849711.58719	696309.034	645130.0	4302.0
transfac_pro__M04916	Topic8	EZH2, TAF1	BRF1, MXI1, POLR2A, SMARCA4, ZMIZ1, ZNF274	NaN	NaN	0.287129	0.000002	760810.194175	623507.922	356807.0	5456.0
dbcorrdb__POLR2A__ENCSR000EEM_1__m1	Topic8	POLR2A	ELK1, ELK4, ETV1, GABPA, GABPB1, PML, RELA, SIN3A	NaN	FLI1	0.287044	0.0	935102.261758	766390.622	364289.0	5446.0
cisbp__M6547	Topic8	ZFX	BRF1, BRF2, CTCF, ESRRA, EZH2, MXI1, MYC, POLR2A, RAD21, SMARCA4, SREBF1, SREBF2, XRCC4, ZMIZ1, ZNF274	ZFY	NaN	0.286872	0.000009	850229.513302	696913.938	474991.0	4692.0
cisbp__M1712	Topic8	NaN	NaN	NaN	NaN	0.286859	0.000001	859128.517463	704214.588	774513.0	3763.0
cisbp__M1721	Topic8	NaN	NaN	NaN	NaN	0.286549	0.000002	876587.606985	718680.016	621818.0	4405.0
cisbp__M0005	Topic8	NaN	NaN	NaN	NaN	0.286455	0.0	847734.680242	695069.626	275857.0	5906.0
predrem__nrMotif2235	Topic8	NaN	NaN	NaN	NaN	0.286228	0.000001	929725.235279	762415.126	378627.0	5432.0
cisbp__M3546	Topic8	PATZ1	NaN	NaN	NaN	0.285926	0.000014	854679.893708	701021.24	626534.0	4102.0
cisbp__M1717	Topic8	NaN	NaN	NaN	NaN	0.285653	0.000001	841197.086118	690093.172	873088.0	2988.0
cisbp__M0015	Topic8	NaN	NaN	NaN	NaN	0.285632	0.000005	853203.933552	699953.118	789023.0	3794.0
transfac_pro__M05134	Topic8	NaN	NaN	NaN	NaN	0.285496	0.0	989235.324423	811627.726	157393.0	6514.0
cisbp__M6535	Topic8	EGR1, WT1	CTCF, EGR2, ESRRA, PATZ1, SMARCA4, SP1, SP2, SP3, SP4	NaN	EGR3, EGR4	0.285414	0.000002	798929.553398	655526.772	647618.0	3838.0
hocomoco__KLF6_HUMAN.H11MO.0.A	Topic8	KLF1, KLF6	EGR1, EGR2, EGR3, EGR4, IRF1, KLF2, KLF3, KLF4, KLF5, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, MAZ, NFYA, NFYB, PATZ1, PBX3, PURA, SP1, SP2, SP3, SP4, TBX15	NaN	NaN	0.284903	0.000019	795672.451015	653085.416	825931.0	3163.0
hocomoco__E2F1_MOUSE.H11MO.0.A	Topic8	NaN	E2F4, E2F6, TFDP1	E2F1	NaN	0.284901	0.000003	812831.872147	667170.652	774325.0	3473.0
cisbp__M6325	Topic8	KLF6	NaN	NaN	NaN	0.284889	0.000008	772234.65389	633853.964	945570.0	2650.0
cisbp__M5099	Topic8	NaN	NaN	SMAD1, SMAD5, SMAD9	NaN	0.284732	0.000001	818640.197327	672016.708	644459.0	4058.0
taipale_cyt_meth__KLF4_NRCCMCGCCCN_eDBD	Topic8	KLF2, KLF4, KLF6	KLF11, KLF12, KLF13, KLF14, KLF16, KLF3, KLF5, SP1, SP3, SP8	KLF7	KLF10, KLF8, SP6, SP7, SP9	0.284365	0.000002	824833.711638	677273.322	978334.0	2658.0
dbcorrdb__POLR2A__ENCSR000BHZ_1__m1	Topic8	POLR2A, TAF1	ATF3, GTF2F1, KDM5A, TAF7, THAP1, YY1	NaN	NaN	0.2839	0.0	932972.368932	766313.36	332550.0	5488.0
swissregulon__sacCer__ECM22	Topic8	NaN	NaN	NaN	NaN	0.283751	0.0	967275.911108	794570.996	652613.0	4807.0
jaspar__MA1049.1	Topic8	NaN	NaN	NaN	NaN	0.283687	0.0	881137.203127	723844.568	342018.0	5509.0
transfac_pro__M01916	Topic8	NaN	NaN	NaN	NaN	0.28354	0.0	857218.023074	704266.708	234184.0	6138.0
elemento__CGCCCCC	Topic8	NaN	MAZ	NaN	NaN	0.283348	0.0	822298.931534	675668.226	466587.0	4765.0
predrem__nrMotif220	Topic8	NaN	CTCF, ESRRA, EZH2, MXI1, POLR2A, RAD21, SMARCA4, SREBF1, XRCC4, ZMIZ1	NaN	NaN	0.283326	0.0	908798.137309	746754.432	247389.0	5926.0
cisbp__M0667	Topic8	NaN	NaN	NaN	NaN	0.283185	0.000001	854831.889547	702479.372	422372.0	4875.0
transfac_pro__M01839	Topic8	NaN	NaN	NaN	NaN	0.283168	0.000001	809320.530828	665086.95	864176.0	3234.0
cisbp__M6195	Topic8	E2F6	E2F1, E2F4	NaN	E2F3	0.283051	0.000017	815977.955491	670612.286	823638.0	3332.0
elemento__CCGGGCC	Topic8	NaN	NaN	NaN	NaN	0.283007	0.000002	834575.807086	685917.892	483371.0	4664.0
transfac_pro__M09564	Topic8	NaN	NaN	NaN	NaN	0.282964	0.0	828206.611777	680703.582	337716.0	5447.0
dbcorrdb__SMARCA4__ENCSR000EZC_1__m10	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP2, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	BHLHE40, CREB1, CUX1, E2F1, E2F6, EGR1, EGR2, EGR3, EGR4, ELF1, ELK1, ELK4, ETS1, GABPA, HCFC1, HIC1, IRF1, JUND, KAT2A, KLF16, KLF3, KLF5, MAX, MYC, NFYB, NR2C2, PATZ1, PBX3, PHF8, POLR3G, RCOR1, REST, SIN3A, SP1, SP3, TAF1, TBX15, TRIM28, UBTF, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZFX, ZNF143, ZNF263	NaN	ZBTB17, ZFY	0.282934	0.0	998376.009583	820583.06	103380.0	6806.0
elemento__CCCGCGC	Topic8	NaN	NaN	NaN	NaN	0.282881	0.0	860366.540411	707176.558	327726.0	5499.0
transfac_pro__M07615	Topic8	SP1, SP2, SP3	CTCF, EGR1, EGR2, EGR3, EGR4, EZH2, IRF1, KLF1, KLF12, KLF2, KLF3, KLF5, PAX5, PBX3, POLR2A, SMARCA4, SP4, STAT1	NaN	NaN	0.282867	0.000001	792202.913756	651155.686	510262.0	4538.0
dbcorrdb__E2F4__ENCSR000EWL_1__m1	Topic8	E2F4, E2F6	ELF1, ELK4, ETS1, GABPA, HCFC1, SIN3A, ZNF274	NaN	NaN	0.282702	0.0	929944.16114	764460.432	264746.0	5782.0
swissregulon__sacCer__OAF1	Topic8	NaN	NaN	NaN	NaN	0.282678	0.000001	957826.460598	787394.238	531255.0	4982.0
dbcorrdb__HDAC1__ENCSR000AQF_1__m1	Topic8	HDAC1	MAX, MXI1, MYC, SAP30	NaN	NaN	0.282623	0.000002	943534.369436	775675.134	615550.0	4694.0
predrem__nrMotif2126	Topic8	NaN	NaN	NaN	NaN	0.282558	0.000003	860325.393267	707300.842	584814.0	4192.0
transfac_pro__M05046	Topic8	NaN	NaN	NaN	NaN	0.282304	0.0	978261.1015	804401.296	218860.0	6302.0
elemento__CCCCGGG	Topic8	NaN	NaN	NaN	NaN	0.282239	0.000001	839695.032531	690492.882	402474.0	5269.0
dbcorrdb__TAF1__ENCSR000BHO_1__m1	Topic8	KDM5A, POLR2A, RBBP5, TAF1, TAF7, YY1	ATF3, MYC, PHF8	NaN	TAF1L, YY2	0.282012	0.0	955894.867104	786169.366	292469.0	5821.0
dbcorrdb__TAF1__ENCSR000BIB_1__m1	Topic8	PHF8, TAF1, YY1	EZH2, KDM5A, POLR2A, TAF7, THAP1, ZFP42	NaN	TAF1L	0.281989	0.000001	925781.009078	761414.514	395893.0	5366.0
jaspar__MA0567.1	Topic8	NaN	NaN	NaN	NaN	0.281921	0.000001	852163.124448	700900.188	624823.0	4098.0
elemento__CCCGCGG	Topic8	NaN	NaN	NaN	NaN	0.281919	0.0	878779.881982	722793.062	338934.0	5650.0
transfac_pro__M02281	Topic8	SP1	EGR1, FOS, IRF1, MZF1, NFYB, PATZ1, PBX3, PGAM2, SP2, SP3, SP4, TEAD2, WT1, ZBTB17, ZBTB7B, ZNF148, ZNF281, ZNF444	NaN	SP5	0.281757	0.000006	782548.940613	643715.78	728292.0	3634.0
dbcorrdb__FOS__ENCSR000EYZ_1__m2	Topic8	FOS	NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	NaN	NaN	0.281726	0.000001	910299.258227	748817.888	924408.0	3661.0
dbcorrdb__EZH2__ENCSR000ASZ_1__m3	Topic8	EZH2	NaN	NaN	NaN	0.281652	0.0	905568.434498	744964.396	407628.0	5172.0
cisbp__M0456	Topic8	NaN	KLF1, KLF11, KLF12, KLF13, KLF16, KLF17, KLF2, KLF3, KLF4, KLF5, KLF6, SP1, SP3, SP8, SP9	KLF7	KLF18, KLF8, SP2, SP4, SP6, SP7	0.281627	0.000002	814364.623377	669947.306	913069.0	3033.0
cisbp__M2314	Topic8	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP3	BRF2, CTCF, EGR1, EZH2, KLF12, KLF15, KLF3, KLF5, KLF9, MAZ, PATZ1, SMARCA4, SP4, SREBF1, STAT1, SUPT20H	NaN	E2F4, SP5, SP6, SP7, SP8, SP9, ZBTB17	0.281488	0.000002	824075.172362	678001.15	795869.0	3268.0
cisbp__M1383	Topic8	NaN	NaN	NaN	NaN	0.281387	0.0	957083.450763	787487.986	297180.0	5773.0
predrem__nrMotif2584	Topic8	NaN	NaN	NaN	NaN	0.281252	0.0	960787.795108	790609.586	154017.0	6728.0
dbcorrdb__SUZ12__ENCSR000EXH_1__m4	Topic8	SUZ12	POLR2A	NaN	NaN	0.281249	0.000001	862034.457319	709349.616	537190.0	4406.0
dbcorrdb__POLR2A__ENCSR000EZQ_1__m2	Topic8	POLR2A	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, XRCC4, ZBTB7A, ZMIZ1, ZNF274	NaN	NaN	0.281215	0.0	917590.569033	755083.054	327975.0	5444.0
dbcorrdb__POLR3G__ENCSR000EYU_1__m3	Topic8	BRF1, CEBPB, EZH2, HDAC2, MXI1, NELFE, POLR2A, POLR3G, RBBP5, SREBF1, SREBF2, TRIM28, XRCC4, ZMIZ1, ZNF274	BRF2, CTCF, ESRRA, HCFC1, MAX, MAZ, MYC, RAD21, SMARCA4, SUPT20H, WT1, ZNF460	NaN	ZIC1, ZIC2, ZIC3	0.28119	0.0	875718.350902	720638.936	331217.0	5359.0
cisbp__M1814	Topic8	NaN	NaN	NaN	NaN	0.281092	0.0	877429.580129	722096.38	586012.0	4757.0
transfac_pro__M00920	Topic8	E2F1, E2F3, E2F4, E2F7, TFDP1	E2F5	NaN	NaN	0.281028	0.0	941464.132014	774828.868	391623.0	5530.0
yetfasco__YHR178W_2068	Topic8	NaN	NaN	NaN	NaN	0.280964	0.0	801168.922204	659394.638	402122.0	5421.0
dbcorrdb__ZMIZ1__ENCSR000EFQ_1__m1	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	ATF3, BCLAF1, BHLHE40, CNOT3, CREB1, E2F1, E2F6, EGR1, ELK1, ELK4, ETS1, GABPA, HCFC1, HIC1, JUND, MAX, MAZ, MYC, NR2C2, PHF8, RCOR1, SIN3A, SP1, SP2, SP3, SP4, TAF1, TFAP2A, TFAP2B, TFAP2C, TRIM28, UBTF, ZBTB7A, ZC3H11A, ZEB1, ZFX, ZNF143	NaN	ZFY	0.280903	0.0	968389.885639	797058.276	299221.0	5964.0
factorbook__E2F1	Topic8	E2F1	NaN	NaN	NaN	0.280871	0.000001	868879.864456	715169.508	474872.0	4665.0
transfac_pro__M08878	Topic8	EGR1, EGR2, EGR3, EGR4	CTCF, SMARCA4	NaN	NaN	0.280756	0.000001	796532.062413	655672.804	618394.0	4098.0
dbcorrdb__NFYB__ENCSR000DNM_1__m2	Topic8	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP4	BRF1, BRF2, CTCF, EGR1, EGR2, EGR3, EGR4, EZH2, KLF15, KLF3, KLF5, KLF9, MAZ, RAD21, SMARCA4, SP3, SREBF1, SREBF2, STAT1, XRCC4, ZBTB7A	NaN	E2F4, SP5, SP6, SP7, SP8, SP9	0.280696	0.000001	854959.366789	703797.404	247588.0	6021.0
elemento__CGGCGGC	Topic8	NaN	NaN	NaN	NaN	0.280611	0.0	869868.885386	716112.736	329835.0	5618.0
transfac_pro__M01966	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.280605	0.000004	803252.107427	661274.08	584019.0	4444.0
cisbp__M1728	Topic8	NaN	NaN	NaN	NaN	0.280165	0.0	842568.487706	693852.542	978639.0	2718.0
elemento__CCCCGCG	Topic8	NaN	NaN	NaN	NaN	0.279939	0.0	865282.087505	712668.842	352363.0	5484.0
cisbp__M4413	Topic8	NaN	NaN	NaN	NaN	0.27993	0.000002	904500.883369	744974.902	568561.0	4458.0
flyfactorsurvey__Sp1_SOLEXA_2.5_FBgn0020378	Topic8	KLF9	FOS, IRF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF12, KLF13, KLF14, KLF15, KLF16, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4, STAT1	SP6, SP7, SP8, SP9	E2F4, KLF7, KLF8, KLF10, KLF11, KLF17, KLF18	0.27993	0.000001	848103.57105	698524.45	257584.0	6249.0
transfac_pro__M01068	Topic8	NaN	CPSF4, EGR1, EGR2, SP1, ZBTB17, ZNF148, ZNF281	NaN	NaN	0.27986	0.000024	853579.422519	703068.564	750690.0	3591.0
hocomoco__E2F6_MOUSE.H11MO.0.A	Topic8	NaN	E2F1, E2F4	E2F6	E2F3	0.279857	0.000016	814835.034044	671157.178	764125.0	3595.0
hocomoco__KLF9_HUMAN.H11MO.0.C	Topic8	KLF9, KLF15, KLF16	FOS, IRF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF12, KLF13, KLF14, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4, SP8, SP9	SP6, SP7	KLF7, KLF8, KLF10, KLF11, KLF17, KLF18	0.279424	0.000001	931528.264153	767504.526	366940.0	5398.0
swissregulon__sacCer__PUT3	Topic8	NaN	NaN	NaN	NaN	0.279265	0.000001	845657.912621	696831.412	438153.0	5529.0
dbcorrdb__NR2C2__ENCSR000EVS_1__m1	Topic8	NR2C2	BCLAF1, ELF1, ELF2, ELF5, ELK4, ETV6, ETV7, GABPA, HCFC1, KDM5A, PHF8, POLR2A, SIN3A, TAF1	NaN	NaN	0.278976	0.0	950458.589711	783344.766	378503.0	5635.0
transfac_pro__M05039	Topic8	NaN	NaN	NaN	NaN	0.278858	0.0	979820.358341	807610.522	143329.0	6635.0
cisbp__M1739	Topic8	NaN	NaN	NaN	NaN	0.278805	0.0	856578.470811	706054.702	726049.0	3906.0
cisbp__M2230	Topic8	NaN	NaN	NaN	NaN	0.278598	0.000004	839008.16757	691671.59	701334.0	3903.0
dbcorrdb__POLR2A__ENCSR000EAR_1__m1	Topic8	POLR2A	BCLAF1, BRF1, CREB1, E2F6, ELF1, ELK4, ETS1, EZH2, GABPA, GTF2F1, HCFC1, MAX, MXI1, PHF8, PML, SIN3A, SREBF1, TAF1, ZMIZ1, ZNF274	NaN	NaN	0.278324	0.0	948478.676964	782066.602	258935.0	5845.0
cisbp__M1748	Topic8	NaN	NaN	NaN	NaN	0.278291	0.000001	905862.68579	746944.416	609789.0	4464.0
elemento__CCCCCGC	Topic8	NaN	NaN	NaN	NaN	0.278249	0.000002	815648.58492	672576.466	680097.0	3860.0
cisbp__M6553	Topic8	ZNF219	NaN	NaN	NaN	0.277865	0.000002	851513.695751	702337.688	733337.0	3628.0
elemento__CGCCCGC	Topic8	NaN	NaN	NaN	NaN	0.277792	0.0	876240.717564	722769.262	252291.0	5890.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIC_1__m1	Topic8	NaN	POLR2A, ZNF143	NaN	NaN	0.27773	0.0	922521.450763	760976.798	360968.0	5342.0
hdpi__TRIM69	Topic8	TRIM69	NaN	NaN	NaN	0.277621	0.0	844164.159375	696393.52	846746.0	3519.0
swissregulon__hs__ZFP161.p2	Topic8	ZBTB14	NaN	NaN	NaN	0.276845	0.000002	979525.106166	808494.434	953346.0	3956.0
transfac_pro__M04999	Topic8	NaN	NaN	NaN	NaN	0.276666	0.0	1024959.777834	846100.834	230486.0	6488.0
jaspar__MA0599.1	Topic8	KLF5	IRF1, KLF1, KLF2, KLF3, KLF4, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, SP1, SP2, SP3, SP4	NaN	SP6, SP7, SP8, SP9	0.276641	0.000005	881349.297314	727563.39	658231.0	4161.0
cisbp__M1799	Topic8	NaN	NaN	NaN	NaN	0.276564	0.0	839671.266801	693194.65	916332.0	3192.0
elemento__CGGCCCC	Topic8	NaN	NaN	NaN	NaN	0.276471	0.000001	815337.385702	673149.22	543829.0	4320.0
transfac_pro__M00933	Topic8	SP1, SP2, SP3, SP4	CTCF, EGR1, EGR2, FOS, IRF1, KLF15, KLF16, KLF5, NFYA, NFYB, PATZ1, PBX3, SP9, STAT1, TEAD2, WT1, ZBTB7B, ZNF148, ZNF281	NaN	SP6, SP7, SP8, ZBTB17	0.276458	0.000002	779978.333501	643962.18	362842.0	5389.0
homer__GGCCCCGCCCCC_Sp1	Topic8	IRF1, PBX3, SP1, SP2, SP3, SP4	EGR1, ESRRA, EZH2, FOS, KLF3, KLF5, KLF9, KLF12, KLF14, KLF15, KLF16, NFYA, NFYB, PATZ1, STAT1, TEAD2	NaN	KLF17, KLF18, SP6, SP7, SP8, SP9	0.276452	0.0	921365.140335	760696.536	296830.0	5653.0
cisbp__M4349	Topic8	NaN	NaN	NaN	NaN	0.275946	0.0	916196.981087	756695.036	411080.0	5410.0
dbcorrdb__POLR2A__ENCSR000DLQ_1__m1	Topic8	POLR2A	NaN	NaN	NaN	0.275919	0.000001	919081.896608	759091.832	351403.0	5390.0
cisbp__M0443	Topic8	NaN	KLF1, KLF11, KLF13, KLF14, KLF15, KLF16, KLF17, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, SP1, SP3, SP4, SP8, SP9	KLF12, KLF7, KLF8	KLF10, KLF18, SP2, SP6, SP7	0.275895	0.000002	823489.419241	680151.022	839297.0	3342.0
cisbp__M1763	Topic8	NaN	NaN	NaN	NaN	0.275705	0.000001	944118.60232	779885.716	363757.0	5641.0
dbcorrdb__BRF1__ENCSR000DNW_1__m2	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, TRIM28, XRCC4, ZMIZ1, ZNF274	ATF3, BCLAF1, BHLHE40, CREB1, E2F1, E2F6, EGR1, ELK4, ETS1, GABPA, HCFC1, HIC1, JUND, KAT2A, KLF16, MAX, MYC, NRF1, PHF8, RCOR1, SIN3A, SP1, SP2, SP3, SP4, TAF1, TFAP2B, UBTF, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZFX, ZNF143	NaN	ZFY	0.275522	0.0	955575.516328	789449.77	196963.0	6225.0
jaspar__MA0431.1	Topic8	NaN	NaN	NaN	NaN	0.275466	0.00001	862696.870004	712745.626	533034.0	4501.0
hocomoco__ZBT7A_HUMAN.H11MO.0.A	Topic8	ZBTB7A	NaN	NaN	NaN	0.275417	0.0	844907.281175	698072.17	482862.0	5062.0
dbcorrdb__ELF1__ENCSR000BPT_1__m1	Topic8	BCLAF1, ELF1, ELF2, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, SIN3A	E2F6, EGR1, EHF, ELF3, ELF4, ELF5, ELK1, ELK3, ETV2, ETV6, GABPB1, IRF1, PML, RBBP5, RELA, TAF1	NaN	ERG, FLI1	0.274925	0.0	994009.87303	821542.604	359932.0	6066.0
dbcorrdb__POLR2A__ENCSR000BGD_1__m1	Topic8	POLR2A, TAF1	ATF3, KDM5A, TAF7, YY1	NaN	TAF1L	0.274776	0.0	935721.819317	773447.668	233804.0	6058.0
cisbp__M1821	Topic8	NaN	NaN	NaN	NaN	0.274736	0.0	837311.509646	692123.15	725548.0	3874.0
dbcorrdb__GABPA__ENCSR000BIW_1__m1	Topic8	BCLAF1, ELF1, ELK1, ELK4, ETS1, GABPA, GABPB1, HCFC1, POLR2A, SIN3A, TAF1	BHLHE40, EGR1, ELF2, ELK3, ERG, ETV1, ETV3, ETV4, ETV5, EZH2, FEV, FLI1, MAX, MXI1, MYC, PHF8, PML, RBBP5, REST, SMARCA4, SREBF1, SRF, XRCC4, ZMIZ1, ZNF143	NaN	ERF, ETS2, ETV2, ETV3L, ETV6, ETV7	0.274671	0.0	989064.928004	817599.346	370657.0	5894.0
elemento__CGGCCCG	Topic8	NaN	NaN	NaN	NaN	0.274665	0.0	874502.279662	722900.354	237751.0	6011.0
dbcorrdb__POLR2A__ENCSR000DMN_1__m1	Topic8	POLR2A, TAF1	EZH2, GABPA, MXI1, PHF8	NaN	FLI1	0.274649	0.0	930074.255832	768847.41	329710.0	5501.0
transfac_pro__M05008	Topic8	NaN	NaN	NaN	NaN	0.274531	0.0	1011296.583407	836058.288	488921.0	5637.0
cisbp__M1462	Topic8	NaN	NaN	NaN	NaN	0.274049	0.0	917734.984617	758962.436	406061.0	5534.0
taipale_cyt_meth__KLF16_NCCACRCCCN_eDBD_meth	Topic8	KLF16	KLF10, KLF11, KLF13, KLF14, KLF15, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP3, SP4, SP8, SP9	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP2, SP6, SP7	0.274038	0.0	851203.825873	703946.776	616661.0	4295.0
cisbp__M1793	Topic8	NaN	NaN	NaN	NaN	0.273862	0.0	849411.257345	702550.226	425108.0	5646.0
cisbp__M0392	Topic8	NaN	EGR1, FOS, IRF1, KLF15, KLF16, KLF9, NFYA, SP2, SP3, SP4, SP8, SP9, WT1	SP1	EGR2, EGR3, EGR4, SP6, SP7	0.273816	0.0	868182.871517	718099.15	392256.0	5350.0
flyfactorsurvey__Sp1_SANGER_5_FBgn0020378	Topic8	NaN	IRF1, KLF4, KLF5, KLF9, KLF10, KLF11, KLF13, KLF14, KLF15, KLF16, SP1, SP2, SP3, SP4	SP6, SP7, SP8, SP9	EGR1, KLF6, KLF7, KLF8, KLF12, KLF17, KLF18	0.273788	0.000001	818336.223301	676882.65	224667.0	6462.0
dbcorrdb__NFYA__ENCSR000EGR_1__m2	Topic8	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	EGR1, KLF1, KLF15, KLF3, KLF5, KLF6, KLF9, MAZ, STAT1	NaN	E2F4, SP6, SP7, SP8, SP9	0.273772	0.0	950821.47598	786475.928	322220.0	5704.0
dbcorrdb__TAF1__ENCSR000BQN_1__m1	Topic8	TAF1, YY1	KDM5A, POLR2A, RBBP5, TAF7, THAP1	NaN	NaN	0.273626	0.000001	944944.495776	781693.888	288807.0	5778.0
swissregulon__hs__KLF4.p3	Topic8	KLF4, KLF5	KLF1, KLF2, KLF3, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17, SP1, SP3, SP8, SP9	NaN	KLF18, SP2, SP4, SP6, SP7	0.27334	0.000004	834999.836338	690880.324	621513.0	4135.0
cisbp__M4540	Topic8	ELF1, ELK4, GABPA, HCFC1, PHF8	BCLAF1, EGR1, ELF2, ELF5, ELK1, ELK3, ERF, ERG, ETS1, ETV1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, GABPB1, NR2C2, PML, POLR2A, RELA, SIN3A, SRF, TAF1, ZNF143	NaN	ETS2, ETV3L, ETV6, ETV7	0.273229	0.000001	963132.294666	796958.718	546925.0	5070.0
yetfasco__YDR303C_580	Topic8	NaN	NaN	NaN	NaN	0.273121	0.0	918521.048292	760101.274	216795.0	6187.0
predrem__nrMotif208	Topic8	NaN	POLR2A	NaN	NaN	0.272903	0.0	947697.052452	784364.018	125732.0	6830.0
jaspar__MA1005.1	Topic8	NaN	ATF3, TAF1	NaN	NaN	0.272868	0.0	912866.059639	755554.36	207844.0	6296.0
factorbook__E2F4	Topic8	E2F4, E2F6, SIN3A	NaN	NaN	NaN	0.272852	0.000001	920047.321271	761506.594	330914.0	5631.0
dbcorrdb__PAX5__ENCSR000BJI_1__m1	Topic8	PAX5, PAX8	PAX1, PAX2, PAX6, PAX9	NaN	NaN	0.272691	0.00001	875931.745303	725073.57	647414.0	4026.0
transfac_pro__M01175	Topic8	ZBTB7B	NaN	NaN	NaN	0.272553	0.00001	781458.358719	646933.02	905939.0	2886.0
swissregulon__sacCer__CHA4	Topic8	NaN	NaN	NaN	NaN	0.272367	0.0	899499.563107	744749.574	273628.0	6123.0
cisbp__M0531	Topic8	NaN	NaN	NaN	NaN	0.272326	0.000002	867855.1102	718569.844	347080.0	5542.0
dbcorrdb__EZH2__ENCSR000ARD_1__m6	Topic8	BRF1, BRF2, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, XRCC4, ZNF274	CEBPB, CREB1, CUX1, E2F6, EGR1, EGR2, EGR3, EGR4, FOS, HIC1, IRF1, KAT2A, KLF16, KLF3, MAX, MAZ, MYC, NFYB, RCOR1, SP1, SP2, SP3, SP4, WRNIP1, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZMIZ1, ZNF263, ZNF460	NaN	ZBTB17, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.272299	0.0	943684.172992	781369.388	167504.0	6315.0
dbcorrdb__MAZ__ENCSR000EDN_1__m1	Topic8	CEBPB, MAZ	BRF1, BRF2, CTCF, CUX1, EGR1, EZH2, FOS, HDAC2, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, RCOR1, SMARCA4, SP1, SP2, SP3, SREBF1, SREBF2, SUPT20H, TRIM28, XRCC4, ZBTB7B, ZC3H11A, ZNF274	NaN	NaN	0.271937	0.000006	859830.745429	712117.698	467575.0	4588.0
predrem__nrMotif1839	Topic8	NaN	NaN	NaN	NaN	0.271919	0.000012	913642.319506	756694.184	411882.0	5088.0
transfac_pro__M05022	Topic8	NaN	NaN	NaN	NaN	0.271763	0.000001	993500.635733	822923.342	185521.0	6401.0
jaspar__MA0425.1	Topic8	NaN	NaN	NaN	NaN	0.271608	0.000006	840404.265414	696187.112	696333.0	3916.0
cisbp__M1768	Topic8	NaN	NaN	NaN	NaN	0.271596	0.000001	961945.931661	796878.378	441488.0	5403.0
dbcorrdb__EZH2__ENCSR000ATA_1__m4	Topic8	EZH2	NaN	NaN	NaN	0.271468	0.0	914680.219014	757790.94	258199.0	5918.0
cisbp__M0671	Topic8	E2F2	E2F1, E2F3, E2F4	NaN	E2F6	0.271463	0.000002	878837.994704	728098.664	350321.0	5417.0
hocomoco__MAZ_HUMAN.H11MO.1.A	Topic8	MAZ	KLF5, SP1, VEZF1, WT1	NaN	NaN	0.271202	0.000005	822872.460093	681855.73	540618.0	4530.0
cisbp__M0089	Topic8	NaN	NaN	NaN	NaN	0.271191	0.000001	871788.913756	722394.92	519860.0	4884.0
scertf__badis.YLR278C	Topic8	NaN	NaN	NaN	NaN	0.27113	0.000001	885095.783003	733452.67	329182.0	5963.0
transfac_pro__M07911	Topic8	NaN	KLF13, KLF15, SP8, SP9	SP1, SP2, SP3, SP4	SP6, SP7	0.270945	0.000002	821515.010591	680852.144	812376.0	3534.0
elemento__CGGCCGC	Topic8	NaN	NaN	NaN	NaN	0.270924	0.0	863401.195057	715576.958	235754.0	6036.0
transfac_pro__M03203	Topic8	NaN	NaN	NaN	NaN	0.270734	0.000002	915556.495776	758902.54	581521.0	4681.0
cisbp__M4300	Topic8	NaN	NaN	NaN	NaN	0.27065	0.0	996512.586937	826055.32	274983.0	6207.0
dbcorrdb__GABPA__ENCSR000BJK_1__m1	Topic8	BCLAF1, ELF1, ELK1, ELK4, ETS1, GABPA, GABPB1, HCFC1, PHF8, PML, POLR2A, SIN3A, TAF1	BRF1, CEBPB, CTCF, E2F6, EGR1, ELF2, ELK3, ERF, ERG, ESRRA, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, EZH2, FEV, FLI1, GTF2F1, HDAC2, KDM5B, MAX, MXI1, MYC, NELFE, NR2C2, RAD21, RBBP5, RELA, SMARCA4, SREBF1, SREBF2, UBTF, XRCC4, ZMIZ1, ZNF143	NaN	ETS2, ETV3L, ETV7	0.27055	0.0	992048.950195	822411.712	889680.0	4180.0
dbcorrdb__POLR2A__ENCSR000DLJ_1__m1	Topic8	POLR2A	ATF3	NaN	NaN	0.270283	0.000001	929991.414324	771108.92	344769.0	5451.0
predrem__nrMotif887	Topic8	NaN	NaN	NaN	NaN	0.270144	0.000028	846190.192536	701692.086	507195.0	4664.0
predrem__nrMotif2571	Topic8	NaN	NaN	NaN	NaN	0.27003	0.000001	930671.362502	771807.708	407022.0	5284.0
cisbp__M1787	Topic8	NaN	NaN	NaN	NaN	0.269927	0.0	891306.435002	739215.012	560475.0	4674.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIA_1__m1	Topic8	BCLAF1, ELF1, ETS1, GABPA, HCFC1, PHF8, POLR2A, SIN3A	ELF2, ELK1, ELK4, ETV6, GABPB1, IRF1, KDM5B, PML, RBBP5, RELA, SRF, TAF1, ZNF143	NaN	ERG, FLI1	0.269887	0.000001	960094.530072	796287.338	305850.0	5775.0
cisbp__M0383	Topic8	NaN	EGR1, EGR3, EGR4	NaN	EGR2	0.269706	0.000005	839715.725129	696534.576	476470.0	4952.0
dbcorrdb__HMGN3__ENCSR000DOB_1__m2	Topic8	HMGN3	NaN	NaN	NaN	0.269551	0.000014	822881.389989	682644.246	355816.0	5351.0
elemento__CGCGCCC	Topic8	NaN	NaN	NaN	NaN	0.269546	0.0	878039.298953	728404.206	240464.0	5998.0
transfac_pro__M07063	Topic8	SP1, SP3	CTCF, FOS, IRF1, KLF12, KLF3, KLF5, KLF6, NFYA, NFYB, PBX3, SP2, SP4, STAT1	NaN	NaN	0.269472	0.000002	781225.999622	648123.04	322377.0	5641.0
jaspar__MA0516.1	Topic8	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP3	BRF2, CTCF, EGR1, EZH2, KLF3, KLF5, KLF9, KLF12, KLF15, MAZ, PATZ1, SMARCA4, SP4, SREBF1, STAT1, SUPT20H	NaN	E2F4, SP5, SP6, SP7, SP8, SP9, ZBTB17	0.269337	0.000006	848706.087126	704172.094	680762.0	3790.0
cisbp__M0405	Topic8	NaN	KLF10, KLF1, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, SP1, SP3, SP4, SP8, SP9	KLF7, KLF8	KLF18, SP2, SP6, SP7	0.269327	0.000005	810251.890178	672271.34	790886.0	3546.0
swissregulon__sacCer__RSC3	Topic8	NaN	NaN	NaN	NaN	0.269146	0.0	966576.355062	802075.584	204577.0	6193.0
dbcorrdb__EGR1__ENCSR000BJA_1__m1	Topic8	BRF1, EGR1, EGR2, HDAC2, NELFE, SP1, WT1, XRCC4	BRF2, CEBPB, CTCF, CUX1, E2F6, EGR3, EGR4, ELK4, ESRRA, EZH2, FOS, GABPA, IRF1, KLF1, KLF15, KLF16, KLF3, KLF5, KLF6, MAX, MAZ, MXI1, PATZ1, PAX5, PBX3, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TBX15, TEAD2, VEZF1, ZBTB7B, ZMIZ1, ZNF274, ZNF467	NaN	SP5, ZBTB17, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.268994	0.000004	897278.048292	744649.444	414829.0	5024.0
dbcorrdb__NR2C2__ENCSR000EUL_1__m1	Topic8	NR2C2	BRF1, BRF2, ESRRA, EZH2, MXI1, POLR2A, SMARCA4, SREBF1, SREBF2, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.268979	0.000001	862265.718194	715600.148	273210.0	6010.0
jaspar__MA0123.1	Topic8	NaN	NaN	NaN	NaN	0.268553	0.000015	778164.868995	645995.11	266615.0	5982.0
taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	Topic8	ZBTB37	NaN	NaN	NaN	0.268462	0.000001	961949.007313	798614.004	685648.0	4617.0
dbcorrdb__POLR2A__ENCSR000EBK_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, RBBP5, SIN3A, ZNF143	BHLHE40, CTCF, E2F6, ELK1, EZH2, FOXP2, GABPB1, KDM5B, MAX, MXI1, MYC, PML, SRF, TAF1, THAP1, XRCC4	NaN	ERG, FLI1	0.268444	0.0	949146.829278	787995.61	325247.0	5678.0
dbcorrdb__RXRA__ENCSR000BJD_1__m6	Topic8	RXRA	CTCF, CTCFL, RAD21, SMC3, ZBTB7A	NaN	NaN	0.268281	0.000136	826696.945026	686413.296	624617.0	4064.0
transfac_public__M00263	Topic8	NaN	NaN	NaN	NaN	0.268003	0.000009	934481.907326	776057.628	1082757.0	3268.0
dbcorrdb__EZH2__ENCSR000ARR_1__m4	Topic8	EZH2	NaN	NaN	NaN	0.267918	0.0	927476.207666	770284.752	231950.0	6126.0
dbcorrdb__E2F4__ENCSR000EVL_1__m1	Topic8	E2F4, E2F6, SIN3A	TFDP1	NaN	NaN	0.267905	0.000001	939606.649351	780366.718	298911.0	5811.0
dbcorrdb__POLR2A__ENCSR000DPA_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, PML, POLR2A, SIN3A	EGR1, ELF2, ELF5, ELK1, ELK3, ERG, ETV1, ETV2, ETV4, ETV5, ETV6, FEV, FLI1, FOXP2, GABPB1, IRF1, KDM5B, RBBP5, RELA, SRF, TAF1, THAP1, ZNF143	NaN	NaN	0.267847	0.000001	955873.76699	793908.466	339923.0	5625.0
swissregulon__hs__TFAP2_A_C_.p2	Topic8	TFAP2A, TFAP2C	TFAP2B	NaN	NaN	0.267827	0.000005	826398.956626	686382.086	533623.0	4592.0
dbcorrdb__EZH2__ENCSR000ARK_1__m3	Topic8	EZH2	NaN	NaN	NaN	0.267525	0.000007	862902.082587	716850.048	591505.0	4434.0
hocomoco__MBD2_HUMAN.H11MO.0.B	Topic8	MBD2	NaN	NaN	NaN	0.267461	0.0	926932.759803	770077.436	210265.0	6321.0
dbcorrdb__TAF1__ENCSR000BQF_1__m1	Topic8	RBBP5, TAF1, YY1	ATF3, BCLAF1, ELK4, ETS1, GABPA, HCFC1, KDM5A, MYC, POLR2A, SIN3A, TAF7	NaN	TAF1L	0.267311	0.000001	957375.593872	795451.638	297383.0	5750.0
cisbp__M0616	Topic8	NaN	NaN	NaN	NaN	0.267249	0.0	817933.405119	679623.034	280184.0	6309.0
cisbp__M2247	Topic8	NaN	NaN	SP1, SP2, SP3, SP4	KLF15, SP6, SP7, SP8, SP9	0.267007	0.000001	859894.922708	714608.41	235738.0	6263.0
predrem__nrMotif243	Topic8	NaN	NaN	NaN	NaN	0.266934	0.000015	866645.209936	720255.076	494392.0	4685.0
dbcorrdb__TAF1__ENCSR000BHO_1__m2	Topic8	TAF1	NaN	NaN	NaN	0.26691	0.000002	905909.641533	752899.404	445808.0	4997.0
dbcorrdb__POLR2A__ENCSR000DLV_1__m1	Topic8	POLR2A	ATF3, EZH2, MYC	NaN	NaN	0.266803	0.0	960551.771025	798371.642	218292.0	6159.0
flyfactorsurvey__CG1621_SANGER_5_FBgn0033182	Topic8	NaN	NaN	NaN	NaN	0.266661	0.000002	896308.199723	745048.37	645392.0	4608.0
dbcorrdb__POLR2A__ENCSR000EAY_1__m1	Topic8	ELK4, GABPA, PML, POLR2A, TAF1	BCLAF1, BRF1, E2F1, E2F6, ELF1, ELK1, ETS1, ETV1, EZH2, GABPB1, GTF2F1, HCFC1, MAX, MXI1, NR2C2, PHF8, SIN3A, SMARCA4, XRCC4, ZMIZ1, ZNF274	NaN	ERG, FLI1	0.266526	0.000001	947308.579624	787515.678	167688.0	6573.0
transfac_pro__M05054	Topic8	NaN	NaN	NaN	NaN	0.266506	0.0	1037510.529946	862514.296	114516.0	7025.0
transfac_pro__M01928	Topic8	NaN	NaN	NaN	NaN	0.266411	0.0	954970.670659	793948.338	325880.0	5634.0
cisbp__M4460	Topic8	ELF1, ELF2, ELK4	BCLAF1, EGR1, EHF, ELF3, ELF4, ELF5, ELK1, ELK3, ETS1, ETV6, GABPA, GABPB1, HCFC1, NR2C2, PHF8, PML, POLR2A, SIN3A, TAF1	NaN	ERF, ETV3, ETV3L, FLI1	0.266405	0.0	961068.234649	799021.516	515819.0	5212.0
dbcorrdb__POLR2A__ENCSR000FAW_1__m2	Topic8	POLR2A	PHF8, TAF1	NaN	NaN	0.266313	0.000001	931376.894465	774385.822	361867.0	5417.0
cisbp__M0402	Topic8	NaN	E2F1, FOS, IRF1, KLF13, KLF14, KLF15, KLF9, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP8, SP9, STAT1, TFDP1	SP4, SP6, SP7	E2F4, KLF17, KLF18	0.266296	0.000005	803476.9855	668052.078	720321.0	3860.0
dbcorrdb__HA-E2F1__ENCSR000EWX_1__m1	Topic8	E2F1	E2F6	NaN	NaN	0.266261	0.000003	955116.341823	794152.202	191360.0	6213.0
cisbp__M0665	Topic8	NaN	E2F1, E2F2	NaN	NaN	0.266146	0.000003	897482.829025	746290.828	380971.0	5218.0
transfac_pro__M05135	Topic8	NaN	NaN	NaN	NaN	0.266046	0.000001	1005246.840499	835958.74	268972.0	6344.0
jaspar__MA0430.1	Topic8	NaN	NaN	NaN	NaN	0.266013	0.000001	930916.323541	774163.568	409601.0	5418.0
cisbp__M4294	Topic8	NaN	NaN	NaN	NaN	0.26583	0.000008	844757.74316	702602.02	666443.0	4028.0
taipale__TFAP2A_DBD_NSCCNNNGGSN	Topic8	TFAP2A, TFAP2B, TFAP2C	TFAP2E	NaN	TFAP2D	0.265688	0.000053	863740.355693	718460.954	813726.0	3332.0
predrem__nrMotif1817	Topic8	NaN	NaN	NaN	NaN	0.265599	0.000002	950525.0812	790697.432	265960.0	6022.0
dbcorrdb__POLR2A__ENCSR000EXO_1__m1	Topic8	POLR2A	ELF1, ETS1, GABPA, HCFC1, MXI1, PHF8, PML, TAF1	NaN	NaN	0.265514	0.000002	929887.958391	773575.988	355061.0	5477.0
predrem__nrMotif2398	Topic8	NaN	NaN	NaN	NaN	0.265503	0.000022	868486.491615	722501.518	519175.0	4562.0
scertf__foat.SKN7	Topic8	NaN	NaN	NaN	NaN	0.265437	0.000009	839027.646325	698026.43	834682.0	3399.0
predrem__nrMotif1899	Topic8	NaN	NaN	NaN	NaN	0.265396	0.000005	899929.033791	748714.336	331125.0	5547.0
dbcorrdb__KDM5B__ENCSR000AQA_1__m2	Topic8	KDM5B	KDM5A, TAF1, YY1	NaN	NaN	0.26535	0.000001	964818.626024	802726.186	202681.0	6273.0
flyfactorsurvey__CG5669_SOLEXA_5_FBgn0039169	Topic8	NaN	FOS, IRF1, KLF3, KLF4, KLF5, KLF9, KLF12, KLF13, KLF14, KLF15, KLF16, NFYA, NFYB, PBX3, SP8, SP9, STAT1	SP1, SP2, SP3, SP4	E2F4, KLF6, KLF7, KLF8, KLF10, KLF11, KLF17, KLF18, SP6, SP7	0.265091	0.000001	908256.859665	755802.314	325105.0	5805.0
cisbp__M0056	Topic8	NaN	NaN	NaN	NaN	0.265006	0.000007	848197.808221	705866.238	352097.0	5572.0
transfac_pro__M02744	Topic8	NaN	EGR2, EGR3, EGR4	EGR1	SP4, WT1	0.264923	0.000022	888807.224814	739703.518	563882.0	4382.0
tfdimers__MD00483	Topic8	ZBTB14	NaN	NaN	NaN	0.264853	0.000001	888346.95713	739356.584	267780.0	5797.0
predrem__nrMotif1533	Topic8	NaN	NaN	NaN	NaN	0.264848	0.000004	893921.523515	743998.774	448022.0	5023.0
dbcorrdb__TAF1__ENCSR000BPF_1__m3	Topic8	TAF1	NaN	NaN	NaN	0.264757	0.000002	938198.872021	780899.466	369076.0	5436.0
dbcorrdb__MAZ__ENCSR000EFX_1__m1	Topic8	CTCF, CTCFL, MAZ, RAD21, RXRA, SMC3, ZNF143	ATF3, BRF1, ELK4, HDAC2, MAX, MYC, NELFE, POLR2A, SREBF1, SREBF2, STAT1, TFAP2B, XRCC4, ZBTB7A, ZC3H11A, ZNF274	NaN	REST, ZFP64	0.264751	0.000005	823439.818182	685383.836	485772.0	4521.0
cisbp__M6192	Topic8	E2F3	E2F1, E2F4, E2F5, E2F7, TFDP1	NaN	EVX1, EVX2	0.264648	0.000002	932070.633842	775857.26	369689.0	5512.0
cisbp__M6198	Topic8	EGR1	EGR2, EGR3, EGR4, WT1	NaN	SP4	0.264401	0.000005	852968.306897	710133.922	655736.0	3911.0
dbcorrdb__POLR2A__ENCSR000EYW_1__m1	Topic8	POLR2A	TAF1, YY1	NaN	NaN	0.264376	0.000001	925082.722481	770185.82	229333.0	6128.0
dbcorrdb__EZH2__ENCSR000ARK_1__m1	Topic8	EZH2	NaN	NaN	NaN	0.264363	0.000001	913597.916152	760630.804	241552.0	6207.0
cisbp__M4325	Topic8	NaN	NaN	NaN	NaN	0.264303	0.000007	837824.737864	697573.576	716537.0	3849.0
elemento__CGCGGCC	Topic8	NaN	NaN	NaN	NaN	0.264282	0.0	870515.105787	724802.084	382095.0	5347.0
cisbp__M4462	Topic8	ELK1, ELK4, GABPA, GABPB1, TAF1	BCLAF1, EGR1, ELF1, ELF2, ELF4, ELK3, EP300, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, HCFC1, PHF8, PML, POLR2A, SIN3A, SRF	NaN	ETV3L, ETV7	0.264174	0.000001	969648.174505	807402.348	644859.0	4824.0
cisbp__M4782	Topic8	NaN	NaN	SP1, SP2, SP3, SP4	NaN	0.264172	0.000001	860539.71996	716551.212	339891.0	5650.0
scertf__morozov.PUT3	Topic8	NaN	NaN	NaN	NaN	0.263852	0.000005	833003.89913	693776.726	431965.0	5366.0
taipale_cyt_meth__KLF15_NCCACGCCCMYN_eDBD	Topic8	KLF13, KLF14, KLF15, KLF16, SP3, SP8, SP9	KLF11, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP2, SP4	NaN	KLF10, KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.26385	0.000005	809724.282562	674388.776	658313.0	4038.0
dbcorrdb__TBP__ENCSR000EHA_1__m1	Topic8	TBP	NaN	NaN	NaN	0.263765	0.000005	914477.173875	761678.366	430028.0	5107.0
cisbp__M5209	Topic8	NaN	IRF1, KLF10, KLF11, KLF13, KLF14, KLF15, KLF16, KLF4, KLF5, KLF9, SP1, SP2, SP3, SP4	SP6, SP7, SP8, SP9	EGR1, KLF12, KLF17, KLF18, KLF6, KLF7, KLF8	0.263715	0.000001	849562.076283	707634.674	261997.0	6203.0
predrem__nrMotif251	Topic8	NaN	MAZ	NaN	NaN	0.263492	0.000002	881779.679738	734583.156	357112.0	5364.0
predrem__nrMotif604	Topic8	NaN	NaN	NaN	NaN	0.263469	0.000003	889767.856765	741249.764	398322.0	5239.0
jaspar__MA0535.1	Topic8	NaN	NaN	SMAD1, SMAD5, SMAD9	NaN	0.263387	0.000001	952314.439415	793401.646	228937.0	6168.0
jaspar__MA0374.1	Topic8	NaN	NaN	NaN	NaN	0.26328	0.0	910173.210062	758348.448	216248.0	6192.0
flyfactorsurvey__Mad_FlyReg_FBgn0011648	Topic8	NaN	NaN	SMAD1, SMAD5, SMAD9	NaN	0.263267	0.000005	813575.119405	677870.184	856562.0	3253.0
cisbp__M6324	Topic8	KLF4, KLF5	KLF1, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17, KLF2, KLF3, KLF6, KLF7, KLF8, KLF9, SP1, SP2, SP3, SP4, SP8, SP9	NaN	KLF18, SP6, SP7	0.263233	0.000014	812466.594629	676962.17	836190.0	3248.0
dbcorrdb__E2F1__ENCSR000EVJ_1__m1	Topic8	E2F1	BRF1, E2F6, ESRRA, EZH2, MAX, MXI1, POLR2A, SREBF1, XRCC4, ZNF274	NaN	NaN	0.262982	0.000001	995499.041105	829612.556	116048.0	6745.0
yetfasco__YKL015W_2065	Topic8	NaN	NaN	NaN	NaN	0.262809	0.000006	832484.551002	693845.378	718408.0	3838.0
scertf__badis.RSF2	Topic8	NaN	NaN	NaN	NaN	0.262796	0.000007	804109.723868	670202.17	668973.0	4092.0
dbcorrdb__TAF1__ENCSR000BKS_1__m2	Topic8	BCLAF1, ELF1, ETS1, GABPA, HCFC1, PHF8, POLR2A, SIN3A, TAF1	ELK1, ELK4, ETV6, EZH2, GABPB1, GTF2F1, MXI1, PML, RBBP5	NaN	FLI1	0.262716	0.000002	950269.318875	792065.904	248516.0	6035.0
elemento__CGCAGGCGC	Topic8	NaN	NRF1	NaN	NaN	0.262689	0.000011	898777.785273	749160.628	731243.0	4092.0
transfac_pro__M04989	Topic8	NaN	NaN	NaN	NaN	0.262634	0.000001	981246.154079	817931.996	161260.0	6502.0
cisbp__M1818	Topic8	NaN	NaN	NaN	NaN	0.262617	0.000002	874955.463876	729340.296	877866.0	3505.0
cisbp__M1809	Topic8	NaN	NaN	NaN	NaN	0.262573	0.0	860598.18497	717394.656	522136.0	5265.0
transfac_pro__M04893	Topic8	TAF1	NaN	NaN	NaN	0.262557	0.000003	845526.360736	704838.554	759877.0	4030.0
cisbp__M2090	Topic8	NaN	NaN	ZNF112, ZNF155, ZNF214, ZNF221, ZNF222, ZNF223, ZNF224, ZNF226, ZNF227, ZNF230, ZNF233, ZNF234, ZNF235, ZNF239, ZNF284, ZNF285, ZNF664	NaN	0.26246	0.000012	811048.744168	676143.148	777999.0	3681.0
cisbp__M2199	Topic8	NaN	NaN	NaN	NaN	0.262146	0.000001	895212.354054	746469.614	206407.0	6359.0
cisbp__M1971	Topic8	EGR1, EGR2, WT1	CTCF, EGR3, EGR4, IRF1, KLF16, KLF6, MAZ, PATZ1, SP1, SP2, SP3, SP4, TEAD2	NaN	NaN	0.261969	0.000017	839817.438406	700364.718	621048.0	4091.0
cisbp__M4829	Topic8	NaN	NaN	NaN	NaN	0.261624	0.000003	923935.219014	770698.91	544218.0	4809.0
dbcorrdb__ELK1__ENCSR000EFU_1__m2	Topic8	ELK1	BCLAF1, EGR1, ELF1, ELK4, ETS1, GABPA, GABPB1, HCFC1, MXI1, PHF8, POLR2A, SIN3A, TAF1	NaN	NaN	0.261584	0.000003	901108.889926	751679.396	611716.0	4364.0
dbcorrdb__POLR2A__ENCSR000DNF_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.261392	0.000002	904726.666751	754797.556	313310.0	5575.0
elemento__CTCCGCG	Topic8	NaN	NaN	NaN	NaN	0.261366	0.000001	906537.975413	756322.274	272260.0	5870.0
transfac_pro__M04918	Topic8	EGR1	NaN	NaN	NaN	0.261333	0.000006	897070.97163	748441.046	561716.0	4497.0
elemento__GCCGCCC	Topic8	NaN	NaN	NaN	NaN	0.261293	0.000007	823391.249779	686988.33	628465.0	4055.0
cisbp__M4459	Topic8	CTCF, EGR1, HDAC2	BRF1, BRF2, CEBPB, CUX1, E2F6, EGR2, EGR3, EGR4, ESRRA, EZH2, KLF16, KLF3, MAZ, MXI1, NELFE, PATZ1, PBX3, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TEAD2, WT1, XRCC4, ZBTB7B, ZMIZ1, ZNF467	NaN	ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.261246	0.000007	925256.130374	772003.414	292931.0	5768.0
neph__UW.Motif.0009	Topic8	NaN	MAZ, MZF1, PATZ1, ZBTB17, ZNF148, ZNF281, ZNF444, ZNF467	NaN	PLAGL1	0.261218	0.000016	800831.61619	668200.414	952768.0	2688.0
dbcorrdb__SUZ12__ENCSR000EXH_1__m1	Topic8	SUZ12	NaN	NaN	NaN	0.261181	0.00006	849302.504854	708662.006	625228.0	3952.0
yetfasco__YNL027W_516	Topic8	NaN	NaN	ZNF112, ZNF155, ZNF214, ZNF221, ZNF222, ZNF223, ZNF224, ZNF226, ZNF227, ZNF230, ZNF233, ZNF234, ZNF235, ZNF239, ZNF284, ZNF285, ZNF664	NaN	0.261106	0.000015	809900.558694	675819.684	992896.0	2686.0
cisbp__M1708	Topic8	NaN	NaN	NaN	NaN	0.261065	0.000002	948907.739251	791836.466	406896.0	5409.0
cisbp__M1805	Topic8	NaN	NaN	NaN	NaN	0.260978	0.000003	839925.800277	700936.564	964301.0	2631.0
transfac_pro__M01646	Topic8	NaN	NaN	ZNF112, ZNF155, ZNF214, ZNF221, ZNF222, ZNF223, ZNF224, ZNF226, ZNF227, ZNF230, ZNF233, ZNF234, ZNF235, ZNF239, ZNF284, ZNF285, ZNF664	NaN	0.260695	0.000014	811386.989787	677252.942	775239.0	3689.0
transfac_pro__M04991	Topic8	NaN	NaN	NaN	NaN	0.260647	0.0	1024693.331232	855325.556	334420.0	6244.0
jaspar__MA0285.1	Topic8	NaN	NaN	ZNF112, ZNF155, ZNF214, ZNF221, ZNF222, ZNF223, ZNF224, ZNF226, ZNF227, ZNF230, ZNF233, ZNF234, ZNF235, ZNF239, ZNF284, ZNF285, ZNF664	NaN	0.260542	0.000014	810742.684655	676787.212	775675.0	3687.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIF_1__m2	Topic8	NaN	NaN	NaN	NaN	0.260528	0.000001	930313.493002	776609.546	222780.0	6280.0
dbcorrdb__HCFC1__ENCSR000ECH_1__m3	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, RBBP5, SIN3A, TAF1	E2F4, E2F6, EGR1, ELF2, ELK1, ESRRA, ETV1, ETV6, EZH2, FOXP2, GABPB1, KDM5A, MAX, MXI1, MYC, NR2C2, PML, RELA, SMARCA4, SREBF1, XRCC4, ZMIZ1, ZNF143, ZNF274	NaN	ERG, FLI1	0.260492	0.000001	1022591.122809	853662.608	502622.0	5637.0
transfac_pro__M03213	Topic8	NaN	NaN	NaN	NaN	0.260475	0.0	950226.903417	793261.882	184535.0	6417.0
cisbp__M1871	Topic8	KLF5	KLF10, KLF1, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17, KLF2, KLF3, KLF6, KLF7, KLF8, KLF9, SP1, SP3, SP8, SP9	KLF4	KLF18, SP2, SP4, SP6, SP7	0.260241	0.00001	821529.882108	685935.322	551648.0	4539.0
swissregulon__sacCer__YLR278C	Topic8	NaN	NaN	NaN	NaN	0.259978	0.000001	940017.092926	785008.954	467725.0	5123.0
predrem__nrMotif258	Topic8	NaN	NaN	NaN	NaN	0.259941	0.000002	958252.80696	800258.028	107414.0	6971.0
swissregulon__sacCer__CRZ1	Topic8	NaN	NaN	ZNF112, ZNF155, ZNF214, ZNF221, ZNF222, ZNF223, ZNF224, ZNF226, ZNF227, ZNF230, ZNF233, ZNF234, ZNF235, ZNF239, ZNF284, ZNF285, ZNF664	NaN	0.259903	0.00002	812319.480393	678403.99	697123.0	3899.0
predrem__nrMotif171	Topic8	NaN	NaN	NaN	NaN	0.259862	0.000007	894834.229731	747336.568	365663.0	5466.0
transfac_pro__M05049	Topic8	NaN	NaN	NaN	NaN	0.259779	0.000002	1001788.229984	836709.228	166766.0	6566.0
transfac_pro__M05432	Topic8	ZSCAN18	NaN	NaN	NaN	0.259768	0.000002	946665.423276	790676.1	499633.0	5046.0
cisbp__M1743	Topic8	NaN	NaN	NaN	NaN	0.25976	0.000007	901624.552768	753061.062	876610.0	3492.0
jaspar__MA0339.1	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.259688	0.000017	801806.124322	669723.576	691791.0	3952.0
elemento__CGCCCCG	Topic8	NaN	NaN	NaN	NaN	0.259547	0.0	865777.269575	723227.3	300976.0	5614.0
predrem__nrMotif2242	Topic8	NaN	NaN	NaN	NaN	0.259514	0.000001	951190.91363	794595.806	201196.0	6335.0
dbcorrdb__GABPA__ENCSR000BPY_1__m1	Topic8	ELF1, ELK1, ELK4, GABPA, GABPB1, POLR2A	BCLAF1, BHLHE40, CTCF, EGR1, ELF2, ELK3, ERF, ERG, ESRRA, ETS1, ETV1, ETV2, ETV3, ETV4, ETV5, EZH2, FEV, FLI1, HCFC1, MAX, MXI1, MYC, PHF8, PML, SIN3A, SRF, TAF1, XRCC4, YY1, ZNF143	NaN	ETS2, ETV3L, ETV6, ETV7	0.2595	0.000001	978075.876813	817062.67	828586.0	4228.0
transfac_pro__M08819	Topic8	KLF2	NaN	NaN	NaN	0.259392	0.000024	788431.32228	658686.888	718856.0	3755.0
transfac_pro__M03553	Topic8	KLF3	KLF4	NaN	NaN	0.259326	0.000092	794038.759677	663402.064	925724.0	2836.0
dbcorrdb__RBBP5__ENCSR000AQC_1__m2	Topic8	RBBP5	NaN	NaN	NaN	0.259144	0.000002	905095.518472	756282.82	148351.0	6697.0
taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	Topic8	ZNF281	SP1, SP4	NaN	NaN	0.259099	0.000084	813496.820704	679765.664	746762.0	3670.0
dbcorrdb__ZMIZ1__ENCSR000EFQ_1__m2	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	BCLAF1, BHLHE40, CNOT3, CREB1, E2F1, E2F6, EGR1, ELK1, ELK4, ETS1, GABPA, HCFC1, HIC1, JUND, MAX, MAZ, MYC, NR2C2, PHF8, SIN3A, SP1, SP2, SP4, TAF1, TFAP2B, TRIM28, UBTF, ZBTB7A, ZC3H11A, ZFX	NaN	ZFY	0.258829	0.000001	960422.183836	802688.238	116871.0	6730.0
dbcorrdb__NELFE__ENCSR000DOF_1__m4	Topic8	NELFE	NaN	NaN	NaN	0.25865	0.000073	847934.589837	708762.876	825078.0	3226.0
predrem__nrMotif1115	Topic8	NaN	NaN	NaN	NaN	0.258551	0.000003	925037.289245	773263.586	333446.0	5869.0
cisbp__M0603	Topic8	NaN	NaN	NaN	NaN	0.258463	0.000006	833377.766738	696685.304	1101031.0	2163.0
transfac_pro__M07310	Topic8	SP5	NaN	NaN	NaN	0.258456	0.000002	812171.752868	678961.146	281130.0	5939.0
transfac_pro__M04823	Topic8	E2F1, E2F4	E2F6, E2F7, TFDP1	NaN	NaN	0.258232	0.000014	854066.477619	714095.1	743251.0	3574.0
dbcorrdb__MAZ__ENCSR000EFF_1__m1	Topic8	BRF1, BRF2, CEBPB, CTCF, CUX1, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP3, SREBF1, SREBF2, SUPT20H, TBX15, XRCC4	E2F6, EGR1, EGR4, ESRRA, EZH2, KAT2A, KLF15, KLF16, KLF3, PATZ1, PBX3, POLR3G, RREB1, SP1, SP2, SP4, VEZF1, WT1, ZBTB7B, ZMIZ1, ZNF148, ZNF263, ZNF274, ZNF341, ZNF460, ZNF467	NaN	SP5, ZBTB17, ZNF16, ZNF189, ZNF23, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.258098	0.000005	927182.895473	775300.51	511177.0	5002.0
predrem__nrMotif1871	Topic8	NaN	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP2, SP4, SREBF1, SREBF2, SUPT20H, XRCC4	NaN	NaN	0.258024	0.000003	922652.0319	771551.62	338842.0	5479.0
jaspar__MA0344.1	Topic8	NaN	NaN	NaN	NaN	0.257903	0.000002	870801.992813	728254.134	347969.0	5619.0
predrem__nrMotif1814	Topic8	NaN	NaN	NaN	NaN	0.25786	0.000002	971576.467785	812556.074	213602.0	6362.0
elemento__GCCCGCC	Topic8	NaN	NaN	NaN	NaN	0.25786	0.000003	842277.413315	704419.894	461833.0	4798.0
cisbp__M0022	Topic8	NaN	NaN	NaN	TAF1, TAF1L	0.257829	0.0	842794.506367	704867.532	295406.0	5686.0
cisbp__M1790	Topic8	NaN	NaN	NaN	NaN	0.257824	0.000006	812348.00353	679405.956	932418.0	2800.0
swissregulon__sacCer__ZMS1	Topic8	NaN	NaN	NaN	NaN	0.257709	0.00006	836237.376371	699441.786	847604.0	3284.0
dbcorrdb__TAF1__ENCSR000BHT_1__m1	Topic8	RBBP5, TAF1, YY1	ATF3, BCLAF1, GABPA, KDM5A, POLR2A, SIN3A, TAF7	NaN	TAF1L	0.257681	0.000001	941542.741395	787536.046	266858.0	5989.0
elemento__CCGGCCG	Topic8	NaN	NaN	NaN	NaN	0.257547	0.000001	878491.175009	734865.696	224384.0	6129.0
cisbp__M1813	Topic8	NaN	NaN	NaN	NaN	0.257364	0.000002	849611.953222	710798.456	563598.0	4855.0
elemento__AGGGGCG	Topic8	NaN	NaN	NaN	NaN	0.257321	0.000002	862063.09154	721236.668	525154.0	4583.0
scertf__zhu.YLL054C	Topic8	NaN	NaN	NaN	NaN	0.25729	0.000003	947876.148909	793048.396	379250.0	5526.0
transfac_pro__M07460	Topic8	KLF3	KLF10, KLF1, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, KLF2, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, ZNF148	NaN	NaN	0.257246	0.000185	783970.576346	655935.42	896563.0	2900.0
cisbp__M4563	Topic8	ELF1, ELF2	BCLAF1, EGR1, EHF, ELF3, ELF4, ELF5, ELK1, ELK3, ELK4, ETV6, GABPA, GABPB1, HCFC1, PHF8, POLR2A, SIN3A	NaN	ERF, ETS1, ETV3, ETV3L, FLI1	0.257235	0.000001	956474.152818	800272.504	657737.0	4621.0
predrem__nrMotif429	Topic8	NaN	NaN	NaN	NaN	0.257198	0.000013	896405.09734	750032.434	437350.0	5071.0
transfac_pro__M03200	Topic8	NaN	NaN	NaN	NaN	0.257084	0.000007	924462.321901	773569.43	322136.0	5675.0
transfac_pro__M07380	Topic8	E2F4	NaN	NaN	NaN	0.256626	0.000003	849590.864204	711144.204	591699.0	4445.0
homer__DGGGYGKGGC_KLF5	Topic8	KLF4, KLF5	KLF1, KLF2, KLF3, KLF6, KLF10, KLF11, KLF12, KLF14, KLF15, KLF16, KLF17, SP1, SP3	KLF8	KLF7, SP4, SP6, SP7, SP8, SP9	0.256338	0.000014	835265.51885	699293.016	962918.0	2802.0
predrem__nrMotif818	Topic8	NaN	BRF1, BRF2, CEBPB, CTCF, CUX1, EGR1, ESRRA, EZH2, HDAC2, KLF15, KLF16, MAZ, MXI1, NELFE, PATZ1, POLR2A, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TBX15, VEZF1, WT1, XRCC4, ZNF274, ZNF467	NaN	SP5	0.25633	0.000023	889013.214601	744295.152	514381.0	4604.0
dbcorrdb__CHD1__ENCSR000AQD_1__m4	Topic8	CHD1	NaN	NaN	NaN	0.256302	0.000022	896937.569789	750944.332	522722.0	4663.0
cisbp__M2391	Topic8	KLF5	FOS, IRF1, KLF1, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, KLF2, KLF3, KLF4, KLF6, KLF7, KLF8, KLF9, PBX3, SP1, SP2, SP3, SP4	NaN	SP6, SP7, SP8, SP9	0.256134	0.000011	825716.036818	691395.88	561852.0	4536.0
homer__GGCGGGAAAH_E2F4	Topic8	E2F4	E2F3, E2F6, E2F7, TFDP1	NaN	EVX1, EVX2	0.256051	0.00001	859600.933426	719810.146	180614.0	6694.0
cisbp__M1706	Topic8	NaN	NaN	NaN	NaN	0.255984	0.00001	844201.371328	706947.686	891381.0	2815.0
transfac_pro__M03814	Topic8	KLF5	BRF1, BRF2, CTCF, EGR1, ESRRA, FOS, IRF1, KLF3, KLF9, MAZ, NELFE, NFYA, NFYB, PBX3, POLR2A, RBBP5, SMARCA4, SP1, SP2, SP3, SP4, STAT1	NaN	SP6, SP7, SP8, SP9	0.255426	0.00008	778983.634094	652585.684	1014859.0	2331.0
dbcorrdb__POLR2A__ENCSR000EUU_1__m4	Topic8	POLR2A	NaN	NaN	NaN	0.255398	0.000004	920510.292523	771163.184	322730.0	5656.0
dbcorrdb__POLR2A__ENCSR000EZL_1__m1	Topic8	ELK4, GABPA, PHF8, PML, POLR2A, TAF1	BCLAF1, BRF1, E2F6, ELF1, ELF2, ELK1, ETS1, ETV1, ETV6, EZH2, GABPB1, GTF2F1, HCFC1, MAX, NR2C2, SIN3A, XRCC4, ZNF143	NaN	FLI1, ZNF76	0.255202	0.000001	971424.396041	813927.158	268873.0	6062.0
dbcorrdb__ELF1__ENCSR000BMB_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, SIN3A	E2F4, E2F6, EGR1, EHF, ELF2, ELF4, ELF5, ELK1, ELK3, ERG, ETV2, ETV6, EZH2, FOXP2, GABPB1, IRF1, MXI1, MYC, NR2C2, PML, RBBP5, RELA, SMARCA4, SREBF1, SREBF2, SRF, TAF1, XRCC4, ZNF143, ZNF274	NaN	ERF, ETV3, ETV3L, FLI1	0.255187	0.000001	969309.769764	812163.784	362506.0	5953.0
transfac_pro__M01905	Topic8	NaN	NaN	NaN	NaN	0.255154	0.000027	863971.710377	723919.766	535048.0	4493.0
hocomoco__SP4_HUMAN.H11MO.0.A	Topic8	IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP4	EGR1, EGR2, EGR3, EGR4, FOS, KLF1, KLF3, KLF5, KLF6, KLF9, KLF14, MAZ, PATZ1, SP3, STAT1, VEZF1, ZBTB7B	NaN	E2F4, SP5, SP6, SP7, SP8, SP9	0.255073	0.000029	813467.609633	681640.794	554266.0	4523.0
elemento__CGCCGGC	Topic8	NaN	NaN	NaN	NaN	0.254863	0.000001	883701.965578	740601.172	268082.0	5960.0
taipale_cyt_meth__SP3_NRCCMCGCCCMYN_eDBD	Topic8	KLF13, KLF14, KLF15, SP3, SP8, SP9	KLF10, KLF11, KLF12, KLF16, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, SP1, SP2, SP4	KLF17, KLF18	KLF7, KLF8, SP6, SP7	0.25454	0.000003	916708.185223	768434.884	382765.0	5364.0
transfac_pro__M07250	Topic8	E2F1	NaN	NaN	NaN	0.25448	0.000004	847050.799773	710073.398	598526.0	4464.0
predrem__nrMotif120	Topic8	NaN	NaN	NaN	NaN	0.254414	0.000747	830928.228218	696590.058	870835.0	2811.0
predrem__nrMotif1200	Topic8	CTCF	BRF1, BRF2, CEBPB, CUX1, EGR1, ESRRA, EZH2, HDAC2, KLF16, MAZ, MXI1, NELFE, PATZ1, POLR2A, POLR3G, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TBX15, WT1, XRCC4, ZBTB7B, ZNF148	NaN	ZNF16, ZNF23, ZNF84, ZNF189, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607	0.254411	0.000006	895477.551759	750705.138	370719.0	5314.0
dbcorrdb__POLR2A__ENCSR000EUU_1__m1	Topic8	POLR2A	NaN	NaN	NaN	0.254258	0.000002	930531.345228	780174.348	472650.0	5074.0
elemento__GCGCGCC	Topic8	NaN	NaN	NaN	NaN	0.254126	0.000003	905044.01967	758874.904	220615.0	6236.0
cisbp__M4617	Topic8	ELF1	EGR1, EHF, ELF2, ELF3, ELF4, ELF5, ELK1, ELK3, ELK4, ETV6, GABPA, GABPB1, NR2C2, POLR2A, SIN3A, SRF	NaN	ERF, ETV3, ETV3L	0.254041	0.000001	971441.221788	814596.678	527687.0	5317.0
dbcorrdb__POLR2A__ENCSR000BGO_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, PML, POLR2A, SIN3A	E2F1, E2F6, ELK1, ETV1, ETV4, ETV6, EZH2, FOXP2, GABPB1, IRF1, MXI1, MYC, NRF1, RBBP5, RELA, SRF, TAF1, THAP1, XRCC4, ZNF143, ZNF274	NaN	ERG, FLI1	0.253901	0.000002	950435.090026	797059.57	304053.0	5748.0
predrem__nrMotif2600	Topic8	NaN	NaN	NaN	NaN	0.253887	0.000001	980174.604085	822007.77	201488.0	6440.0
cisbp__M3919	Topic8	SP1	NaN	NaN	NaN	0.253873	0.000036	792985.608246	665031.052	506359.0	4840.0
flyfactorsurvey__CG3065_F1-5_SOLEXA_2.5_FBgn0034946	Topic8	KLF14, KLF15, SP8, SP9	KLF2, KLF3, KLF5, KLF6, KLF9, KLF12, KLF13, KLF16, PBX3, SP1, SP2, SP3, SP4	KLF17, KLF18	KLF7, KLF8, KLF10, KLF11, SP6, SP7	0.253412	0.000004	898193.288488	753503.098	721975.0	4032.0
c2h2_zfs__M3928	Topic8	NaN	NaN	KLF15	SP1, SP2, SP3, SP4	0.253338	0.000004	902691.440928	757315.498	683264.0	4068.0
scertf__badis.RSC3	Topic8	NaN	NaN	NaN	NaN	0.253274	0.000001	868850.011852	728956.952	136392.0	6647.0
cisbp__M1801	Topic8	NaN	NaN	NaN	NaN	0.253243	0.000002	884107.013617	741773.074	399194.0	5766.0
taipale_cyt_meth__KLF16_NCCACRCCCN_eDBD	Topic8	KLF13, KLF15, KLF16	KLF10, KLF11, KLF12, KLF14, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, SP1, SP3, SP4, SP8, SP9	NaN	KLF17, KLF18, KLF7, KLF8, SP2, SP6, SP7	0.253128	0.000005	804797.769386	675285.94	739173.0	3745.0
yetfasco__MAL63_136	Topic8	NaN	NaN	NaN	NaN	0.25302	0.000066	844632.489598	708763.32	620735.0	4246.0
yetfasco__YLL054C_2242	Topic8	NaN	NaN	NaN	NaN	0.252883	0.000004	837335.37158	702706.806	590999.0	4693.0
jaspar__MA0337.1	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.252598	0.000017	804443.225318	675236.262	551729.0	4506.0
hocomoco__KLF5_HUMAN.H11MO.0.A	Topic8	KLF5	KLF1, KLF3, KLF4, KLF6	NaN	KLF8	0.252457	0.000211	815862.140714	684888.36	920938.0	2872.0
jaspar__MA0995.1	Topic8	NaN	NaN	NaN	NaN	0.252399	0.000033	884390.250158	742445.02	315673.0	5792.0
transfac_pro__M01942	Topic8	NaN	NaN	NaN	NaN	0.252099	0.000015	840541.459841	705780.654	661588.0	4053.0
transfac_pro__M05361	Topic8	SP6	KLF10, KLF6, SP2, SP5, SP8	NaN	KLF2, SP7	0.252095	0.000003	996197.281427	836483.25	138307.0	6628.0
elemento__CGGGGCC	Topic8	NaN	NaN	NaN	NaN	0.252064	0.00005	828390.007944	695594.242	489128.0	4615.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIF_1__m1	Topic8	GABPA	BCLAF1, EGR1, ELF1, ELF2, ELK1, ELK3, ELK4, ERF, ERG, ETS1, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, GABPB1, HCFC1, KDM5B, MAX, NR2C2, PHF8, PML, POLR2A, RBBP5, RELA, SIN3A, TAF1	NaN	ETS2, ETV3L, ETV7	0.251894	0.000004	945265.019291	793826.92	319147.0	5679.0
jaspar__MA0404.1	Topic8	NaN	NaN	NaN	NaN	0.251809	0.000002	856426.729038	719263.638	344113.0	5914.0
dbcorrdb__KDM5B__ENCSR000AQA_1__m1	Topic8	KDM5B	GABPA, PHF8, PML, POLR2A, RBBP5	NaN	NaN	0.251766	0.000008	946192.799773	794676.572	404475.0	5455.0
cisbp__M0504	Topic8	NaN	NaN	NaN	NaN	0.25174	0.000002	834330.320388	700739.724	354029.0	5623.0
elemento__CCCGGAG	Topic8	NaN	NaN	NaN	NaN	0.251714	0.000009	869006.00807	729876.638	580097.0	4386.0
transfac_public__M00470	Topic8	TFAP2A, TFAP2C	TFAP2B, TFAP2D, TFAP2E	NaN	NaN	0.251636	0.000046	805305.749212	676411.306	1011570.0	2572.0
transfac_pro__M03211	Topic8	NaN	NaN	NaN	NaN	0.251621	0.00001	878081.064052	737545.868	486282.0	4826.0
elemento__CCCCGGC	Topic8	NaN	NaN	NaN	NaN	0.251574	0.000013	818529.506367	687547.936	608210.0	4065.0
swissregulon__hs__TFAP2B.p2	Topic8	TFAP2B	BRF1, CTCF, E2F6, EZH2, HCFC1, HDAC2, MAZ, MXI1, NELFE, POLR2A, SREBF1, SREBF2, TFAP2A, TFAP2C, TFAP2D, TFAP2E, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.251364	0.00003	885244.117387	743694.928	357176.0	5219.0
elemento__GGCCGCC	Topic8	NaN	NaN	NaN	NaN	0.251321	0.000003	824089.177657	692339.486	461381.0	4881.0
elemento__CCCGGGC	Topic8	NaN	NaN	NaN	NaN	0.251222	0.000016	830420.253562	697706.14	449907.0	4891.0
taipale__KLF16_DBD_GCCMCGCCCMC_repr	Topic8	KLF15, KLF16, KLF9	IRF1, KLF10, KLF11, KLF13, KLF14, KLF2, KLF4, KLF5, SP1, SP2, SP3, SP4, SP8, SP9	NaN	KLF12, KLF17, KLF18, KLF6, KLF7, KLF8, SP6, SP7	0.251054	0.000018	857008.984491	720129.63	726135.0	3659.0
hdpi__ELF2	Topic8	ELF2	BCLAF1, ELF1, ELF5, ELK1, ELK3, ELK4, ETV1, ETV4, FEV, GABPA, HCFC1, PHF8, SIN3A	NaN	ELF4, ERF, ETS2, ETV2, ETV3, ETV3L, ETV5, ETV6, ETV7, FLI1	0.251004	0.000001	874443.124827	734804.53	503409.0	5412.0
cisbp__M0670	Topic8	NaN	NaN	E2F2, E2F3	NaN	0.250989	0.000016	832245.701551	699352.92	421172.0	5272.0
dbcorrdb__EZH2__ENCSR000ATA_1__m2	Topic8	EZH2	NaN	NaN	NaN	0.250941	0.000005	860218.73736	722883.352	430490.0	5066.0
elemento__CGCACGCGC	Topic8	NaN	NaN	NaN	NaN	0.250851	0.000002	973598.638129	818212.602	254503.0	6137.0
jaspar__MA0341.1	Topic8	NaN	NaN	MECOM, PRDM13, PRDM16	NaN	0.250761	0.000461	859062.134409	722001.234	820828.0	3150.0
cisbp__M4620	Topic8	BCLAF1, ELK1, ELK4, GABPA, GABPB1, TAF1	EGR1, ELF1, ELF2, ELF5, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, HCFC1, NR2C2, PHF8, PML, POLR2A, RBBP5, SIN3A, SRF	NaN	ETV3L, ETV7	0.250705	0.000005	971467.849325	816504.612	872657.0	4003.0
cisbp__M4256	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.250593	0.000022	800777.002017	673093.686	706867.0	3905.0
dbcorrdb__POLR2A__ENCSR000BHZ_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.250311	0.000007	923472.331358	776377.272	357322.0	5368.0
cisbp__M1808	Topic8	NaN	NaN	NaN	NaN	0.250235	0.000001	882869.46085	742280.686	537876.0	5208.0
yetfasco__YBR150C_552	Topic8	NaN	NaN	NaN	NaN	0.250225	0.000002	854432.617198	718377.058	360113.0	5855.0
cisbp__M0613	Topic8	NaN	NaN	MBD1	NaN	0.250099	0.000002	898621.12054	755595.194	298910.0	5895.0
dbcorrdb__POLR2A__ENCSR000EAD_1__m1	Topic8	POLR2A	BCLAF1, ELF1, ELK1, ELK4, ETS1, EZH2, GABPA, HCFC1, MXI1, PHF8, PML, RBBP5, SIN3A, TAF1, THAP1, ZNF143	NaN	FLI1	0.25009	0.000004	935596.980456	786691.124	271005.0	5864.0
elemento__TCCCGCC	Topic8	NaN	NaN	NaN	NaN	0.250062	0.000069	858833.457824	722159.16	558057.0	4407.0
cisbp__M0612	Topic8	NaN	NaN	NaN	NaN	0.249988	0.000032	801416.368176	673913.568	582127.0	4506.0
dbcorrdb__POLR2AphosphoS2__ENCSR000DZK_1__m1	Topic8	POLR2A	NaN	NaN	NaN	0.249932	0.000015	911702.599168	766683.696	375074.0	5382.0
elemento__CGGGGGC	Topic8	NaN	NaN	NaN	NaN	0.249775	0.000004	832539.083722	700188.096	502543.0	4540.0
predrem__nrMotif13	Topic8	NaN	NaN	NaN	NaN	0.249766	0.000008	862733.087505	725586.608	571074.0	4534.0
scertf__zhu.ECM22	Topic8	NaN	NaN	NaN	NaN	0.249406	0.000015	927147.431724	779956.228	756154.0	4183.0
hocomoco__TFDP1_HUMAN.H11MO.0.C	Topic8	E2F1, TFDP1	E2F3, E2F4, E2F6, E2F7	NaN	SP4, ZNF583	0.249388	0.000095	832525.601059	700364.76	783936.0	3579.0
elemento__CGGGCGC	Topic8	NaN	NaN	NaN	NaN	0.24937	0.0	887709.604211	746797.93	244204.0	5994.0
cisbp__M6191	Topic8	E2F2	E2F3	NaN	EVX1, EVX2	0.249356	0.000006	953610.274871	802245.736	531352.0	5025.0
predrem__nrMotif2231	Topic8	NaN	NaN	NaN	NaN	0.249324	0.00011	901806.462741	758681.472	596559.0	4410.0
transfac_pro__M07514	Topic8	NaN	ATF3, TAF1	NaN	NaN	0.249275	0.000003	914082.603203	769034.936	346300.0	5405.0
transfac_pro__M07461	Topic8	KLF10, KLF1, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9	SP1	NaN	NaN	0.24926	0.000051	789179.77569	663958.722	807448.0	3382.0
dbcorrdb__ELK1__ENCSR000DZB_1__m1	Topic8	ELF1, ELK1, ELK4, GABPA, GABPB1	BCLAF1, BHLHE40, BRF2, CTCF, EGR1, ELK3, ERF, ERG, ESRRA, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, EZH2, FEV, FLI1, HCFC1, MAX, MXI1, MYC, PHF8, PML, POLR2A, SIN3A, SRF, TAF1, XRCC4, YY1, ZMIZ1, ZNF143	NaN	ETV3L, ETV6, ETV7	0.249203	0.000003	999578.916908	841006.516	480642.0	5486.0
transfac_pro__M01961	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.249173	0.000019	803971.236414	676444.062	551599.0	4505.0
transfac_pro__M05066	Topic8	NaN	NaN	NaN	NaN	0.249066	0.000002	1031771.502585	868174.93	313562.0	6302.0
flyfactorsurvey__Adf1_FlyReg_FBgn0000054	Topic8	NaN	NaN	NaN	NaN	0.248957	0.000001	822056.646829	691764.624	324850.0	5843.0
hocomoco__EGR4_HUMAN.H11MO.0.D	Topic8	EGR4	NaN	NaN	NaN	0.248804	0.000015	778487.135796	655169.748	660223.0	3981.0
swissregulon__sacCer__STP2	Topic8	NaN	NaN	NaN	NaN	0.248429	0.000007	899942.916278	757583.282	573260.0	4450.0
dbcorrdb__POLR2A__ENCSR000DNF_1__m1	Topic8	POLR2A	NaN	NaN	NaN	0.248199	0.000001	953839.60005	803082.184	163934.0	6523.0
swissregulon__hs__PAX5.p2	Topic8	PAX5	EGR1, PAX2, PAX8, SP3	NaN	NaN	0.248187	0.000055	860813.947169	724765.432	489425.0	4783.0
dbcorrdb__BRF1__ENCSR000DOJ_1__m2	Topic8	BRF1, BRF2, CEBPB, CTCF, EGR1, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, RAD21, RBBP5, RCOR1, SMARCA4, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	CREB1, CUX1, E2F1, E2F6, EGR4, ELF1, ELK1, ELK4, ETS1, HIC1, IRF1, KAT2A, KLF16, KLF3, KLF5, MAX, MYC, NFYB, NR2C2, PATZ1, PBX3, PHF8, POLR3G, REST, RREB1, SP1, TAF1, TBX15, WRNIP1, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZNF263, ZNF460	NaN	ZBTB17, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.248073	0.000002	1000831.77279	842720.932	217002.0	6450.0
transfac_pro__M01924	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.24802	0.000025	803010.012609	676175.796	683185.0	3984.0
dbcorrdb__POLR2A__ENCSR000DLY_1__m1	Topic8	PML, POLR2A	BCLAF1, ELF1, ELK1, ELK4, ETS1, EZH2, GABPA, GABPB1, HCFC1, MYC, PHF8, RBBP5, SIN3A, TAF1, THAP1, ZNF143	NaN	FLI1	0.24781	0.000003	934956.09154	787395.574	303390.0	5607.0
predrem__nrMotif2551	Topic8	NaN	NaN	NaN	NaN	0.247786	0.000005	938670.424537	790537.072	273719.0	5980.0
transfac_pro__M04826	Topic8	EP300	NaN	NaN	NaN	0.247611	0.000003	971200.776447	818032.47	674480.0	4700.0
transfac_pro__M01643	Topic8	NaN	NaN	NaN	NaN	0.247595	0.000003	872870.44635	735218.366	280511.0	5978.0
elemento__CCGGCGC	Topic8	NaN	NaN	NaN	NaN	0.247509	0.000001	885892.282058	746230.856	337177.0	5592.0
dbcorrdb__EZH2__ENCSR000ARR_1__m2	Topic8	EZH2	MXI1	NaN	NaN	0.247355	0.000004	907782.801538	764752.262	344755.0	5418.0
dbcorrdb__CHD1__ENCSR000AQD_1__m3	Topic8	CHD1	NaN	NaN	NaN	0.247167	0.000014	891933.847434	751498.306	406416.0	5314.0
dbcorrdb__SAP30__ENCSR000AQJ_1__m1	Topic8	SAP30	KDM5A, TAF1, YY1	NaN	NaN	0.24716	0.000001	922908.15597	777599.19	350992.0	5442.0
predrem__nrMotif1026	Topic8	NaN	NaN	NaN	NaN	0.247112	0.000004	914099.897113	770203.52	214893.0	6229.0
cisbp__M4207	Topic8	NaN	NaN	NaN	NaN	0.247108	0.000003	853128.57622	718832.212	594582.0	4551.0
jaspar__MA1006.1	Topic8	NaN	NaN	NaN	NaN	0.246993	0.000003	1001930.580003	844277.47	188412.0	6576.0
transfac_pro__M09084	Topic8	NaN	EGR1, ELK1, TAF1	NaN	NaN	0.246963	0.000006	998278.327449	841217.646	257424.0	6225.0
hdpi__ETV4	Topic8	ETV4	ELF1, ELF5, ELK1, ELK3, ELK4, ETV1, ETV5, FEV, GABPA	NaN	ELF2, ELF4, ERF, ETS2, ETV2, ETV3, ETV3L, ETV6, ETV7, FLI1	0.246859	0.000004	870177.432102	733323.754	798560.0	3902.0
cisbp__M0571	Topic8	NaN	NaN	NaN	NaN	0.246821	0.000051	836241.712647	704743.868	590321.0	4490.0
cisbp__M0017	Topic8	NaN	ZMIZ1	NaN	NaN	0.246799	0.000006	784007.981087	660734.11	232332.0	6274.0
jaspar__MA0162.2	Topic8	EGR1, EGR2, WT1	CTCF, EGR3, EGR4, IRF1, KLF6, KLF16, MAZ, PATZ1, SP1, SP2, SP3, SP4, TEAD2	NaN	ZBTB17	0.246599	0.000023	870146.498298	733429.974	594645.0	4252.0
transfac_pro__M03209	Topic8	NaN	NaN	NaN	NaN	0.2465	0.000001	889961.852225	750183.556	281983.0	5808.0
transfac_pro__M00939	Topic8	E2F1, E2F3, E2F4, E2F7, TFDP1	E2F2, E2F5	NaN	NaN	0.246404	0.000008	898688.966839	757590.302	692918.0	4100.0
dbcorrdb__NFYB__ENCSR000DNR_1__m2	Topic8	NFYA, NFYB, SP1	FOS, IRF1, KLF5, KLF6, KLF9, PBX3, SP2, SP3, SP4	NaN	E2F4, SP6, SP7, SP8, SP9	0.246379	0.000004	877998.575337	740161.16	513170.0	4588.0
cisbp__M1891	Topic8	ELK1, ELK4, HCFC1	BCLAF1, EGR1, ELF1, ELF2, ELK3, ETS1, ETV1, ETV3, GABPB1, PHF8, PML, POLR2A, SIN3A, SRF, TAF1	GABPA	ERF, ERG, ETV2, ETV3L, ETV4, ETV5, FLI1	0.246189	0.000006	975392.657168	822373.78	812272.0	4163.0
transfac_pro__M05051	Topic8	NaN	NaN	NaN	NaN	0.245819	0.000002	1027876.686925	866846.562	101191.0	7061.0
dbcorrdb__CHD1__ENCSR000AQD_1__m2	Topic8	CHD1	NaN	NaN	NaN	0.245764	0.000006	890642.274871	751140.188	477351.0	4940.0
homer__GGGGGGGG_Maz	Topic8	MAZ	BRF1, CEBPB, CUX1, KLF15, KLF16, RCOR1, REST, SP4, SUPT20H, TBX15, TRIM28	NaN	NaN	0.245568	0.000023	801556.658933	676099.986	653220.0	3981.0
dbcorrdb__POLR2A__ENCSR000DYO_1__m2	Topic8	POLR2A	ZNF143	NaN	NaN	0.245528	0.000001	938454.854243	791593.184	228263.0	6078.0
dbcorrdb__CHD2__ENCSR000EBT_1__m1	Topic8	BRCA1, CHD2, ZBTB33	ETS1, MXI1, NR3C1, RCOR1	NaN	NaN	0.245399	0.000003	959905.90846	809759.736	205217.0	6371.0
transfac_pro__M04983	Topic8	NaN	NaN	NaN	NaN	0.245332	0.000072	824088.30488	695218.798	841673.0	2940.0
predrem__nrMotif2384	Topic8	NaN	NaN	NaN	NaN	0.245318	0.000008	945710.78149	797829.62	303665.0	5857.0
dbcorrdb__EZH2__ENCSR000ATA_1__m3	Topic8	EZH2	NaN	NaN	NaN	0.245318	0.000006	856300.902282	722401.206	507064.0	4535.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BIL_1__m2	Topic8	NaN	NaN	NaN	NaN	0.245314	0.000036	919993.572689	776135.968	466123.0	5030.0
transfac_pro__M01936	Topic8	NaN	NaN	NaN	NaN	0.245228	0.000003	859199.18144	724891.19	344910.0	5911.0
hocomoco__AP2D_HUMAN.H11MO.0.D	Topic8	TFAP2D	TFAP2E	NaN	NaN	0.245215	0.000008	803470.484428	677880.08	418295.0	5313.0
predrem__nrMotif930	Topic8	NaN	NaN	NaN	NaN	0.245133	0.000006	926286.803051	781543.438	257613.0	6005.0
predrem__nrMotif2136	Topic8	NaN	NaN	NaN	NaN	0.245093	0.000017	946706.516076	798794.264	367405.0	5558.0
cisbp__M4616	Topic8	EGR1	BRF1, BRF2, CEBPB, CTCF, CUX1, EGR2, EGR3, EGR4, ESRRA, EZH2, HDAC2, KLF16, KLF6, MAZ, MXI1, NELFE, PATZ1, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TBX15, TEAD2, WT1, XRCC4, ZMIZ1, ZNF274, ZNF467	NaN	ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.244947	0.00002	917819.275501	774498.8	440167.0	5052.0
cisbp__M0076	Topic8	NaN	TAF1	NaN	NaN	0.244876	0.000001	907803.530702	766084.73	198465.0	6338.0
cisbp__M0092	Topic8	NaN	NaN	NaN	NaN	0.244826	0.000086	896100.416593	756234.794	972395.0	3165.0
predrem__nrMotif936	Topic8	NaN	NaN	NaN	NaN	0.244631	0.000025	940121.150801	793491.954	459074.0	5170.0
transfac_pro__M05665	Topic8	NaN	SP2	SP3	SP6	0.244441	0.000005	1014704.158618	856555.204	102015.0	6855.0
taipale__Tcfap2a_DBD_NSCCNNNGGSN_repr	Topic8	TFAP2B, TFAP2C	TFAP2E	TFAP2A	TFAP2D	0.244281	0.000172	865374.897617	730580.936	716641.0	3754.0
predrem__nrMotif1241	Topic8	NaN	NaN	NaN	NaN	0.244162	0.000004	934388.455554	788910.106	310924.0	5862.0
transfac_pro__M00938	Topic8	E2F1	E2F3, E2F5	NaN	EVX1, EVX2	0.24402	0.000044	867723.53272	732696.448	1037463.0	2932.0
dbcorrdb__NR2C2__ENCSR000EWH_1__m1	Topic8	NR2C2	NaN	NaN	NaN	0.243988	0.00002	877966.018787	741361.25	328625.0	5693.0
elemento__CCGGCCC	Topic8	NaN	NaN	NaN	NaN	0.243956	0.000018	821547.587946	693736.446	564993.0	4263.0
cisbp__M0148	Topic8	NaN	NaN	NaN	NaN	0.243877	0.000005	901630.901778	761403.106	491768.0	5061.0
cisbp__M1720	Topic8	NaN	NaN	NaN	NaN	0.243863	0.000015	825730.390619	697313.714	553857.0	4791.0
dbcorrdb__TAF1__ENCSR000BGS_1__m1	Topic8	PHF8, TAF1, YY1	KDM5A, POLR2A, TAF7, THAP1	NaN	TAF1L, YY2	0.243736	0.000009	902853.06317	762509.376	377300.0	5212.0
transfac_pro__M01629	Topic8	NaN	NaN	NaN	NaN	0.243712	0.000007	965889.605598	815760.716	411220.0	5499.0
cisbp__M0522	Topic8	NaN	GLIS1, GLIS3	NaN	NaN	0.243662	0.000025	799783.780734	675496.53	742275.0	3747.0
hocomoco__FLI1_MOUSE.H11MO.0.A	Topic8	BCLAF1, ELF1, ELK1, ELK4, ETS1, ETV1, GABPA, PHF8, POLR2A	EGR1, ELF2, ELF4, ELK3, ERF, ERG, ETV2, ETV3, ETV4, ETV5, FEV, GABPB1, HCFC1, KDM5A, PML, SIN3A, SRF, TAF1, ZNF143	FLI1	ETS2, ETV6, ETV7	0.243456	0.000019	899771.347245	760054.466	623635.0	4627.0
cisbp__M0526	Topic8	NaN	NaN	NaN	NaN	0.243439	0.000021	861707.460472	727909.376	556151.0	4439.0
cisbp__M0091	Topic8	NaN	NaN	NaN	NaN	0.243404	0.000012	973975.116631	822765.272	355294.0	5737.0
dbcorrdb__EZH2__ENCSR000ARH_1__m4	Topic8	EZH2	NaN	NaN	NaN	0.243288	0.000033	830249.152692	701409.386	839106.0	3148.0
cisbp__M4890	Topic8	NaN	KLF1, KLF14, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP3, SP4, SP8, SP9	KLF12, KLF3, KLF7, KLF8	KLF10, KLF11, KLF17, KLF18, SP2, SP6, SP7	0.243171	0.000044	844056.635733	713131.942	675159.0	4023.0
dbcorrdb__TRIM28__ENCSR000EYC_1__m5	Topic8	BRF1, CEBPB, EZH2, POLR2A, POLR3G, TRIM28, XRCC4	CHD1, HDAC2, MAZ, MXI1, NELFE, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, ZMIZ1, ZNF143, ZNF274	NaN	ZIC1, ZIC2, ZIC3	0.243049	0.000015	824042.102131	696280.636	489138.0	4511.0
predrem__nrMotif548	Topic8	NaN	NaN	NaN	NaN	0.242919	0.000026	907392.480015	766777.4	428243.0	5070.0
dbcorrdb__POLR2A__ENCSR000EZQ_1__m3	Topic8	POLR2A	ATF3, BRF1, CREB1, CTCF, EZH2, MAX, MXI1, MYC, RAD21, SREBF1, SREBF2	NaN	NaN	0.242913	0.000025	881709.941495	745077.598	440396.0	4787.0
cisbp__M6337	Topic8	MBD2	NaN	NaN	NaN	0.242801	0.000002	918095.088261	775884.782	207374.0	6333.0
transfac_pro__M01561	Topic8	NaN	NaN	NaN	NaN	0.242448	0.000002	1035241.520237	875099.806	197832.0	6659.0
dbcorrdb__POLR2A__ENCSR000FAX_1__m1	Topic8	POLR2A	TAF1	NaN	NaN	0.242381	0.000014	951110.440802	804020.286	317635.0	5739.0
dbcorrdb__HDAC1__ENCSR000AQF_1__m4	Topic8	HDAC1	NaN	NaN	NaN	0.242275	0.000028	863550.20174	730054.814	588123.0	4224.0
elemento__CGGCTCC	Topic8	NaN	NaN	NaN	NaN	0.242188	0.000056	861020.570798	727960.128	530787.0	4456.0
predrem__nrMotif813	Topic8	NaN	NaN	NaN	NaN	0.242034	0.000169	854540.051822	722558.304	550560.0	4325.0
jaspar__MA0470.1	Topic8	E2F1, E2F4	E2F6	NaN	E2F3	0.241567	0.000007	978479.888791	827623.578	168632.0	6442.0
predrem__nrMotif1298	Topic8	NaN	NaN	NaN	NaN	0.24156	0.000018	923250.985122	780913.452	256222.0	6032.0
cisbp__M1555	Topic8	NaN	NaN	NaN	NaN	0.241457	0.000033	886023.531459	749479.138	954720.0	3102.0
predrem__nrMotif2611	Topic8	NaN	NaN	NaN	NaN	0.24142	0.000009	860807.261505	728167.568	343675.0	5365.0
dbcorrdb__POLR2A__ENCSR000EAU_1__m1	Topic8	POLR2A, TAF1	BCLAF1, ELF1, ELF2, ELK1, ELK4, ETS1, ETV6, EZH2, GABPA, GABPB1, GTF2F1, HCFC1, MYC, NR2C2, PHF8, PML, SIN3A, ZNF143, ZNF274	NaN	FLI1	0.241397	0.000003	952153.210566	805450.82	296257.0	5801.0
cisbp__M1943	Topic8	NaN	NaN	NaN	NaN	0.241303	0.000032	784314.930904	663515.588	515808.0	4532.0
dbcorrdb__BCLAF1__ENCSR000BJZ_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, RBBP5, SIN3A, TAF1	BRF1, E2F6, ELF2, ELK1, ELK3, ERF, ERG, ETV1, ETV3, ETV4, ETV5, ETV6, EZH2, FEV, FLI1, FOXP2, GABPB1, KDM5A, MAX, MXI1, MYC, NR2C2, PML, RELA, XRCC4, ZMIZ1, ZNF143, ZNF274	NaN	ETS2, ETV2, ETV7	0.241175	0.000014	909052.016517	769108.742	681804.0	4252.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BOV_1__m4	Topic8	NaN	POLR2A	NaN	NaN	0.241174	0.000023	914873.77506	774034.782	542251.0	4828.0
cisbp__M0482	Topic8	NaN	NaN	NaN	NaN	0.241138	0.000082	800331.315975	677142.494	874441.0	3147.0
hdpi__NRL	Topic8	NRL	NaN	NaN	NaN	0.241047	0.000006	826406.268945	699247.862	698707.0	3967.0
predrem__nrMotif717	Topic8	NaN	CTCF, CTCFL	NaN	NaN	0.241	0.00001	913030.503467	772568.746	310034.0	5682.0
cisbp__M0025	Topic8	NaN	NaN	NaN	NaN	0.240882	0.000008	936649.272601	792618.842	358466.0	5545.0
hocomoco__KLF16_HUMAN.H11MO.0.D	Topic8	KLF16	BRF1, BRF2, CEBPB, CPSF4, CTCF, CUX1, EGR1, EGR2, EGR3, EGR4, EZH2, HDAC2, KLF2, KLF10, KLF11, KLF15, MAZ, MXI1, NELFE, PATZ1, RAD21, RBBP5, RCOR1, REST, RREB1, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TBX15, XRCC4, ZBTB17, ZNF148, ZNF263, ZNF460, ZNF467	NaN	SP5, WT1, ZNF16, ZNF23, ZNF84, ZNF189, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607	0.240867	0.000075	843463.656412	713769.728	617063.0	4029.0
dbcorrdb__SUZ12__ENCSR000EUQ_1__m1	Topic8	SUZ12	NaN	NaN	NaN	0.240533	0.00005	896167.129366	758545.24	582694.0	4401.0
dbcorrdb__POLR2A__ENCSR000DKT_1__m1	Topic8	POLR2A	BCLAF1, ELF1, ELF2, ELK1, ELK4, ETV6, GABPA, GABPB1, GTF2F1, PHF8, PML, RELA, SIN3A, SUZ12, TAF1, TAF7	NaN	FLI1	0.240225	0.000003	943596.593746	798861.53	242966.0	6202.0
elemento__TCCCGGC	Topic8	NaN	NaN	NaN	NaN	0.240188	0.000023	851209.915521	720664.062	514799.0	4576.0
cisbp__M6199	Topic8	EGR2	EGR1, EGR3, EGR4	NaN	NaN	0.240146	0.00008	863968.107174	731487.018	608009.0	4164.0
scertf__zhu.RDR1	Topic8	NaN	NaN	NaN	NaN	0.240104	0.000012	898913.116883	761095.634	382904.0	5824.0
hocomoco__EGR1_HUMAN.H11MO.0.A	Topic8	EGR1, EGR2	EGR3, EGR4, KLF1, KLF3, KLF6, KLF16, MAZ, PATZ1, SP1, SP2, TBX15, TEAD2, WT1, ZBTB17	NaN	NaN	0.239986	0.000366	822522.938091	696474.292	788009.0	3471.0
dbcorrdb__STAT1__ENCSR000DZM_1__m5	Topic8	STAT1	NaN	NaN	NaN	0.239976	0.000088	835750.540411	707679.824	789304.0	3442.0
dbcorrdb__EZH2__ENCSR000AQE_1__m9	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAX, MXI1, MYC, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, TRIM28, XRCC4, ZMIZ1, ZNF274	ATF3, BCLAF1, BHLHE40, CNOT3, CREB1, E2F1, E2F6, EGR1, ELF1, ELK1, ELK4, ETS1, GABPA, HCFC1, HIC1, HMGN3, JUND, KAT2A, MAZ, NR2C2, NRF1, PHF8, RCOR1, SIN3A, SP1, SP2, SP3, SP4, TAF1, TFAP2A, TFAP2B, TFAP2C, UBTF, USF1, WRNIP1, ZBTB7A, ZC3H11A, ZEB1, ZFX, ZNF143	NaN	ZFY	0.239883	0.000003	1011705.004665	856726.082	194626.0	6630.0
cisbp__M1280	Topic8	NaN	NaN	NaN	NaN	0.239729	0.000004	996402.131131	843857.496	227203.0	6306.0
transfac_pro__M09074	Topic8	NaN	POLR2A, TAF1	NaN	NaN	0.239723	0.000006	1024967.759551	868053.334	428209.0	5877.0
transfac_pro__M00919	Topic8	E2F1, E2F3, E2F4, E2F7, TFDP1	E2F2, E2F5	NaN	NaN	0.239632	0.000017	921336.23944	780336.216	511956.0	4935.0
hocomoco__E2F3_MOUSE.H11MO.0.A	Topic8	E2F1	E2F4, E2F6	E2F3	NaN	0.239505	0.000158	844788.888286	715566.6	759764.0	3564.0
dbcorrdb__SREBF1__ENCSR000DYU_1__m5	Topic8	SREBF1	NaN	NaN	NaN	0.239265	0.000209	819455.930778	694224.016	436953.0	5060.0
taipale_cyt_meth__SP9_NCCACGCCCMYN_eDBD_meth	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF11, KLF16, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, SP2, SP4	KLF10, KLF17, KLF18	KLF12, KLF7, KLF8, SP6, SP7	0.239111	0.000009	879581.157735	745240.262	619336.0	4271.0
transfac_pro__M01783	Topic8	SP2	NFYA	NaN	NaN	0.239104	0.000065	822733.238936	697078.306	860015.0	3040.0
elemento__GCCACGCC	Topic8	NaN	KLF9	NaN	KLF7, SP4	0.238931	0.000048	846776.338545	717535.434	225975.0	6403.0
cisbp__M0465	Topic8	NaN	NaN	NaN	NaN	0.238776	0.00004	825495.112218	699577.382	574770.0	4484.0
transfac_pro__M00918	Topic8	E2F1, E2F3, E2F4, E2F7, TFDP1	E2F2, E2F5, RB1	NaN	NaN	0.23877	0.000012	899574.357584	762359.802	664848.0	4218.0
taipale_cyt_meth__EGR1_NMCGCCCACGCMN_eDBD_meth	Topic8	EGR1, EGR2, EGR3, EGR4	KLF1, WT1	NaN	NaN	0.238768	0.00042	816007.579246	691541.09	925724.0	2959.0
jaspar__MA0362.1	Topic8	NaN	NaN	NaN	NaN	0.238761	0.000006	931156.174253	789129.522	212276.0	6378.0
transfac_pro__M01925	Topic8	NaN	NaN	NaN	NaN	0.238709	0.000013	864637.806204	732783.346	243249.0	6499.0
dbcorrdb__THAP1__ENCSR000BNN_1__m2	Topic8	THAP1	ELF1, PHF8, POLR2A, TAF1	NaN	NaN	0.238618	0.000004	925334.838482	784273.872	234526.0	6137.0
predrem__nrMotif968	Topic8	NaN	NaN	NaN	NaN	0.238616	0.000058	950919.470559	805959.502	300681.0	5797.0
transfac_pro__M08875	Topic8	E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7	NaN	NaN	NaN	0.238578	0.000017	839891.940613	711875.784	415826.0	5506.0
flyfactorsurvey__brk_FlyReg_FBgn0024250	Topic8	NaN	NaN	NaN	NaN	0.238512	0.00002	808069.989156	684935.752	933594.0	2934.0
dbcorrdb__TAF1__ENCSR000BGS_1__m2	Topic8	ELK4, GABPA, POLR2A, TAF1	BCLAF1, BRF1, CREB1, E2F6, EGR1, ELF1, ELK1, ELK3, ERG, ETS1, ETV1, ETV3, ETV4, ETV5, ETV6, EZH2, FEV, FLI1, GABPB1, GTF2F1, HCFC1, MXI1, NELFE, NR2C2, PHF8, PML, RBBP5, SIN3A, XRCC4, ZNF143, ZNF274	NaN	ETS2, ETV2, ETV7	0.238493	0.000004	986263.106418	835986.466	186220.0	6521.0
dbcorrdb__POLR2A__ENCSR000EAM_1__m1	Topic8	ELF1, ELK4, GABPA, PHF8, PML, POLR2A, TAF1	BCLAF1, BRF1, CREB1, E2F6, ESRRA, ETS1, EZH2, GTF2F1, HCFC1, MAX, MXI1, MYC, NR2C2, RBBP5, SIN3A, SMARCA4, SREBF1, XRCC4, ZMIZ1, ZNF143, ZNF274	NaN	FLI1	0.238483	0.000005	939117.731055	796030.288	263664.0	5848.0
dbcorrdb__POLR2A__ENCSR000BIK_1__m1	Topic8	POLR2A, TAF1	NaN	NaN	NaN	0.238474	0.000009	922349.038583	781821.368	388928.0	5267.0
cisbp__M6123	Topic8	NaN	CUX1, EGR2, KLF16, MAZ, PATZ1, PAX4, RCOR1, REST, SP1, TBX15, VEZF1, ZBTB17, ZNF148, ZNF467	ZNF281	SP5	0.238412	0.000058	888065.473963	752793.304	393513.0	5366.0
taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	Topic8	ETV5, HES7	NaN	NaN	NaN	0.238284	0.000034	944061.027487	800330.816	430316.0	5263.0
cisbp__M4539	Topic8	ELK1, ELK4, ETV1, GABPA, GABPB1	BCLAF1, EGR1, ELF1, ELF2, ELF4, ELK3, ERF, ERG, ETS1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, HCFC1, PHF8, POLR2A, SIN3A, SRF, TAF1	NaN	ETS2, ETV3L, ETV6, ETV7	0.23827	0.000013	963371.526037	816709.102	683165.0	4578.0
hocomoco__ZN148_HUMAN.H11MO.0.D	Topic8	ZNF148	CUX1, EGR2, KLF16, MAZ, PATZ1, PAX4, RCOR1, REST, SP1, TBX15, VEZF1, ZBTB17, ZNF281, ZNF467	NaN	SP5, ZNF16, ZNF23, ZNF84, ZNF189, ZNF429, ZNF471, ZNF502, ZNF607	0.238217	0.000543	817248.474341	692857.056	636495.0	4017.0
transfac_pro__M05444	Topic8	KLF6	KLF2, KLF7, KLF8, SP2, SP6	NaN	KLF13, SP5	0.23806	0.000009	1009492.831295	855933.314	172086.0	6633.0
dbcorrdb__EZH2__ENCSR000ARH_1__m8	Topic8	EZH2	NaN	NaN	NaN	0.237841	0.000158	833540.842643	706853.588	678905.0	3926.0
dbcorrdb__SIN3A__ENCSR000BPB_1__m1	Topic8	SIN3A	NaN	NaN	NaN	0.237812	0.000016	908119.850965	770113.168	542910.0	4888.0
jaspar__MA0979.1	Topic8	NaN	NaN	NaN	NaN	0.237657	0.00002	805773.851973	683394.09	822990.0	3312.0
transfac_pro__M00306	Topic8	NaN	NaN	NaN	NaN	0.237495	0.000036	883328.496533	749254.214	752536.0	3814.0
dbcorrdb__POLR2A__ENCSR000DKT_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.237453	0.000012	931632.566007	790249.642	334744.0	5519.0
elemento__CCTCCGC	Topic8	NaN	NaN	NaN	NaN	0.237404	0.000092	852496.652251	723147.396	632965.0	4032.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BML_1__m2	Topic8	NaN	NaN	NaN	NaN	0.237335	0.000007	902011.099609	765185.872	293383.0	5858.0
dbcorrdb__POLR2A__ENCSR000EZA_1__m1	Topic8	POLR2A	NaN	NaN	NaN	0.237225	0.000002	936600.792334	794589.41	238404.0	6027.0
transfac_pro__M05143	Topic8	NaN	NaN	NaN	NaN	0.237214	0.000008	1011314.407893	857980.962	145132.0	6741.0
transfac_pro__M00431	Topic8	E2F1	E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, RB1, TFDP1, TFDP2	NaN	EVX1, EVX2	0.237129	0.000013	840173.971756	712830.444	641571.0	4391.0
hocomoco__SP5_MOUSE.H11MO.1.C	Topic8	NaN	EGR2, FOS, MAZ, NFYB, PATZ1, PBX3, SP1, SP2, SP3, SP4, VEZF1, WT1, ZBTB17, ZNF263, ZNF341, ZNF467	SP5	NaN	0.236869	0.000201	808654.075526	686211.524	896087.0	3063.0
elemento__CTCCGCCC	Topic8	NaN	NaN	NaN	NaN	0.236839	0.000191	810309.988274	687630.984	291863.0	5829.0
transfac_pro__M07281	Topic8	KLF1	KLF3, KLF4, KLF5	NaN	KLF8	0.236835	0.000389	812669.940613	689635.54	948332.0	2803.0
predrem__nrMotif572	Topic8	NaN	NaN	NaN	NaN	0.236771	0.000018	897051.70319	761276.292	474333.0	4857.0
flyfactorsurvey__luna_SOLEXA_5_FBgn0040765	Topic8	NaN	KLF2, KLF3, KLF4, KLF5, KLF9, KLF12, KLF14	KLF6, KLF7, KLF8	KLF17, KLF18, SP1, SP2, SP3, SP4, SP6, SP7, SP8, SP9	0.236731	0.000028	865713.854999	734702.16	691495.0	3956.0
hocomoco__PROX1_HUMAN.H11MO.0.D	Topic8	PROX1	NaN	NaN	NaN	0.236698	0.000076	841540.164796	714203.16	912463.0	3132.0
elemento__GCGCCGC	Topic8	NaN	NaN	NaN	NaN	0.236627	0.000009	881988.23011	748567.598	228542.0	6051.0
hocomoco__KLF13_HUMAN.H11MO.0.D	Topic8	KLF13	KLF9, KLF14, KLF15, SP1, SP3, SP4, SP8, SP9	NaN	KLF17, KLF18, SP2, SP6, SP7	0.236461	0.000006	989615.825369	840010.898	225717.0	6326.0
cisbp__M4568	Topic8	BCLAF1, ELF1, ELK1, ELK4, GABPA, HCFC1, PHF8, POLR2A	EGR1, ELF2, ELF4, ELF5, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, GABPB1, KDM5A, NR2C2, PML, RBBP5, RELA, SIN3A, SRF, TAF1, ZNF143	NaN	ETV3L, ETV7	0.236427	0.000006	976398.392384	828811.046	512803.0	5203.0
cisbp__M0695	Topic8	GABPA	BCLAF1, ELF1, ELF2, ELF4, ELK3, ELK4, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, GABPB1, SRF	ELK1	ETV3L, ETV7	0.236388	0.000014	932002.282058	791146.662	925785.0	3528.0
dbcorrdb__TAF1__ENCSR000BHT_1__m2	Topic8	TAF1	BCLAF1, ELF1, ELK1, ELK4, ETS1, ETV1, ETV6, GABPA, GABPB1, HCFC1, PHF8, POLR2A, SIN3A, THAP1	NaN	ERG, FLI1	0.236288	0.000006	933959.389989	792863.074	291385.0	5839.0
dbcorrdb__POLR2A__ENCSR000BHN_1__m1	Topic8	POLR2A	ATF3, ELK1, MYC, TAF1, YY1	NaN	NaN	0.236083	0.000035	940817.349767	798798.384	335996.0	5587.0
cisbp__M6201	Topic8	EGR4	NaN	NaN	NaN	0.23605	0.000026	881442.845038	748404.016	394740.0	5159.0
taipale_cyt_meth__KLF15_NCCMCGCCCMYN_FL	Topic8	KLF13, KLF14, KLF15, KLF16, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, SP2, SP4	KLF17, KLF18	KLF12, KLF7, KLF8, SP6, SP7	0.236026	0.000079	812388.414954	689783.682	562038.0	4609.0
hocomoco__SP1_MOUSE.H11MO.0.A	Topic8	EGR1, IRF1, PBX3, SP2, SP3, SP4	BRF1, BRF2, CEBPB, CTCF, CUX1, EGR2, EGR3, EGR4, ESRRA, EZH2, FOS, HDAC2, KAT2A, KLF1, KLF3, KLF5, KLF6, KLF9, KLF15, MAZ, MXI1, NELFE, NFYA, NFYB, PATZ1, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SREBF1, SREBF2, STAT1, SUPT20H, TBX15, VEZF1, WT1, XRCC4, ZBTB7B, ZBTB17, ZNF148, ZNF263, ZNF281, ZNF341, ZNF444, ZNF467	SP1	SP5, SP6, SP7, SP8, SP9	0.235895	0.000072	867470.927248	736619.944	461601.0	4742.0
yetfasco__YDR463W_660	Topic8	NaN	NaN	NaN	NaN	0.235856	0.00001	861344.357332	731437.032	469130.0	4959.0
transfac_pro__M01833	Topic8	NaN	NaN	NaN	NaN	0.235832	0.000027	833096.432606	707461.616	557295.0	4579.0
transfac_pro__M00915	Topic8	TFAP2A, TFAP2B, TFAP2C	EZH2, MXI1, POLR2A, ZMIZ1, ZNF274	NaN	NaN	0.235795	0.00002	780271.161896	662619.632	787045.0	3318.0
cisbp__M0419	Topic8	NaN	NaN	EGR1	EGR2, EGR3, EGR4	0.235661	0.000128	813106.703442	690567.972	885741.0	3071.0
predrem__nrMotif745	Topic8	NaN	NaN	NaN	NaN	0.235602	0.000017	928149.465641	788305.71	492942.0	4973.0
dbcorrdb__IRF1__ENCSR000EGT_1__m1	Topic8	FOS, IRF1, NFYA, NFYB, PBX3, SP1, SP2, SP3, SP4	BRF1, BRF2, CTCF, EGR1, EZH2, KLF1, KLF12, KLF15, KLF16, KLF3, KLF5, KLF6, KLF9, MAZ, PATZ1, RAD21, SMARCA4, SREBF1, SREBF2, STAT1, SUPT20H, XRCC4, ZBTB7A, ZBTB7B	NaN	E2F4, SP6, SP7, SP8, SP9	0.235333	0.000005	1000024.039213	849509.41	391656.0	5919.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BOV_1__m5	Topic8	NaN	NaN	NaN	NaN	0.235307	0.000014	873565.568276	742097.56	348356.0	5648.0
dbcorrdb__POLR2A__ENCSR000BQB_1__m1	Topic8	POLR2A	NaN	NaN	NaN	0.235233	0.000005	916891.902156	778943.478	291806.0	5589.0
elemento__CCGCGGC	Topic8	NaN	NaN	NaN	NaN	0.235008	0.000002	855868.368806	727214.28	233614.0	6036.0
transfac_pro__M05391	Topic8	NaN	KLF6, KLF7, KLF8, SP2, SP6	KLF2	KLF13, SP5	0.234971	0.000011	1008757.280923	857142.986	276248.0	6296.0
cisbp__M1806	Topic8	NaN	NaN	NaN	NaN	0.234958	0.00001	892514.585929	758378.204	202314.0	6474.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BPA_1__m1	Topic8	POLR2A	PML, TAF1	NaN	NaN	0.234881	0.000008	895305.519733	760790.5	462393.0	4927.0
predrem__nrMotif1018	Topic8	NaN	CTCF, SP3	NaN	SP1	0.234853	0.000004	911735.158996	774766.792	177144.0	6427.0
predrem__nrMotif1742	Topic8	NaN	NaN	NaN	NaN	0.234839	0.000016	966382.658051	821212.508	219923.0	6470.0
cisbp__M4323	Topic8	NaN	NaN	NaN	NaN	0.23481	0.000172	836421.317741	710788.29	904124.0	3030.0
homer__AACCGGAAGT_ELF1	Topic8	ELF1	BCLAF1, EHF, ELF2, ELF3, ELF4, ELF5, ELK1, ELK3, ELK4, EP300, ERG, ETS2, ETV1, ETV4, ETV6, FEV, FLI1, GABPA, GABPB1, SRF	NaN	ERF, ETS1, ETV3, ETV3L, ETV5, ETV7	0.234769	0.000011	924528.034296	785683.592	890166.0	3683.0
transfac_pro__M07329	Topic8	SP7	NaN	NaN	NaN	0.23475	0.000114	782337.851091	664855.796	914358.0	2885.0
transfac_pro__M07594	Topic8	NaN	NaN	NaN	NaN	0.23466	0.000016	889736.054848	756173.586	620290.0	4829.0
scertf__zhu.ASG1	Topic8	NaN	NaN	NaN	NaN	0.234466	0.000019	936189.72349	795760.664	327742.0	5686.0
taipale__SP3_DBD_GCCMCGCCCMC	Topic8	KLF11, SP3	KLF10, KLF13, KLF14, KLF15, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP2, SP4, SP8, SP9, WT1	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.234255	0.000038	819810.942882	696940.854	463007.0	5120.0
transfac_pro__M09080	Topic8	NaN	NaN	NaN	NaN	0.23412	0.000022	983245.052705	835958.312	1147301.0	3366.0
transfac_pro__M01991	Topic8	ELK1, ELK3, ELK4, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV5, FEV, FLI1, GABPA	BCLAF1, ELF1, ELF2, ELF4, ETV6, GABPB1, POLR2A, SRF, TAF1	ETV4	ETV3L, ETV7, SPIC	0.233994	0.000022	922620.768125	784483.72	936809.0	3476.0
elemento__CGCCTCC	Topic8	NaN	NaN	NaN	NaN	0.233933	0.000073	847575.404237	720705.14	608831.0	4106.0
elemento__GGCCCCC	Topic8	NaN	NaN	NaN	NaN	0.233847	0.000111	826505.227966	702830.376	638182.0	3979.0
cisbp__M5066	Topic8	CUX1, RCOR1, REST	CEBPB, KLF16, MAZ, PAX4, RBBP5, RREB1, SP1, SUPT20H, TBX15, ZNF460, ZNF740	NaN	EGR2, EGR3, EGR4, SP5, ZNF16, ZNF189, ZNF23, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.233787	0.000495	861944.581768	732997.54	989841.0	2960.0
cisbp__M1794	Topic8	NaN	NaN	NaN	NaN	0.233625	0.000011	882042.475098	750173.062	497668.0	5396.0
jaspar__MA0441.1	Topic8	NaN	NaN	NaN	NaN	0.233621	0.000173	831062.757282	706817.026	858691.0	3244.0
transfac_pro__M08874	Topic8	E2F1	E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, TFDP1	NaN	NaN	0.233607	0.000055	836149.035305	711149.45	216433.0	6556.0
cisbp__M0678	Topic8	NaN	NaN	NaN	NaN	0.233511	0.000016	888799.378136	755979.296	393806.0	5130.0
predrem__nrMotif657	Topic8	NaN	NaN	NaN	NaN	0.233483	0.000007	981609.91136	834936.476	339212.0	5952.0
dbcorrdb__POLR2A__ENCSR000FAY_1__m1	Topic8	POLR2A, TAF1	PML	NaN	NaN	0.233398	0.00001	939427.048165	799104.076	282430.0	5890.0
elemento__TCCCCGC	Topic8	NaN	NaN	NaN	NaN	0.233385	0.000078	846365.960409	719949.886	634208.0	4054.0
cisbp__M1775	Topic8	NaN	NaN	NaN	NaN	0.233281	0.000021	828238.52465	704580.904	549491.0	4856.0
elemento__AGCCGCG	Topic8	NaN	NaN	NaN	NaN	0.233273	0.000017	901828.034674	767187.794	265821.0	5808.0
dbcorrdb__EZH2__ENCSR000ARH_1__m6	Topic8	EZH2	NaN	NaN	NaN	0.233264	0.000277	831783.957509	707605.44	699229.0	3776.0
dbcorrdb__TAF7__ENCSR000BLU_1__m2	Topic8	TAF7	NaN	NaN	NaN	0.233147	0.000012	905689.369689	770539.61	250110.0	6089.0
tfdimers__MD00569	Topic8	SP1, SP2, SP3, SP4, ZBTB14	NaN	NaN	NaN	0.232996	0.00005	820254.751608	697926.806	714368.0	3516.0
dbcorrdb__POLR2A__ENCSR000EFK_1__m1	Topic8	POLR2A, TAF1, YY1	ATF3, KDM5A, MYC, PHF8, RBBP5, TAF7, THAP1	NaN	TAF1L	0.232881	0.000015	909296.008448	773750.712	319015.0	5464.0
predrem__nrMotif1056	Topic8	NaN	SREBF2	NaN	NaN	0.232839	0.000008	995636.252805	847245.224	166399.0	6557.0
predrem__nrMotif175	Topic8	NaN	EGR2, TBX15, WT1	NaN	ZBTB17	0.23265	0.000107	885000.808851	753197.564	518213.0	4809.0
dbcorrdb__HDAC1__ENCSR000AQF_1__m2	Topic8	HDAC1	HDAC2, REST	NaN	NaN	0.232196	0.000005	899903.703568	766122.214	362401.0	5390.0
transfac_pro__M01915	Topic8	NaN	NaN	MECOM, PRDM13, PRDM16	NaN	0.232033	0.000931	857903.064557	730448.048	820878.0	3150.0
jaspar__MA0373.1	Topic8	NaN	NaN	NaN	NaN	0.231986	0.000018	863673.599672	735385.122	243886.0	6503.0
transfac_pro__M01597	Topic8	ZNF281	CPSF4, SP1, ZBTB17, ZNF148	NaN	NaN	0.23198	0.000167	869096.371076	740005.548	484616.0	4924.0
cisbp__M0669	Topic8	NaN	NaN	E2F2, E2F3	NaN	0.23184	0.000054	824341.196318	701966.014	338545.0	5783.0
scertf__zhao.YML081W	Topic8	NaN	NaN	NaN	NaN	0.231834	0.000056	802003.43248	682947.264	776869.0	3655.0
dbcorrdb__EZH2__ENCSR000ARI_1__m1	Topic8	EZH2	NaN	NaN	NaN	0.231824	0.000041	884581.320767	753271.858	695430.0	4002.0
scertf__zhu.STP2	Topic8	NaN	NaN	NaN	NaN	0.231744	0.000028	881938.918926	751063.596	762139.0	3776.0
hocomoco__E2F1_HUMAN.H11MO.0.A	Topic8	E2F1, E2F4, E2F6, TFDP1	E2F3, E2F7	NaN	SP4	0.231725	0.000196	837854.316354	713530.05	485982.0	4960.0
cisbp__M5854	Topic8	KLF11, SP3	KLF10, KLF13, KLF14, KLF15, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP2, SP4, SP8, SP9, WT1	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.23166	0.000036	817390.732821	696134.536	472753.0	5086.0
transfac_pro__M02058	Topic8	ELK1, ELK3, ELK4, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, GABPA	BCLAF1, ELF1, ELF2, ELF4, ELF5, ETV6, GABPB1, PML, POLR2A, SRF, TAF1	ETV7	ELF3, ETV3L, SPDEF	0.231581	0.000019	984989.065944	838916.046	496439.0	5339.0
cisbp__M0673	Topic8	NaN	NaN	NaN	NaN	0.231396	0.000011	978560.553398	833547.958	147085.0	6590.0
taipale__HINFP1_full_CAACGTCCGCNN_repr	Topic8	HINFP	NaN	NaN	NaN	0.231374	0.000027	956593.154835	814848.5	389571.0	5547.0
transfac_pro__M07527	Topic8	NaN	NaN	NaN	NaN	0.231007	0.000013	962245.956374	819872.288	191842.0	6424.0
transfac_pro__M01593	Topic8	ZFX	CTCF, ESRRA, EZH2, MXI1, POLR2A, RAD21, SMARCA4, ZMIZ1, ZNF274	ZFY	NaN	0.230961	0.00012	830694.182575	707807.322	411480.0	5015.0
flyfactorsurvey__CG9895_SOLEXA_5_FBgn0034810	Topic8	NaN	KLF2, KLF4, KLF5, KLF6, KLF9, KLF14, KLF16, SP1, SP3, SP4, SP8, SP9	KLF3, KLF7, KLF8, KLF12	KLF1, KLF10, KLF11, KLF17, KLF18, SP2, SP6, SP7	0.230873	0.000047	859834.63132	732681.504	652674.0	4134.0
hocomoco__EGR1_MOUSE.H11MO.0.A	Topic8	EGR2	EGR3, EGR4, FOS, IRF1, KLF1, KLF3, KLF6, KLF16, MAZ, PATZ1, SP1, SP2, SP3, SP4, TEAD2, WT1	EGR1	NaN	0.230844	0.000103	908106.609507	773830.696	389895.0	5282.0
dbcorrdb__ATF3__ENCSR000BJY_1__m2	Topic8	ATF3	BHLHE40, CREB1, E2F6, MAX, MYC, NFE2, SIN3A, SRF, USF1, USF2	NaN	NaN	0.23071	0.000012	886555.179423	755536.134	378651.0	5410.0
transfac_pro__M04974	Topic8	NaN	NaN	NaN	NaN	0.230611	0.000013	970424.9565	827067.906	180645.0	6425.0
dbcorrdb__POLR2A__ENCSR000EXX_1__m1	Topic8	ELF1, PHF8, PML, POLR2A	BCLAF1, ELK4, ETS1, GABPA, GTF2F1, HCFC1, MXI1, NRF1, RBBP5, SIN3A, TAF1, ZNF143	NaN	NaN	0.230487	0.000025	945599.602572	805978.886	274037.0	5912.0
cisbp__M1758	Topic8	NaN	NaN	NaN	NaN	0.230313	0.000024	886715.210188	755880.55	599223.0	4878.0
elemento__CTCCCCG	Topic8	NaN	NaN	NaN	NaN	0.230226	0.000491	837610.464759	714064.03	623280.0	3975.0
jaspar__MA1052.1	Topic8	NaN	HCFC1	NaN	NaN	0.230198	0.000011	942704.55302	803672.628	277241.0	5796.0
swissregulon__sacCer__YML081W	Topic8	NaN	NaN	NaN	NaN	0.230054	0.000057	865368.023704	737815.268	555967.0	4494.0
predrem__nrMotif2537	Topic8	NaN	NaN	NaN	NaN	0.230051	0.000027	922466.077039	786499.028	278064.0	5910.0
predrem__nrMotif1089	Topic8	NaN	NaN	NaN	NaN	0.23001	0.001018	862711.955995	735573.438	1081037.0	2573.0
factorbook__ZNF281	Topic8	ZBTB17, ZNF281	MAZ, PATZ1, SP1, SP2, SP3, SP4, VEZF1, WT1	NaN	SP5	0.229968	0.000239	828317.067961	706267.6	735911.0	3734.0
dbcorrdb__SREBF1__ENCSR000EZP_1__m1	Topic8	BRF1, BRF2, CEBPB, CTCF, EGR1, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, RCOR1, SMARCA4, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	CREB1, CUX1, E2F1, E2F6, EGR2, EGR3, EGR4, ELF1, ELK4, ETS1, FOS, GABPA, HCFC1, HIC1, IRF1, JUND, KAT2A, KLF16, KLF3, MAX, MYC, NFYB, NR2C2, PATZ1, PBX3, PHF8, REST, SIN3A, SP1, TAF1, TBX15, TFAP2B, TRIM28, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZFX, ZNF143, ZNF263	NaN	ZBTB17, ZFY, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.229918	0.000008	980136.265036	835745.604	172954.0	6530.0
transfac_pro__M05169	Topic8	NaN	NaN	NaN	NaN	0.229819	0.000011	1021020.834069	870667.144	145927.0	6764.0
transfac_pro__M05107	Topic8	NaN	NaN	NaN	NaN	0.22972	0.000013	994943.29971	848487.878	153932.0	6708.0
elemento__GCCCCCC	Topic8	NaN	NaN	NaN	NaN	0.229436	0.00008	813414.22431	693816.338	752447.0	3530.0
transfac_pro__M01858	Topic8	TFAP2B	EZH2, MXI1, POLR2A, ZMIZ1, ZNF274	NaN	NaN	0.229355	0.000108	776286.037322	662184.586	584288.0	4332.0
hocomoco__ELF1_HUMAN.H11MO.0.A	Topic8	ELF1	EGR1, EHF, ELF2, ELF3, ELF4, ELF5, ELK3, ELK4, ETV6, GABPA, NR2C2, POLR2A	NaN	ETS1	0.229208	0.000016	969984.648468	827496.856	599758.0	5083.0
transfac_pro__M04953	Topic8	SP1	EGR1, EGR2, FOS, IRF1, KLF3, NFYA, NFYB, PATZ1, PBX3, SP2, SP3, SP4, TBX15, VEZF1, ZBTB17, ZNF148, ZNF281	NaN	SP5	0.229195	0.000368	826602.692346	705183.71	907221.0	2933.0
dbcorrdb__SREBF1__ENCSR000DYU_1__m3	Topic8	SREBF1	NaN	NaN	NaN	0.228776	0.000035	828308.915521	706844.686	483728.0	4790.0
cisbp__M0088	Topic8	NaN	NaN	NaN	NaN	0.228704	0.000023	882078.295801	752766.606	571259.0	4619.0
cisbp__M0546	Topic8	NaN	EGR1, EGR2, EGR3, EGR4, KLF11	NaN	WT1	0.228652	0.000069	837201.584542	714494.568	508016.0	4669.0
dbcorrdb__POLR2A__ENCSR000EBG_1__m1	Topic8	ELF1, ETS1, GABPA, HCFC1, PHF8, PML, POLR2A, SIN3A, TAF1	BCLAF1, BRF1, CTCF, E2F6, ELK1, ELK4, EZH2, GABPB1, GTF2F1, HDAC2, KDM5B, MAX, MXI1, NR2C2, RBBP5, XRCC4, ZMIZ1, ZNF143	NaN	FLI1	0.228457	0.000019	949147.294793	810142.166	256841.0	5937.0
cisbp__M1828	Topic8	NaN	NaN	NaN	NaN	0.228185	0.000015	869695.306771	742465.972	649093.0	4680.0
dbcorrdb__CHD2__ENCSR000EED_1__m1	Topic8	BRCA1, CHD2, RCOR1, ZBTB33	ETS1, NR3C1	NaN	NaN	0.228185	0.000011	1004073.621864	857185.868	279716.0	6221.0
transfac_pro__M05035	Topic8	NaN	NaN	NaN	NaN	0.228161	0.000012	1015916.747195	867310.868	132452.0	6852.0
dbcorrdb__TBP__ENCSR000EEL_1__m2	Topic8	TBP	NaN	NaN	NaN	0.227862	0.000016	937622.498928	800635.234	492686.0	5119.0
predrem__nrMotif1714	Topic8	NaN	CTCF, ESRRA, EZH2, FOS, IRF1, KLF5, KLF9, KLF16, MXI1, NFYA, NFYB, PBX3, SMARCA4, SP1, SP2, SP3, SP4, STAT1	NaN	SP6, SP7, SP8, SP9	0.22783	0.000053	892786.201362	762366.32	332443.0	5513.0
dbcorrdb__SIN3A__ENCSR000BGL_1__m1	Topic8	BCLAF1, ELF1, ELK4, ETS1, GABPA, HCFC1, PHF8, POLR2A, SIN3A, TAF1	BRF1, E2F4, E2F6, ELF2, ELK1, EZH2, FOXP2, GABPB1, KDM5A, MAX, MXI1, MYC, NR2C2, PML, RBBP5, RELA, SMARCA4, SREBF1, SRF, UBTF, XRCC4, ZMIZ1, ZNF143, ZNF274	NaN	ERG, FLI1	0.227589	0.000016	970393.170218	828775.038	374368.0	5654.0
dbcorrdb__ATF3__ENCSR000BKC_1__m2	Topic8	ATF3, CREB1	BHLHE40, EZH2, MAX, POLR2A, USF1, USF2	NaN	NaN	0.227495	0.000121	911478.113605	778508.62	522709.0	4759.0
transfac_pro__M04979	Topic8	NaN	NaN	NaN	NaN	0.227479	0.000034	865573.359854	739308.742	515711.0	5127.0
dbcorrdb__ATF3__ENCSR000BKE_1__m2	Topic8	ATF3	BHLHE40, E2F6, MAX, MXI1, MYC, NFE2, POLR2A, TAF1, USF1, USF2, YY1	NaN	NaN	0.227338	0.000063	916277.118648	782692.572	519501.0	4816.0
tfdimers__MD00332	Topic8	PURA, ZBTB14	NaN	NaN	NaN	0.227301	0.001637	793642.597781	677954.42	991204.0	2458.0
taipale__ZNF740_full_NCCCCCCCAC	Topic8	ZNF740	NaN	NaN	NaN	0.22724	0.000389	868752.592107	742147.322	626862.0	4105.0
hocomoco__KLF14_HUMAN.H11MO.0.D	Topic8	KLF13, KLF14, KLF15, SP8, SP9	KLF5, KLF9, KLF16, SP1, SP2, SP3, SP4	KLF17, KLF18	KLF3, KLF6, KLF7, KLF8, KLF10, KLF11, KLF12, SP6, SP7	0.227216	0.000021	968212.955869	827126.654	300355.0	5902.0
dbcorrdb__SUZ12__ENCSR000EXH_1__m5	Topic8	SUZ12	NaN	NaN	NaN	0.227112	0.000325	839996.495146	717645.538	357930.0	5483.0
flyfactorsurvey__CG3065_F1-3_SANGER_2.5_FBgn0034946	Topic8	SP3, SP8, SP9	KLF2, KLF3, KLF4, KLF5, KLF6, KLF9, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, SP1, SP4	KLF17, KLF18	KLF7, KLF8, KLF10, SP2, SP6, SP7	0.227101	0.000014	892615.147522	762605.57	303581.0	5975.0
dbcorrdb__ATF3__ENCSR000BJY_1__m3	Topic8	ATF3	ATF1, USF1	NaN	NaN	0.227069	0.000028	886023.105283	756990.612	490439.0	4663.0
hocomoco__EGR2_MOUSE.H11MO.0.A	Topic8	EGR1	EGR4, KLF6, PATZ1, WT1	EGR2	EGR3	0.226859	0.000343	840658.299584	718336.754	738066.0	3628.0
transfac_pro__M01617	Topic8	NaN	NaN	NaN	NaN	0.226846	0.00024	833362.110579	712108.552	948224.0	2855.0
flyfactorsurvey__hkb_NAR_FBgn0001204	Topic8	NaN	NaN	KLF17, KLF18	NaN	0.226805	0.000037	873534.998361	746457.54	470312.0	5109.0
cisbp__M1807	Topic8	NaN	NaN	NaN	NaN	0.2267	0.000028	844179.216871	721424.704	1173789.0	2278.0
predrem__nrMotif2662	Topic8	NaN	NaN	NaN	NaN	0.226603	0.000072	923901.329088	789607.488	212176.0	6195.0
taipale__TFAP2C_DBD_NSCCNNNGGSN	Topic8	TFAP2A, TFAP2B, TFAP2C	TFAP2E	TFAP2D	NaN	0.226356	0.000623	876735.51885	749426.072	837409.0	3324.0
predrem__nrMotif591	Topic8	NaN	NaN	NaN	NaN	0.226302	0.000035	899635.522254	769029.358	360945.0	5389.0
swissregulon__sacCer__GSM1	Topic8	NaN	NaN	NaN	NaN	0.226276	0.000028	989190.56172	845598.088	530356.0	5235.0
dbcorrdb__EZH2__ENCSR000ARI_1__m2	Topic8	EZH2	NaN	NaN	NaN	0.226151	0.000034	905885.847938	774453.16	425764.0	5105.0
cisbp__M4505	Topic8	ELK1, ELK4, GABPA, GABPB1	BCLAF1, EGR1, ELF1, ELF2, ELF4, ELF5, ELK3, EP300, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, HCFC1, PHF8, PML, POLR2A, SIN3A, SRF, TAF1	NaN	ETV3L, ETV7	0.226012	0.000028	979464.394528	837437.448	714163.0	4452.0
dbcorrdb__TBP__ENCSR000EEL_1__m5	Topic8	TBP	NaN	NaN	NaN	0.225996	0.000064	944911.766738	807903.818	521226.0	4951.0
transfac_pro__M07925	Topic8	NaN	NaN	NaN	NaN	0.225995	0.000386	827916.48695	707872.946	661556.0	4020.0
predrem__nrMotif2548	Topic8	NaN	NaN	NaN	NaN	0.225844	0.000134	935027.854369	799537.244	324101.0	5784.0
hdpi__NNT	Topic8	NNT	NaN	NaN	NaN	0.225833	0.000016	821146.748708	702163.328	255082.0	6232.0
dbcorrdb__POLR2A__ENCSR000EZQ_1__m1	Topic8	POLR2A	E2F4, NFYA, PBX3, SP1, SP2	NaN	NaN	0.225807	0.000034	856443.762577	732359.464	399824.0	5157.0
yetfasco__YLR451W_2135	Topic8	NaN	NaN	NaN	NaN	0.225703	0.000018	857467.166814	733287.46	503686.0	5183.0
transfac_pro__M07039	Topic8	TEAD2	EGR1, SP1, SP2, SP3, SP4, WT1	NaN	NaN	0.225701	0.000158	784069.466272	670519.978	376951.0	5471.0
transfac_pro__M01118	Topic8	WT1	NaN	NaN	NaN	0.225701	0.000566	793232.701551	678356.476	1164648.0	2058.0
predrem__nrMotif632	Topic8	NaN	NaN	NaN	NaN	0.225493	0.000119	888443.338167	759887.998	590754.0	4442.0
taipale_cyt_meth__KLF13_NRCCACGCCCMYN_eDBD	Topic8	KLF13, KLF14, KLF15, KLF16, KLF2, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF4, KLF5, KLF6, KLF9, SP2, SP4	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.22546	0.000026	885703.49212	757562.126	565553.0	4425.0
taipale_cyt_meth__KLF17_NGCCACRCCCWN_eDBD_meth	Topic8	KLF17	KLF4, KLF5	NaN	KLF12, KLF7, KLF8	0.225432	0.000142	851391.330475	728228.114	649149.0	4243.0
transfac_pro__M05455	Topic8	NaN	KLF10, KLF11, SP2, SP5, SP7, SP8, SP9	SP6	KLF14, SP3	0.225364	0.000026	984878.213592	842444.244	141192.0	6613.0
elemento__CCCAGCC	Topic8	NaN	NaN	NaN	NaN	0.225235	0.001182	807426.0029	690717.108	862713.0	2904.0
transfac_public__M00491	Topic8	PATZ1	NaN	NaN	NaN	0.22522	0.000334	834384.772286	713786.644	588070.0	4285.0
transfac_pro__M03174	Topic8	NaN	NaN	NaN	NaN	0.225105	0.000029	923687.897995	790245.156	402582.0	5314.0
cisbp__M0618	Topic8	NaN	NaN	NaN	NaN	0.225067	0.000044	840449.036691	719050.594	819489.0	3555.0
elemento__AGGAGCG	Topic8	NaN	NaN	NaN	NaN	0.224884	0.000231	895783.946161	766490.098	597716.0	4409.0
transfac_pro__M02898	Topic8	SMAD3	NaN	NaN	NaN	0.224867	0.000218	836177.273484	715495.236	731087.0	3750.0
yetfasco__YLR228C_2122	Topic8	NaN	NaN	NaN	NaN	0.224863	0.000027	878666.369941	751854.156	320199.0	6303.0
hocomoco__ZN219_HUMAN.H11MO.0.D	Topic8	ZNF219	NaN	NaN	NaN	0.22478	0.00007	833830.967722	713530.206	753904.0	3575.0
transfac_pro__M09582	Topic8	NaN	NaN	NaN	NaN	0.224773	0.000101	800984.021435	685425.848	435680.0	5269.0
cisbp__M0692	Topic8	ELK1, ELK4, GABPA	BCLAF1, ELF1, ELF2, ELF4, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, GABPB1, PML, SRF, TAF1	ELK3	ETV3L, ETV7	0.224764	0.000035	912773.110074	781091.692	870437.0	3784.0
elemento__CCGAGCG	Topic8	NaN	NaN	NaN	NaN	0.224747	0.000031	935410.494641	800472.726	223084.0	6095.0
hocomoco__EGR2_MOUSE.H11MO.1.A	Topic8	NaN	CUX1, EGR1, EGR4, KLF15, KLF16, MAZ, PATZ1, RCOR1, REST, RREB1, SP1, VEZF1, WT1, ZBTB7B, ZBTB17, ZNF263, ZNF281, ZNF467	EGR2	EGR3, SP5	0.224587	0.001317	830194.249905	710513.454	1192040.0	2239.0
elemento__GCGGCCC	Topic8	NaN	NaN	NaN	NaN	0.224555	0.000029	829263.911739	709733.066	448368.0	4800.0
elemento__CCGCGAG	Topic8	NaN	NaN	NaN	NaN	0.224533	0.00003	934040.598159	799419.488	234221.0	6085.0
elemento__CGCGTCC	Topic8	NaN	NaN	NaN	NaN	0.224238	0.000041	935081.682638	800473.862	270843.0	5987.0
jaspar__MA1053.1	Topic8	NaN	HCFC1	NaN	NaN	0.22407	0.000009	904631.071366	774496.752	316041.0	5465.0
yetfasco__YHR206W_380	Topic8	NaN	NaN	NaN	NaN	0.223974	0.000208	789263.575463	675770.51	662628.0	4064.0
cisbp__M4504	Topic8	EGR1	CTCF, EGR2, EGR3, EGR4, FOS, HDAC2, IRF1, KLF1, KLF16, KLF6, MXI1, NELFE, NFYB, PATZ1, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, TEAD2, WT1, XRCC4	NaN	ZBTB17	0.22395	0.000067	926681.853865	793441.566	425196.0	5242.0
taipale_cyt_meth__KLF13_NRCCACGCCCMYN_eDBD_meth	Topic8	KLF13, KLF14, KLF15, SP3, SP8, SP9	KLF10, KLF11, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP1, SP2	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP4, SP6, SP7	0.223743	0.000044	932362.020426	798419.892	303340.0	5819.0
predrem__nrMotif2459	Topic8	NaN	NaN	NaN	NaN	0.223712	0.000055	962676.650485	824397.036	274615.0	6086.0
transfac_pro__M09054	Topic8	NaN	TAF1	NaN	NaN	0.223552	0.000063	979064.010717	838523.316	356108.0	5788.0
cisbp__M0095	Topic8	NaN	NaN	NaN	NaN	0.223529	0.000027	879389.727651	753169.058	693302.0	4507.0
transfac_pro__M01113	Topic8	NaN	KLF10, KLF14, KLF2, KLF4, KLF5	NaN	KLF11, KLF12, KLF3, KLF6, KLF7, KLF8	0.223275	0.000239	801685.332493	686738.72	1076664.0	2371.0
dbcorrdb__EZH2__ENCSR000ARI_1__m5	Topic8	EZH2	NaN	NaN	NaN	0.223007	0.000072	902478.355189	773223.466	478860.0	4812.0
elemento__GCGCCCC	Topic8	NaN	NaN	NaN	NaN	0.222989	0.000018	846621.562729	725375.782	427427.0	5065.0
hocomoco__GABPA_HUMAN.H11MO.0.A	Topic8	BCLAF1, ELF1, ELK4, GABPA	EGR1, ELF2, ELF5, ELK1, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, GABPB1, HCFC1, NR2C2, PHF8, PML, POLR2A, RELA, SIN3A, SRF, TAF1, ZNF143	NaN	ETV3L, ETV7	0.222851	0.000066	959079.511915	821806.696	773570.0	4109.0
yetfasco__YIL130W_2116	Topic8	NaN	NaN	NaN	NaN	0.222667	0.000018	865178.223301	741439.97	418439.0	5754.0
hocomoco__ZF64A_HUMAN.H11MO.0.D	Topic8	ZFP64	NaN	NaN	NaN	0.22266	0.000219	849183.904426	727736.69	762171.0	3465.0
hocomoco__PATZ1_HUMAN.H11MO.0.C	Topic8	MAZ, PATZ1, WT1, ZNF467	BRF1, CTCF, CUX1, EGR1, EGR2, EGR3, EGR4, HDAC2, IRF1, KLF6, KLF15, KLF16, PBX3, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TBX15, VEZF1, XRCC4, ZBTB7B, ZBTB17, ZNF148, ZNF263, ZNF281, ZNF341	NaN	RELA, SP5	0.222622	0.002706	809456.03417	693709.29	975448.0	2665.0
transfac_pro__M05043	Topic8	NaN	NaN	NaN	NaN	0.22243	0.000028	980852.630816	840709.164	197302.0	6388.0
transfac_pro__M07297	Topic8	MAZ	NaN	NaN	NaN	0.222424	0.001228	784361.365149	672294.874	481409.0	4836.0
cisbp__M1782	Topic8	NaN	NaN	NaN	NaN	0.222342	0.000044	837520.242088	717899.624	727252.0	3971.0
hocomoco__ZBT17_MOUSE.H11MO.0.A	Topic8	NaN	BRF1, BRF2, CUX1, EGR1, EGR2, EGR3, EGR4, EZH2, FOS, HDAC2, KAT2A, KLF15, KLF16, MAZ, NELFE, PATZ1, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, VEZF1, WT1, XRCC4, ZBTB7B, ZNF148, ZNF263, ZNF281, ZNF444, ZNF467	ZBTB17	SP5	0.222168	0.000113	823841.138066	706259.444	627734.0	3941.0
transfac_pro__M01298	Topic8	MECP2	NaN	NaN	NaN	0.222165	0.000167	959410.647333	822481.74	799239.0	4108.0
dbcorrdb__ZBTB33__ENCSR000BHR_1__m1	Topic8	BRCA1, CHD2, RCOR1, ZBTB33	ETS1, NR3C1	NaN	NaN	0.221963	0.000024	1018381.025974	873158.014	373526.0	6058.0
neph__UW.Motif.0280	Topic8	NaN	NaN	NaN	NaN	0.221961	0.001018	830608.34031	712162.904	911145.0	2997.0
yetfasco__YJR127C_575	Topic8	NaN	NaN	NaN	NaN	0.221948	0.000267	829302.428445	711049.612	899253.0	3055.0
jaspar__MA0283.1	Topic8	NaN	NaN	NaN	NaN	0.221895	0.000009	858546.984113	736150.958	238247.0	6120.0
elemento__CGCCTGCGC	Topic8	NaN	NRF1	NaN	NaN	0.221777	0.000038	906506.412054	777337.058	436652.0	4961.0
transfac_public__M00008	Topic8	SP1	NaN	NaN	NaN	0.221694	0.000479	796237.577985	682819.624	712612.0	3916.0
jaspar__MA0062.2	Topic8	ELK1, ELK4, HCFC1	BCLAF1, EGR1, ELF1, ELF2, ELK3, ETS1, ETV1, ETV3, GABPB1, PHF8, PML, POLR2A, SIN3A, SRF, TAF1	GABPA	ERF, ERG, ETV2, ETV3L, ETV4, ETV5, FLI1	0.221655	0.000027	1002934.154331	860097.248	416255.0	5877.0
transfac_pro__M03183	Topic8	NaN	NaN	NaN	NaN	0.221645	0.000026	951671.163788	816140.982	255424.0	6090.0
yetfasco__YLR098C_2120	Topic8	NaN	NaN	NaN	NaN	0.221594	0.000066	845619.407263	725217.952	448554.0	5484.0
transfac_pro__M09541	Topic8	NaN	TAF1	NaN	NaN	0.221515	0.000099	961362.886269	824526.764	1106866.0	3377.0
neph__UW.Motif.0303	Topic8	NaN	NaN	NaN	NaN	0.221462	0.000596	846432.752995	725981.994	1173286.0	2086.0
scertf__morozov.ARO80	Topic8	NaN	NaN	NaN	NaN	0.221407	0.000129	899821.704829	771802.584	579309.0	4841.0
dbcorrdb__STAT1__ENCSR000DZM_1__m1	Topic8	STAT1	SP1	NaN	NaN	0.221397	0.000166	838397.742655	719122.788	503851.0	4749.0
dbcorrdb__TBP__ENCSR000EHA_1__m2	Topic8	TBP	NaN	NaN	NaN	0.221324	0.000054	940922.053335	807102.022	374262.0	5508.0
dbcorrdb__SUZ12__ENCSR000EXH_1__m3	Topic8	SUZ12	NaN	NaN	NaN	0.221171	0.000341	892519.75249	765665.02	623807.0	4412.0
dbcorrdb__GTF2F1__ENCSR000EBP_1__m3	Topic8	GTF2F1	NaN	NaN	NaN	0.221145	0.000065	895970.83306	768639.224	479843.0	5102.0
cisbp__M6252	Topic8	BCLAF1, ELF1, ELK1, ELK4, GABPA, GABPB1	EGR1, ELF2, ELF5, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, HCFC1, NR2C2, PHF8, PML, POLR2A, RELA, SIN3A, SRF, TAF1	NaN	ETV3L, ETV7	0.221017	0.000042	968999.153322	831362.916	647354.0	4674.0
taipale_cyt_meth__ELF1_NATGMGGAAGTN_FL_meth	Topic8	ELF1, ELF2, ELF4	EGR1, ELF5, SPIB	NaN	NaN	0.220985	0.000025	1022460.857773	877250.456	943997.0	4018.0
dbcorrdb__TAF1__ENCSR000BPF_1__m2	Topic8	TAF1	RBBP5	NaN	NaN	0.220842	0.000072	929760.200353	797794.198	358783.0	5551.0
dbcorrdb__ZBTB33__ENCSR000BPZ_1__m1	Topic8	CHD2, ZBTB33	BRCA1, MXI1	NaN	NaN	0.220603	0.00006	954288.137309	818976.41	764657.0	4350.0
transfac_pro__M02933	Topic8	NaN	NaN	ZBTB14	NaN	0.220496	0.000181	914507.901652	784894.968	441742.0	5028.0
cisbp__M1803	Topic8	NaN	NaN	NaN	NaN	0.220414	0.000032	863753.721851	741376.412	524046.0	5257.0
yetfasco__YJL089W_2067	Topic8	NaN	NaN	NaN	NaN	0.220239	0.000466	902048.564368	774339.412	876982.0	3454.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BML_1__m1	Topic8	BCLAF1, ELF1, ETS1, GABPA, HCFC1, PHF8, PML, POLR2A, SIN3A, TAF1, ZNF143	CREB1, E2F6, ELK1, ELK4, ESRRA, ETV1, ETV6, EZH2, FLI1, FOXP2, GABPB1, KDM5B, MAX, MXI1, RBBP5, RELA, THAP1, XRCC4	NaN	ERG	0.220216	0.000014	936963.166057	804323.936	250163.0	6047.0
predrem__nrMotif2467	Topic8	NaN	NaN	NaN	NaN	0.2202	0.000079	954374.759047	819279.316	403603.0	5543.0
scertf__macisaac.IME1	Topic8	NaN	NaN	NaN	NaN	0.220112	0.000041	953109.688942	818243.5	344831.0	5582.0
hocomoco__KLF5_MOUSE.H11MO.0.A	Topic8	NaN	KLF1, KLF2, KLF3, KLF4, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF15, KLF16, KLF17, SP1, SP3	KLF5	NaN	0.220019	0.000284	810221.015257	695618.402	456720.0	4933.0
predrem__nrMotif2613	Topic8	NaN	NaN	NaN	NaN	0.219965	0.000178	914794.797756	785430.072	479532.0	5061.0
transfac_pro__M01837	Topic8	KLF11	NaN	NaN	NaN	0.219782	0.000158	784038.693481	673250.438	765380.0	3551.0
cisbp__M4688	Topic8	ELF1	EHF, ELF2, ELF3, ELF4, ELF5, NR2C2	NaN	ERF, ETV3, ETV3L	0.219658	0.000016	1054836.355945	905860.77	724140.0	5092.0
transfac_pro__M01169	Topic8	IKZF1	NaN	NaN	NaN	0.219471	0.00031	825963.635481	709404.062	464394.0	5343.0
dbcorrdb__TBP__ENCSR000ECB_1__m1	Topic8	TBP	GTF3C2	NaN	NaN	0.219418	0.000152	933180.638507	801519.916	420618.0	5222.0
transfac_pro__M00716	Topic8	ZBTB14	NaN	NaN	NaN	0.219192	0.000022	818880.428571	703456.222	124110.0	7023.0
hdpi__RAB14	Topic8	RAB14	NaN	NaN	NaN	0.219123	0.000171	847086.023704	727721.108	827666.0	3732.0
dbcorrdb__ESRRA__ENCSR000DYQ_1__m5	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MXI1, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SP2, SP4, SREBF1, SREBF2, SUPT20H, XRCC4, ZMIZ1, ZNF274	ATF3, BHLHE40, CREB1, E2F1, E2F6, EGR1, ELF1, ELK1, ETS1, GABPA, HCFC1, HIC1, JUND, KAT2A, KLF3, KLF5, MAX, MAZ, MYC, NR2C2, PBX3, PHF8, POLR3G, RCOR1, SIN3A, SP1, SP3, UBTF, USF1, WRNIP1, WT1, ZBTB7A, ZC3H11A, ZEB1, ZFX	NaN	ZFY	0.218967	0.000025	1022913.526163	878867.038	72656.0	7102.0
transfac_pro__M08867	Topic8	TFAP2A, TFAP2B, TFAP2C, TFAP2D, TFAP2E	NaN	NaN	NaN	0.218887	0.000257	798330.897617	685948.104	727364.0	3788.0
transfac_pro__M01949	Topic8	NaN	NaN	NaN	NaN	0.218864	0.000033	1010367.466146	868150.03	435095.0	5698.0
transfac_pro__M05775	Topic8	ZXDC	ZXDA, ZXDB	NaN	NaN	0.218858	0.001287	871267.384567	748632.644	585053.0	4214.0
predrem__nrMotif1134	Topic8	NaN	NaN	NaN	NaN	0.21884	0.00007	924617.082209	794483.03	326702.0	5732.0
dbcorrdb__HCFC1__ENCSR000ECH_1__m2	Topic8	HCFC1, ZNF143	EGR1, ETS1, SETDB1, SIX5	NaN	NaN	0.218828	0.000366	856590.112974	736036.592	640157.0	4058.0
idmmpmm__h	Topic8	NaN	HES1, HES2	NaN	HES7	0.21861	0.000731	863465.055857	742055.678	1064507.0	2633.0
swissregulon__sacCer__YBR239C	Topic8	NaN	NaN	NaN	NaN	0.218549	0.000022	1038459.006683	892482.052	781032.0	4783.0
dbcorrdb__E2F4__ENCSR000DYY_1__m1	Topic8	E2F4, E2F6, SIN3A	TFDP1, TFDP2	NaN	NaN	0.218534	0.000053	940565.242592	808357.93	506282.0	5104.0
predrem__nrMotif2481	Topic8	NaN	NaN	NaN	NaN	0.218525	0.000978	832711.892573	715669.042	537701.0	4340.0
cisbp__M4870	Topic8	NaN	FOS, IRF1, KLF12, KLF14, KLF15, KLF16, KLF4, KLF5, KLF9, NFYA, NFYB, PBX3, SP8, SP9, STAT1	SP1, SP2, SP3, SP4	E2F4, KLF10, KLF11, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.218301	0.000058	934294.662212	803098.592	309076.0	5782.0
transfac_pro__M05145	Topic8	NaN	NaN	NaN	NaN	0.218097	0.000032	1040502.633842	894519.022	756040.0	4911.0
taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	Topic8	ELF1, GCM1	NaN	NaN	NaN	0.21809	0.000834	860739.223931	739979.95	1082052.0	2722.0
transfac_pro__M05407	Topic8	NaN	NaN	KLF17	NaN	0.218084	0.000048	994683.426428	855135.76	138735.0	6663.0
cisbp__M2125	Topic8	NaN	NaN	NaN	NaN	0.218065	0.000038	973482.188501	836919.97	407456.0	5657.0
transfac_pro__M07052	Topic8	NRF1	E2F6, EGR1, HIST1H2BN, ZSCAN10	NaN	NaN	0.217954	0.00016	927916.418863	797807.678	280713.0	5924.0
transfac_pro__M05171	Topic8	NaN	NaN	NaN	NaN	0.217923	0.000035	1032974.789182	888154.092	278301.0	6445.0
cisbp__M2939	Topic8	TFAP2A, TFAP2C	TFAP2B, TFAP2E	NaN	TFAP2D	0.217769	0.000147	804848.630564	692084.848	1007742.0	2595.0
flyfactorsurvey__luna_SANGER_5_FBgn0040765	Topic8	NaN	NaN	KLF6, KLF7	KLF3, KLF8, KLF12, SP4, SP6, SP7, SP8, SP9	0.217642	0.000399	821885.024965	706796.192	159709.0	6848.0
taipale_cyt_meth__KLF13_NRCCACGCCCMYN_FL_meth	Topic8	KLF13, KLF14, KLF15, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF16, KLF2, KLF4, KLF5, KLF6, KLF9, SP2	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP4, SP6, SP7	0.217564	0.000074	919986.758921	791203.806	453772.0	5017.0
dbcorrdb__POLR2AphosphoS2__ENCSR000EDX_1__m2	Topic8	POLR2A	TAF1	NaN	NaN	0.217372	0.00007	905392.937965	778756.208	378522.0	5522.0
cisbp__M5912	Topic8	TFAP2A, TFAP2B, TFAP2C	TFAP2E	NaN	TFAP2D	0.217359	0.000744	843231.08637	725295.774	920997.0	2907.0
predrem__nrMotif2654	Topic8	NaN	NaN	NaN	NaN	0.217355	0.000266	899657.620477	773832.252	657264.0	4305.0
flyfactorsurvey__l_3_neo38_SANGER_2.5_FBgn0086910	Topic8	NaN	CUX1, MAZ, RCOR1, REST, TBX15, WT1, ZNF460	NaN	ZNF281	0.21735	0.000424	866655.362502	745448.372	636589.0	4156.0
elemento__CCGGGGC	Topic8	NaN	NaN	NaN	NaN	0.217272	0.000017	825468.855882	710060.638	420827.0	5077.0
transfac_pro__M00958	Topic8	NaN	NaN	NaN	NaN	0.217247	0.000432	876931.80179	754341.452	569439.0	4373.0
cisbp__M5513	Topic8	HINFP	NaN	NaN	NaN	0.217191	0.000101	938313.49792	807173.754	349834.0	5655.0
transfac_pro__M01530	Topic8	NaN	NaN	NaN	NaN	0.217159	0.000176	955053.085992	821591.678	736976.0	4415.0
elemento__CGCAGCC	Topic8	NaN	NaN	NaN	NaN	0.217152	0.000435	821426.69802	706641.942	603629.0	3930.0
jaspar__MA0493.1	Topic8	NaN	KLF2, KLF4, KLF5, KLF12	KLF1	KLF3, KLF6, KLF7, KLF8	0.217105	0.000212	912491.039213	785006.972	533883.0	4817.0
predrem__nrMotif1027	Topic8	NaN	NaN	NaN	NaN	0.217078	0.000093	921618.749716	792874.394	322783.0	5715.0
cisbp__M0666	Topic8	NaN	NaN	NaN	NaN	0.216999	0.000038	981846.241331	844734.512	178906.0	6488.0
dbcorrdb__YY1__ENCSR000EXG_1__m2	Topic8	YY1	ATF3, POLR2A	NaN	NaN	0.216957	0.000044	950196.072752	817527.812	264401.0	6166.0
cisbp__M6146	Topic8	TFAP2D	NaN	NaN	NaN	0.21676	0.000033	964951.775564	830336.852	234565.0	6144.0
taipale_cyt_meth__KLF13_NRCCACGCCCMYN_FL_repr	Topic8	KLF13, KLF14, KLF15, KLF2, SP1, SP3, SP8, SP9	KLF10, KLF11, KLF16, KLF4, KLF5, KLF6, KLF9, SP2, SP4	NaN	KLF12, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.216667	0.00005	918967.494137	790818.6	430384.0	5175.0
cisbp__M6481	Topic8	SP2	NFYA, NFYB, SP1, SP3, SP4	NaN	NaN	0.216524	0.000466	821918.803682	707373.396	914368.0	2860.0
cisbp__M0517	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.21636	0.000128	811427.348128	698423.196	664458.0	3988.0
transfac_pro__M02039	Topic8	ELK4, ERF, ERG, ETS1, ETV1, ETV2, ETV3, ETV4, FLI1	BCLAF1, ELF1, ELF2, ELF4, ELK1, ELK3, ETS2, ETV5, ETV6, FEV, GABPB1, PML, POLR2A, SRF, TAF1	GABPA	ETV3L, ETV7	0.216331	0.000097	942619.353675	811361.336	721961.0	4472.0
dbcorrdb__EZH2__ENCSR000ARH_1__m2	Topic8	EZH2	NaN	NaN	NaN	0.216329	0.000369	840446.548228	723416.534	781593.0	3471.0
hocomoco__THAP1_HUMAN.H11MO.0.C	Topic8	THAP1	KDM5A, MYC, NR3C1, REST, TAF1, YY1, ZFP42	NaN	NaN	0.216286	0.000905	835621.566511	719284.898	656113.0	3782.0
dbcorrdb__EZH2__ENCSR000ARR_1__m3	Topic8	EZH2	MXI1, POLR2A, SREBF2, ZMIZ1	NaN	NaN	0.216235	0.000053	926197.690707	797279.104	262959.0	5864.0
transfac_pro__M01520	Topic8	NaN	NaN	NaN	NaN	0.216204	0.000048	997316.151935	858517.334	226504.0	6364.0
cisbp__M0006	Topic8	NaN	NaN	NaN	NaN	0.215908	0.000266	818959.904552	705127.896	1007517.0	2730.0
transfac_pro__M05479	Topic8	ZNF580	NaN	NaN	NaN	0.215673	0.000055	984074.153701	847429.766	169939.0	6494.0
transfac_pro__M04797	Topic8	EGR1	EGR2, EGR3, EGR4, WT1	NaN	SP4	0.215031	0.000044	975270.056992	840222.36	305634.0	5986.0
dbcorrdb__STAT1__ENCSR000DZM_1__m6	Topic8	STAT1	BHLHE40, MAX, MYC, USF1	NaN	NaN	0.214375	0.000362	853704.316732	735824.232	501220.0	4891.0
elemento__TCGCCGC	Topic8	NaN	NaN	NaN	NaN	0.214235	0.000051	930691.150927	802258.494	252363.0	6114.0
predrem__nrMotif2096	Topic8	NaN	KLF3, KLF6	NaN	NaN	0.213945	0.000275	912220.173749	786494.836	545783.0	4677.0
dbcorrdb__SIN3A__ENCSR000BOW_1__m4	Topic8	SIN3A	CREB1	NaN	NaN	0.213911	0.000432	834921.658555	719866.964	543896.0	4346.0
transfac_pro__M09079	Topic8	TAF1	ELK1, GABPA, POLR2A	NaN	NaN	0.213875	0.000069	1013249.138066	873641.9	128769.0	6891.0
taipale_cyt_meth__KLF5_NMCACGCCCN_eDBD_meth	Topic8	KLF5	KLF12, KLF16, KLF17, KLF2, KLF3, KLF4, KLF6, SP3, SP8, SP9	NaN	KLF10, KLF11, KLF18, KLF7, KLF8, SP4, SP6, SP7	0.213828	0.000715	832947.827891	718206.418	1116747.0	2325.0
transfac_pro__M05386	Topic8	KLF17	KLF2	NaN	NaN	0.213828	0.000068	984417.45215	848810.602	148462.0	6557.0
transfac_pro__M01849	Topic8	NaN	NaN	NaN	NaN	0.213766	0.000533	865947.38608	746692.086	650467.0	4235.0
predrem__nrMotif1573	Topic8	NaN	NaN	NaN	NaN	0.213654	0.000306	919388.486067	792834.888	762566.0	4113.0
dbcorrdb__POLR2A__ENCSR000EYW_1__m2	Topic8	POLR2A	GABPA	NaN	NaN	0.213643	0.000245	894932.520867	771751.108	474144.0	5073.0
elemento__AGCGGCG	Topic8	NaN	NaN	NaN	NaN	0.213532	0.000015	876793.730677	756167.256	255953.0	5889.0
predrem__nrMotif2274	Topic8	NaN	NaN	NaN	NaN	0.21347	0.000862	924962.327575	797743.364	422827.0	5184.0
taipale__TFAP2B_DBD_NSCCNNNGGSN	Topic8	TFAP2A, TFAP2B, TFAP2C	TFAP2E	NaN	TFAP2D	0.213462	0.000912	908942.146135	783931.09	716974.0	4096.0
yetfasco__YKL222C_2192	Topic8	NaN	NaN	NaN	NaN	0.213213	0.000052	865384.82726	746492.856	452459.0	5630.0
cisbp__M0014	Topic8	NaN	NaN	NaN	NaN	0.212965	0.000432	838813.065313	723696.154	560039.0	4812.0
transfac_pro__M08996	Topic8	NaN	EGR2, EGR3, EGR4, SP1, TEAD2, WT1	EGR1	SP4, SP6, SP7, SP8, SP9	0.212843	0.000308	877953.547724	757529.146	618955.0	4203.0
transfac_pro__M04934	Topic8	NR2C2	NaN	NaN	NaN	0.212842	0.000086	888982.838356	767046.33	594747.0	4371.0
cisbp__M1903	Topic8	BCLAF1, ELF1, ELK1, ELK4, GABPA, GABPB1	EGR1, ELF2, ELF4, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, HCFC1, PHF8, PML, POLR2A, SIN3A, SRF, TAF1	NaN	ETV3L, ETV6, ETV7	0.212807	0.000054	965542.390619	833124.602	718403.0	4435.0
transfac_pro__M07348	Topic8	TFAP2A, TFAP2B, TFAP2C, TFAP2D, TFAP2E	EZH2, ZNF274	NaN	NaN	0.212729	0.000179	791578.987013	683056.44	668953.0	4029.0
hocomoco__EGR2_HUMAN.H11MO.1.A	Topic8	EGR1, EGR2	EGR3, EGR4, KLF1, KLF6, KLF16, PATZ1, TBX15, WT1, ZBTB17, ZNF148, ZNF281	NaN	NaN	0.212721	0.000798	830641.107679	716766.884	707469.0	3818.0
swissregulon__sacCer__RDS2	Topic8	NaN	NaN	NaN	NaN	0.212595	0.000087	991917.326693	856008.094	586947.0	5085.0
dbcorrdb__E2F6__ENCSR000EVK_1__m1	Topic8	E2F6	BRF1, CEBPB, CTCF, E2F1, E2F4, EZH2, HDAC2, MAZ, NELFE, POLR2A, RAD21, RBBP5, SMARCA4, SREBF1, SREBF2, SUPT20H, TAF1, XRCC4, ZNF274	NaN	E2F3	0.212473	0.000461	912036.540789	787139.27	342940.0	5444.0
dbcorrdb__RXRA__ENCSR000BJD_1__m2	Topic8	RXRA	CTCF, CTCFL, MAZ, RAD21, SMC3, ZNF143	NaN	NaN	0.212372	0.000694	858007.234144	740560.54	640193.0	4055.0
predrem__nrMotif852	Topic8	NaN	NaN	NaN	NaN	0.212071	0.000292	911149.881856	786593.276	320215.0	5682.0
transfac_pro__M05105	Topic8	NaN	NaN	NaN	NaN	0.212031	0.000059	1019798.361241	880413.448	116209.0	6931.0
transfac_pro__M01857	Topic8	TFAP2A	TFAP2B, TFAP2C, TFAP2D, TFAP2E	NaN	NaN	0.211691	0.00079	779908.609507	673470.332	714618.0	3797.0
scertf__harbison.MSN2	Topic8	NaN	NaN	MECOM, PRDM13, PRDM16	NaN	0.211569	0.000584	882887.138192	762459.388	982174.0	2929.0
predrem__nrMotif2358	Topic8	NaN	NaN	NaN	NaN	0.211468	0.000059	932295.354306	805184.376	181756.0	6450.0
dbcorrdb__POLR2A__ENCSR000FAW_1__m1	Topic8	GABPA, POLR2A	ELF1, ELK1, ELK4, ETS1, HCFC1, MYC, NRF1, PHF8, PML, SIN3A, SRF, TAF1, ZNF143	NaN	NaN	0.211365	0.000074	959742.879586	828948.958	277749.0	5928.0
transfac_pro__M05012	Topic8	NaN	NaN	NaN	NaN	0.211364	0.000032	1031496.795108	890924.392	158761.0	6842.0
elemento__CCCCCTC	Topic8	NaN	NaN	NaN	NaN	0.211323	0.001019	828675.307023	715764.032	796560.0	3324.0
elemento__GCCACGCCC	Topic8	NaN	KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF5, KLF6, KLF9, SP1, SP3, SP4, SP8, SP9	NaN	KLF10, KLF17, KLF18, KLF3, KLF7, KLF8, SP6, SP7	0.21126	0.000239	862537.756273	745044.876	678543.0	3828.0
dbcorrdb__ELF1__ENCSR000BMZ_1__m1	Topic8	BCLAF1, ELF1, ELF2, ELK4, GABPA, HCFC1, PHF8, POLR2A, SIN3A	EGR1, EHF, ELF3, ELF4, ELF5, ELK1, ELK3, ETS1, ETV2, ETV6, GABPB1, IRF1, MYC, PML, RBBP5, RELA, SRF, TAF1, ZNF143	NaN	ERF, ERG, ETV3, ETV3L, FLI1	0.211006	0.000054	981216.830034	847707.132	438789.0	5668.0
flyfactorsurvey__sr_SANGER_5_FBgn0003499	Topic8	EGR1	KLF11, SP1	EGR2, EGR3, EGR4	WT1	0.21075	0.001544	845458.132896	730550.222	929034.0	2910.0
elemento__CGCCAGC	Topic8	NaN	NaN	NaN	NaN	0.210748	0.002639	849269.061026	733844.244	589840.0	4104.0
elemento__CACGCCC	Topic8	NaN	KLF14, KLF9, SP8	NaN	KLF17, KLF18	0.210714	0.000129	866054.003152	748365.358	537773.0	4472.0
transfac_pro__M09068	Topic8	NaN	TAF1	NaN	NaN	0.210337	0.000242	926369.596898	800693.9	422964.0	5236.0
swissregulon__sacCer__YLL054C	Topic8	NaN	NaN	NaN	NaN	0.21032	0.000083	941803.179927	814043.204	375400.0	5531.0
predrem__nrMotif2277	Topic8	NaN	NaN	NaN	NaN	0.210255	0.000215	931412.520741	805098.266	202659.0	6326.0
predrem__nrMotif2374	Topic8	NaN	NaN	NaN	NaN	0.210208	0.000179	908646.515067	785445.598	330214.0	5720.0
dbcorrdb__ZC3H11A__ENCSR000EFR_1__m2	Topic8	ZC3H11A	BRF1, BRF2, CTCF, ESRRA, EZH2, MXI1, NELFE, POLR2A, SMARCA4, SREBF1, ZMIZ1	NaN	NaN	0.210177	0.00097	800426.463245	691913.656	628394.0	3828.0
predrem__nrMotif2130	Topic8	NaN	NaN	NaN	NaN	0.210147	0.000027	945077.368302	816971.092	294234.0	5913.0
cisbp__M2271	Topic8	NaN	NaN	E2F3	NaN	0.209974	0.000916	909288.209305	786127.79	475151.0	4895.0
dbcorrdb__CHD2__ENCSR000DZR_1__m1	Topic8	CHD2, ZBTB33	BRCA1, ETS1, RCOR1	NaN	NaN	0.209902	0.000106	912863.354684	789258.012	371505.0	5469.0
transfac_pro__M03204	Topic8	NaN	NaN	NaN	NaN	0.209836	0.000166	946886.76056	818712.028	344642.0	5651.0
transfac_pro__M05146	Topic8	NaN	NaN	NaN	NaN	0.209833	0.00004	1038694.329341	898094.0	196645.0	6753.0
predrem__nrMotif1366	Topic8	NaN	NaN	NaN	NaN	0.209738	0.00007	960558.238305	830589.374	240026.0	6138.0
cisbp__M0576	Topic8	NaN	NaN	NaN	NaN	0.20973	0.000162	853074.648468	737652.918	670037.0	4274.0
transfac_pro__M01972	Topic8	EGR1, EGR2, EGR3, EGR4	NaN	NaN	WT1	0.209706	0.000414	881916.226958	762604.77	732631.0	3877.0
bergman__h	Topic8	NaN	NaN	NaN	NaN	0.209705	0.000371	880691.977683	761546.524	448254.0	5077.0
transfac_pro__M00952	Topic8	NaN	NaN	NaN	NaN	0.209649	0.001809	855820.369815	740068.634	1025209.0	2830.0
transfac_public__M00469	Topic8	TFAP2A, TFAP2C	TFAP2B, TFAP2D, TFAP2E	NaN	NaN	0.209624	0.000718	806858.872399	697741.204	770134.0	3664.0
cisbp__M0082	Topic8	TFAP2B	TFAP2C, TFAP2E	TFAP2A	TFAP2D	0.20946	0.000711	835551.405119	722635.964	986882.0	2823.0
scertf__badis.YNR063W	Topic8	NaN	NaN	NaN	NaN	0.209371	0.00027	917741.72866	793768.104	597911.0	4829.0
predrem__nrMotif2348	Topic8	NaN	BRF1, CTCF, EGR1, ESRRA, EZH2, HCFC1, HDAC2, MXI1, NELFE, PHF8, POLR2A, RAD21, SMARCA4, SREBF1, SREBF2, TAF1, XRCC4, ZMIZ1	NaN	NaN	0.208964	0.000046	982376.347497	849910.756	144713.0	6610.0
elemento__CCCCTCCC	Topic8	NaN	PATZ1, ZNF281, ZNF467	NaN	NaN	0.208913	0.002695	808035.906065	699103.744	506194.0	4613.0
dbcorrdb__POLR2AphosphoS2__ENCSR000EGF_1__m3	Topic8	POLR2A	NaN	NaN	NaN	0.208888	0.001826	873561.426932	755808.938	735942.0	3774.0
transfac_pro__M03168	Topic8	NaN	NaN	NaN	NaN	0.208827	0.000161	933381.574329	807599.31	328512.0	5611.0
elemento__GGCGCCC	Topic8	NaN	NaN	NaN	NaN	0.208767	0.000044	842047.090657	728603.334	378132.0	5316.0
transfac_pro__M04866	Topic8	HDAC2	NaN	NaN	NaN	0.208742	0.000073	885880.128105	766544.724	290316.0	5977.0
dbcorrdb__RBBP5__ENCSR000AQC_1__m1	Topic8	RBBP5	NaN	NaN	NaN	0.208728	0.000309	858375.451898	742752.06	559404.0	4340.0
swissregulon__sacCer__GAL4	Topic8	NaN	NaN	NaN	NaN	0.208699	0.000056	1029956.548859	891239.224	421227.0	5993.0
transfac_pro__M09581	Topic8	NaN	NaN	NaN	NaN	0.208694	0.000197	906699.968982	784585.736	628210.0	4332.0
hocomoco__ZN281_HUMAN.H11MO.0.A	Topic8	ZBTB17, ZNF281	EGR2, MAZ, PATZ1, SP1, VEZF1, WT1, ZNF148, ZNF467	NaN	SP5	0.208515	0.001277	867230.080066	750524.728	896491.0	3368.0
dbcorrdb__ATF3__ENCSR000BNU_1__m4	Topic8	ATF3	NaN	NaN	NaN	0.208506	0.000253	857428.556424	742046.942	633649.0	4119.0
dbcorrdb__EGR1__ENCSR000BRG_1__m1	Topic8	EGR1, SREBF1, SREBF2	BRF1, BRF2, CEBPB, CTCF, CUX1, EGR2, EGR3, EGR4, ESRRA, EZH2, HDAC2, KAT2A, KLF1, KLF16, KLF6, MAZ, MXI1, MYC, NELFE, PATZ1, PBX3, POLR2A, RAD21, RBBP5, RCOR1, REST, SMARCA4, SP1, SP2, SP3, SP4, SUPT20H, TBX15, TEAD2, WT1, XRCC4, ZBTB7B, ZMIZ1, ZNF274, ZNF467	NaN	ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.208449	0.000199	909210.893078	786892.272	386729.0	5210.0
transfac_pro__M01122	Topic8	ZNF219	SP1, TBX15	NaN	NaN	0.208235	0.000821	878065.710251	760049.708	513633.0	4546.0
predrem__nrMotif1076	Topic8	NaN	NaN	NaN	NaN	0.208201	0.000396	920769.772286	797032.914	416416.0	5353.0
tfdimers__MD00418	Topic8	MTF1, MZF1	NaN	NaN	NaN	0.208043	0.000907	893574.036439	773576.792	613330.0	4311.0
flyfactorsurvey__CG3065_F1-3_SOLEXA_2.5_FBgn0034946	Topic8	SP8, SP9	KLF5, KLF13, KLF14, KLF15, KLF16, SP1, SP3, SP4	KLF17, KLF18	KLF3, KLF6, KLF7, KLF8, KLF10, KLF11, KLF12, SP6, SP7	0.208029	0.0001	949522.224057	822019.844	202004.0	6645.0
transfac_pro__M05042	Topic8	NaN	NaN	NaN	NaN	0.207992	0.000042	1025348.406758	887686.786	334043.0	6237.0
transfac_pro__M05052	Topic8	NaN	NaN	NaN	NaN	0.207904	0.000075	981706.937965	849956.15	218735.0	6315.0
transfac_pro__M05050	Topic8	NaN	NaN	NaN	NaN	0.207746	0.000087	996960.898752	863257.634	415378.0	5799.0
dbcorrdb__RBBP5__ENCSR000AQC_1__m3	Topic8	RBBP5	NaN	NaN	NaN	0.207645	0.000517	841509.352793	728704.534	566182.0	4284.0
dbcorrdb__BCLAF1__ENCSR000BKH_1__m1	Topic8	BCLAF1	ELF1, ELK1, ELK4, ETV1, GABPA, GABPB1	NaN	FLI1	0.207598	0.000139	945111.598411	818445.854	301047.0	6229.0
cisbp__M0093	Topic8	NaN	NaN	NaN	NaN	0.207509	0.000136	961666.294666	832832.88	410667.0	5492.0
transfac_pro__M03806	Topic8	ZBTB7C	NaN	NaN	NaN	0.207384	0.001377	784590.339175	679538.718	908713.0	2835.0
cisbp__M1824	Topic8	NaN	NaN	NaN	NaN	0.207353	0.00007	970668.668894	840720.114	493643.0	5438.0
elemento__CCGGAGC	Topic8	NaN	NaN	NaN	NaN	0.20735	0.000309	873830.0986	756847.796	465956.0	4799.0
dbcorrdb__CHD2__ENCSR000ECP_1__m1	Topic8	BRCA1, CHD2, ZBTB33	RCOR1	NaN	NaN	0.207311	0.00005	912719.341571	790552.062	202778.0	6407.0
transfac_pro__M00807	Topic8	EGR1, EGR2, EGR3	NaN	NaN	NaN	0.207299	0.000816	789232.40638	683599.198	828822.0	3257.0
dbcorrdb__GABPA__ENCSR000BLO_1__m1	Topic8	BCLAF1, ELF1, ELK1, ELK4, ETS1, GABPA, GABPB1, HCFC1, PHF8, PML, POLR2A, RBBP5, SIN3A	CREB1, E2F4, E2F6, EGR1, ELF2, ELF4, ELK3, ERF, ERG, ESRRA, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, EZH2, FEV, FLI1, FOXP2, IRF1, KDM5A, KDM5B, MAX, MXI1, MYC, NR2C2, RELA, SMARCA4, SREBF1, SREBF2, SRF, SUPT20H, TAF1, UBTF, XRCC4, ZMIZ1, ZNF143, ZNF274	NaN	ETV3L, ETV7	0.20727	0.000044	956370.496533	828384.14	462168.0	5445.0
jaspar__MA0632.1	Topic8	NaN	NaN	TCFL5	BHLHE40	0.207093	0.000913	863206.086244	747778.936	837921.0	3633.0
jaspar__MA1060.1	Topic8	NaN	NaN	NaN	NaN	0.207088	0.000084	979756.426428	848747.228	649149.0	4720.0
dbcorrdb__POLR2AphosphoS5__ENCSR000BPA_1__m2	Topic8	NaN	NaN	NaN	NaN	0.207057	0.000082	899836.568529	779530.722	333102.0	5772.0
cisbp__M1666	Topic8	NaN	NaN	NaN	NaN	0.207048	0.000309	858433.577481	743667.684	702328.0	4062.0
elemento__CCCTCCCC	Topic8	NaN	NaN	NaN	ZNF281	0.207046	0.003473	803388.660446	695982.846	534963.0	4586.0
dbcorrdb__SAP30__ENCSR000AQJ_1__m3	Topic8	SAP30	SIN3A	NaN	NaN	0.20701	0.000227	895232.134157	775567.226	367751.0	5448.0
cisbp__M0568	Topic8	NaN	NaN	NaN	NaN	0.206876	0.002798	803610.129366	696256.932	775396.0	3552.0
elemento__CCCTCCCCC	Topic8	NaN	MAZ, ZBTB17, ZNF148, ZNF281	NaN	NaN	0.206813	0.001917	831476.123061	720431.538	859971.0	3015.0
transfac_pro__M01096	Topic8	NaN	NaN	NaN	NaN	0.206723	0.000709	830713.371958	719815.86	772427.0	3899.0
transfac_pro__M09574	Topic8	NaN	NaN	NaN	NaN	0.206601	0.000237	895597.599924	776103.59	490212.0	4838.0
flyfactorsurvey__Eip74EF_SANGER_5_FBgn0000567	Topic8	NaN	EHF, ELF3, ELF5	ELF1, ELF2, ELF4	ERF, ETV3, ETV3L	0.206582	0.00007	1005737.371832	871559.776	594577.0	5065.0
cisbp__M6190	Topic8	E2F1, E2F4	E2F3, TFDP1	NaN	NaN	0.206525	0.002674	852386.542933	738697.304	1272977.0	1945.0
predrem__nrMotif1778	Topic8	NaN	EGR1, EGR2, EGR3, EGR4, EZH2, POLR2A, SMARCA4	NaN	NaN	0.206518	0.000464	888428.130248	769934.97	431414.0	5076.0
scertf__zhu.RDS1	Topic8	NaN	NaN	NaN	NaN	0.206515	0.000092	974479.283697	844511.276	286090.0	6101.0
dbcorrdb__E2F6__ENCSR000BLI_1__m1	Topic8	E2F1, E2F6, XRCC4	BRF1, BRF2, CEBPB, CTCF, E2F4, EGR1, ELF1, ELK4, ESRRA, EZH2, GABPA, HDAC2, MAX, MAZ, MXI1, MYC, NELFE, POLR2A, RAD21, RBBP5, RXRA, SMARCA4, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, TFAP2B, ZMIZ1, ZNF274	NaN	E2F3	0.206375	0.000282	910269.9043	788941.936	379909.0	5212.0
transfac_pro__M01791	Topic8	NaN	NaN	NaN	NaN	0.206332	0.002441	809733.203631	701826.534	927139.0	2837.0
hocomoco__CTCFL_HUMAN.H11MO.0.A	Topic8	CTCF, CTCFL, MAZ, RAD21, RXRA, SMC3, ZNF143	ARID3A, ZBTB7A, ZC3H11A	NaN	REST, ZFP64	0.206242	0.000611	910196.019796	788950.572	467626.0	4898.0
cisbp__M1553	Topic8	NaN	GMEB1, GMEB2	NaN	NaN	0.206201	0.003338	870246.86786	754344.474	940545.0	3016.0
predrem__nrMotif1367	Topic8	NaN	NaN	NaN	NaN	0.206139	0.000358	915954.056865	793998.396	455913.0	5185.0
predrem__nrMotif1621	Topic8	NaN	NaN	NaN	NaN	0.206136	0.000768	917171.455302	795055.342	376290.0	5471.0
hocomoco__GABPA_MOUSE.H11MO.0.A	Topic8	BCLAF1, ELF1, ELK1, ELK4	EGR1, ELF2, ELF5, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, ETV6, FEV, FLI1, GABPB1, HCFC1, NR2C2, PHF8, PML, POLR2A, RELA, SIN3A, SRF, TAF1, ZNF143	GABPA	ETV3L, ETV7	0.20612	0.000165	977611.386836	847457.296	667937.0	4613.0
cisbp__M6143	Topic8	TFAP2A, TFAP2C	TFAP2B, TFAP2E	NaN	NaN	0.20608	0.001628	818447.595637	709503.582	1050471.0	2420.0
swissregulon__sacCer__GAL80	Topic8	NaN	NaN	NaN	NaN	0.205945	0.000243	896646.090909	777366.05	463740.0	5032.0
predrem__nrMotif1979	Topic8	NaN	NaN	NaN	NaN	0.20587	0.000296	882804.338545	765404.966	628267.0	3976.0
cisbp__M0605	Topic8	NaN	NaN	NaN	NaN	0.205823	0.00021	888595.025722	770450.742	863284.0	3565.0
hdpi__PRNP	Topic8	PRNP	NaN	NaN	NaN	0.205806	0.000101	902837.66549	782809.018	864495.0	3852.0
dbcorrdb__GTF2F1__ENCSR000ECZ_1__m4	Topic8	GTF2F1	NaN	NaN	NaN	0.20577	0.000584	865615.931787	750554.582	857216.0	3298.0
cisbp__M5921	Topic8	TFAP2A, TFAP2B, TFAP2C	TFAP2E	TFAP2D	NaN	0.205676	0.00236	856718.813769	742888.402	888556.0	3126.0
yetfasco__YHR206W_583	Topic8	NaN	NaN	NaN	NaN	0.20563	0.007143	827088.177405	717217.822	895609.0	2725.0
swissregulon__hs__MAZ.p2	Topic8	MAZ	NaN	NaN	ZBTB17	0.20562	0.000701	877941.808977	761321.224	281167.0	5990.0
cisbp__M5098	Topic8	NaN	KLF12, KLF14, KLF2, KLF3, KLF4, KLF5, KLF9	KLF6, KLF7, KLF8	KLF17, KLF18, SP1, SP2, SP3, SP4, SP6, SP7, SP8, SP9	0.205602	0.00019	844704.523767	732508.252	767435.0	3602.0
cisbp__M4209	Topic8	NaN	NaN	NaN	NaN	0.205428	0.000098	1010497.342454	876385.29	417540.0	5774.0
dbcorrdb__BRCA1__ENCSR000EDB_1__m1	Topic8	BRCA1	ATF1, ATF3, CHD2, RCOR1, ZBTB33	NaN	NaN	0.205378	0.000204	979110.442063	849193.826	543624.0	5219.0
dbcorrdb__NR2C2__ENCSR000EWH_1__m2	Topic8	NR2C2	NaN	NaN	NaN	0.205338	0.000354	849957.024965	737197.914	472985.0	4891.0
taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	Topic8	GCM1, SPDEF	NaN	NaN	NaN	0.205264	0.000187	1028659.407263	892238.382	1095198.0	3706.0
hocomoco__ELK4_HUMAN.H11MO.0.A	Topic8	ELF1, ELK1, ELK4, GABPA	BCLAF1, EGR1, ELF2, ELF4, ELK3, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, GABPB1, HCFC1, PHF8, PML, POLR2A, SIN3A, SRF, TAF1	NaN	ETV3L, ETV6, ETV7	0.205252	0.000254	975494.871517	846131.642	1090333.0	3302.0
taipale__ETV5_DBD_ACCGGAWGYN	Topic8	ELK3, ELK4, ERF, ERG, ETS1, ETS2, ETV1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, GABPA	BCLAF1, ELF1, ELK1, ETV6, GABPB1, SPDEF, SRF, TAF1	NaN	ELF2, ETV3L, ETV7	0.205243	0.000266	926436.558568	803584.442	885554.0	3707.0
transfac_pro__M05000	Topic8	NaN	NaN	NaN	NaN	0.205234	0.00011	1014928.604842	880346.97	310775.0	6273.0
cisbp__M1726	Topic8	NaN	NaN	NaN	NaN	0.205044	0.000341	885022.725886	767767.976	375747.0	5397.0
transfac_pro__M05021	Topic8	NaN	NaN	NaN	NaN	0.204964	0.000109	1004214.727399	871217.096	180454.0	6521.0
dbcorrdb__SREBF1__ENCSR000EEO_1__m3	Topic8	ATF3, SREBF1	ATF1, BHLHE40, E2F6, MAX, MYC, NFE2, USF1, USF2	NaN	NaN	0.204941	0.000485	884483.780482	767355.284	638583.0	4141.0
elemento__AGGCGCG	Topic8	NaN	NaN	NaN	NaN	0.204933	0.000135	922425.0145	800276.296	269031.0	5873.0
yetfasco__YIL130W_807	Topic8	NaN	NaN	NaN	NaN	0.204915	0.000162	949396.304501	823686.678	329806.0	5751.0
elemento__CCCGGAA	Topic8	NaN	ELF1	NaN	ELF2, ELF4	0.204746	0.000271	914705.567646	793682.068	528829.0	4964.0
transfac_pro__M09022	Topic8	NaN	ELK1, GABPA, KDM5A, POLR2A, TAF1, YY1	NaN	NaN	0.204691	0.000106	988994.961291	858175.202	177904.0	6546.0
transfac_pro__M07627	Topic8	NaN	NaN	TFAP2A, TFAP2B, TFAP2C, TFAP2D, TFAP2E	NaN	0.204327	0.001347	858353.403606	745002.326	801278.0	3627.0
hocomoco__KAISO_HUMAN.H11MO.1.A	Topic8	ZBTB33	BRCA1, CHD2, ETS1, NR3C1, RCOR1	NaN	NaN	0.204314	0.000128	928954.759299	806287.45	528922.0	5071.0
taipale_cyt_meth__TFAP2B_NGCCNNNGGCN_eDBD	Topic8	TFAP2A, TFAP2B, TFAP2C, TFAP2E	NaN	NaN	TFAP2D	0.20429	0.001325	822251.039339	713685.562	957330.0	2753.0
transfac_pro__M01816	Topic8	ZNF148	NaN	NaN	NaN	0.204286	0.00218	808877.779599	702080.236	680422.0	3970.0
hocomoco__TBX15_HUMAN.H11MO.0.D	Topic8	CUX1, MAZ, RCOR1, REST, TBX15	BRF1, BRF2, CEBPB, CPSF4, CTCF, EGR1, EGR2, HDAC2, KLF6, KLF15, KLF16, NELFE, PATZ1, PAX4, PBX3, RAD21, RBBP5, RREB1, SMARCA4, SP1, SP2, SP3, SP4, SREBF1, SREBF2, SUPT20H, VEZF1, WT1, XRCC4, ZBTB7B, ZNF148, ZNF219, ZNF444, ZNF460, ZNF467, ZNF740	NaN	SP5, ZNF16, ZNF23, ZNF84, ZNF189, ZNF281, ZNF429, ZNF471, ZNF502, ZNF607	0.204082	0.001115	852963.008826	740449.618	427581.0	5044.0
transfac_pro__M07475	Topic8	NaN	NaN	TBX5	NaN	0.204021	0.000326	839814.72349	729066.088	833392.0	3495.0
transfac_pro__M01073	Topic8	HIC1	ZBTB7A	NaN	NaN	0.203923	0.003103	819523.48922	711499.258	746878.0	3491.0
transfac_pro__M07534	Topic8	NaN	NaN	NaN	NaN	0.203895	0.000335	824100.620098	715486.796	660206.0	4114.0
cisbp__M6552	Topic8	ZNF148	CUX1, EGR1, EGR2, EGR3, EGR4, KLF16, MAZ, PATZ1, PAX4, RCOR1, REST, SP1, TBX15, VEZF1, ZBTB17, ZNF281, ZNF467	NaN	SP5, ZNF16, ZNF189, ZNF23, ZNF429, ZNF471, ZNF502, ZNF607, ZNF84	0.203822	0.002203	827598.13214	718559.888	766891.0	3403.0
dbcorrdb__POLR2A__ENCSR000EXO_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.203771	0.000197	931380.585298	808697.152	478977.0	4993.0
predrem__nrMotif1294	Topic8	NaN	KLF2, KLF5, KLF6, KLF9, KLF13, KLF14, KLF15, KLF16, SP1, SP3, SP4, SP8, SP9	NaN	KLF7, KLF10, KLF11, KLF17, KLF18	0.203764	0.00017	921168.667381	799834.304	293033.0	5901.0
dbcorrdb__POLR2A__ENCSR000EHP_1__m1	Topic8	PML, POLR2A, TAF1	BCLAF1, BRF1, CREB1, E2F6, ELF1, ELF2, ELK1, ELK3, ELK4, ETS1, ETV1, ETV5, ETV6, EZH2, GABPA, GABPB1, GTF2F1, HCFC1, MXI1, NR2C2, PHF8, SIN3A, XRCC4, ZNF143, ZNF274	NaN	FLI1	0.203731	0.000086	986222.195057	856338.854	420754.0	5647.0
taipale__ELK1_DBD_ACCGGAAGTN	Topic8	ELK1, ELK3, ETV1, ETV5	BCLAF1, ELF1, ELK4, ERF, ERG, ETS1, ETS2, ETV2, ETV3, ETV4, ETV6, FEV, FLI1, GABPA, GABPB1, SRF	NaN	ELF2, ETV3L, ETV7	0.203613	0.000177	999910.120792	868294.794	957838.0	3908.0
flyfactorsurvey__Bteb2_SOLEXA_2.5_FBgn0025679	Topic8	NaN	NaN	KLF15	SP1, SP2, SP3, SP4	0.203405	0.000069	905792.986004	786679.93	587514.0	4551.0
dbcorrdb__POLR2AphosphoS2__ENCSR000ECT_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.203341	0.000086	932784.879713	810158.252	302238.0	5621.0
cisbp__M6101	Topic8	TFAP2B, TFAP2C	TFAP2E	TFAP2A	TFAP2D	0.203245	0.00215	857523.013365	744839.902	854687.0	3169.0
transfac_pro__M03169	Topic8	NaN	NaN	NaN	NaN	0.203152	0.000176	970924.834069	843394.294	190728.0	6493.0
cisbp__M5856	Topic8	KLF14, KLF15, SP1, SP3, SP4, SP8, SP9	KLF10, KLF11, KLF13, KLF16, KLF2, KLF5, KLF6, KLF9, SP2	KLF17, KLF18	KLF12, KLF3, KLF7, KLF8, SP6, SP7	0.203148	0.000578	838028.331736	727956.084	283141.0	6210.0
idmmpmm__Mad	Topic8	NaN	NaN	SMAD1, SMAD5, SMAD9	NaN	0.203084	0.002245	829881.632077	720911.118	809920.0	3304.0
dbcorrdb__UBTF__ENCSR000EFW_1__m1	Topic8	UBTF	BRF1, ELF1, ESRRA, EZH2, GABPA, MXI1, PHF8, POLR2A, SIN3A, XRCC4, ZMIZ1, ZNF274	NaN	NaN	0.202951	0.000075	921928.719707	800945.724	262815.0	5740.0
cisbp__M5978	Topic8	ZNF740	NaN	NaN	NaN	0.202934	0.000816	849864.26844	738346.95	612133.0	4198.0
yetfasco__YHR056C_2164	Topic8	NaN	NaN	NaN	NaN	0.202818	0.000186	828472.00063	719819.476	505391.0	5116.0
scertf__zhao.YGR067C	Topic8	NaN	NaN	NaN	NaN	0.202649	0.00029	807818.616316	701956.672	744980.0	3825.0
dbcorrdb__POLR2AphosphoS2__ENCSR000DYF_1__m10	Topic8	BRF1, BRF2, CEBPB, CTCF, ESRRA, EZH2, HDAC2, MAZ, MXI1, NELFE, POLR2A, POLR3G, RAD21, RBBP5, SMARCA4, SP4, SREBF1, SREBF2, SUPT20H, TRIM28, XRCC4, ZMIZ1, ZNF274	ATF3, BCLAF1, BHLHE40, CREB1, E2F1, E2F6, EGR1, ELF1, ELK1, ELK4, ETS1, GABPA, HCFC1, HIC1, HMGN3, JUND, KAT2A, KLF5, MAX, MYC, NR2C2, NRF1, PHF8, RCOR1, SIN3A, SP1, SP2, SP3, TAF1, TFAP2A, TFAP2B, TFAP2C, UBTF, WT1, ZBTB7A, ZBTB7B, ZC3H11A, ZEB1, ZFX, ZNF143	NaN	ZFY	0.202511	0.000054	974847.760686	847178.546	118552.0	6720.0
swissregulon__sacCer__ASG1	Topic8	NaN	NaN	NaN	NaN	0.202455	0.000196	986800.69512	857599.482	422665.0	5664.0
predrem__nrMotif1895	Topic8	NaN	NaN	NaN	NaN	0.202365	0.000181	919063.271971	798780.384	326591.0	5666.0
cisbp__M0212	Topic8	NaN	NaN	TCFL5	BHLHE40	0.202271	0.001119	864424.205144	751341.44	512384.0	5122.0
tfdimers__MD00364	Topic8	WT1	NaN	NaN	NaN	0.202205	0.000727	877800.123692	763002.586	455827.0	4983.0
dbcorrdb__POLR2A__ENCSR000FAY_1__m2	Topic8	POLR2A	NaN	NaN	NaN	0.202119	0.000655	945397.93103	821808.602	501203.0	4947.0
dbcorrdb__POLR2A__ENCSR000EAJ_1__m1	Topic8	POLR2A	ELK1, ELK4, ETV5, TAF1	NaN	NaN	0.202047	0.000365	933014.410793	811084.694	317058.0	5663.0
taipale_cyt_meth__ETV1_NACCGGAWGTN_eDBD	Topic8	ELK1, ELK4, ETV1, ETV4, ETV5, GABPA	BCLAF1, ELF1, ELK3, ERF, ERG, ETS1, ETS2, ETV2, ETV3, FEV, FLI1, GABPB1, POLR2A, SRF, TAF1	NaN	ETV3L, ETV6, ETV7	0.201847	0.000407	905813.659312	787547.466	979960.0	3184.0
transfac_pro__M00341	Topic8	GABPA, GABPB1	BCLAF1, EGR1, ELF1, ELK1, ELK3, ELK4, ERF, ERG, ETS1, ETV1, ETV2, ETV3, ETV4, ETV5, FEV, FLI1, PML	NaN	ETS2, ETV6, ETV7	0.201788	0.000156	863733.863195	750992.432	411544.0	5766.0
elemento__CGGGAGC	Topic8	NaN	NaN	NaN	NaN	0.201635	0.000473	864644.709368	751864.47	522476.0	4506.0
elemento__ACCCCGC	Topic8	NaN	NaN	NaN	NaN	0.201607	0.00008	886062.670281	770503.61	420948.0	5114.0
transfac_pro__M05938	Topic8	ZNF714	NaN	NaN	NaN	0.201575	0.000227	966103.733451	840124.416	227310.0	6332.0
swissregulon__sacCer__MIG3	Topic8	NaN	NaN	EGR1, EGR2, EGR3, EGR4, WT1	NaN	0.201347	0.000636	957308.821964	832608.022	594655.0	4720.0
scertf__spivak.ERT1	Topic8	NaN	NaN	NaN	NaN	0.201324	0.000155	884930.358089	769670.102	681601.0	4248.0
cisbp__M1766	Topic8	NaN	NaN	NaN	NaN	0.201233	0.000217	902671.046274	785149.622	714280.0	4505.0
transfac_pro__M02773	Topic8	NaN	KLF14, KLF16, KLF4, KLF5, SP1	KLF7	KLF12, KLF3, KLF6, KLF8, SP2, SP3, SP4	0.200981	0.000274	873742.176901	760119.79	510930.0	4810.0
flyfactorsurvey__l_3_neo38_SOLEXA_F2-4	Topic8	NaN	KLF16, REST	NaN	WT1	0.200888	0.001095	863747.566007	751473.1	689038.0	3874.0
cisbp__M0700	Topic8	ELK1, ELK3, ELK4, ERG, ETV1, ETV2, FEV, FLI1, GABPA	BCLAF1, ELF1, ELF2, ELF4, ERF, ETS1, ETS2, ETV3, ETV5, GABPB1, POLR2A, SRF	ETV4	ETV3L, ETV6, ETV7	0.200882	0.000323	913247.356449	794542.292	879910.0	3743.0
transfac_pro__M05041	Topic8	NaN	NaN	NaN	NaN	0.200855	0.0001	1021123.916278	888413.49	267153.0	6441.0
dbcorrdb__CHD2__ENCSR000EBT_1__m2	Topic8	CHD2, FOS, NFYA, PBX3, SP1	E2F4, IRF3, NFYB, NFYC, RFX5, ZNF274	NaN	NaN	0.200839	0.000416	890445.994704	774727.53	245272.0	6345.0
cisbp__M1784	Topic8	NaN	NaN	NaN	NaN	0.200718	0.00009	888054.256084	772711.372	727557.0	4294.0
transfac_pro__M09005	Topic8	SP1	FOS, IRF1, KLF1, KLF12, KLF13, KLF14, KLF15, KLF16, KLF3, KLF4, KLF5, KLF9, NFYA, NFYB, PBX3, SP2, SP3, SP8, SP9, STAT1	SP4, SP6, SP7	KLF10, KLF11, KLF17, KLF18, KLF6, KLF7, KLF8	0.200403	0.000123	852397.96293	741848.384	137072.0	7002.0
predrem__nrMotif2510	Topic8	NaN	NaN	NaN	NaN	0.200276	0.000449	883687.54142	769147.592	392536.0	5134.0
dbcorrdb__MYC__ENCSR000DMQ_1__m1	Topic8	ATF3, BHLHE40, E2F6, EZH2, MAX, MXI1, MYC	BRF1, BRF2, CEBPB, CTCF, ELK1, ESRRA, GABPA, HCFC1, HDAC2, KDM5A, MYCN, NELFE, NFE2, POLR2A, POLR3G, RAD21, RBBP5, SAP30, SIN3A, SMARCA4, SP4, SREBF1, SREBF2, SUPT20H, TAF1, USF1, USF2, XRCC4, YY1, ZMIZ1, ZNF274	NaN	CLOCK, NPAS2	0.200204	0.000664	953551.886773	829998.048	372176.0	5606.0
homer__GGCGGGAARN_E2F6	Topic8	E2F6	NaN	NaN	NaN	0.200012	0.001464	827636.664355	720493.592	903482.0	3250.0

This table can also be easily exported to a html file:

[23]:

for key in DEM_dict.motif_enrichment.keys():
    out_file = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/topics/DEM/'+ str(key) + '.html'
    DEM_dict.motif_enrichment[key].to_html(open(out_file, 'w'), escape=False, col_space=80)

2. Deriving cistromes using DARs

A. Loading your region sets

pycisTarget uses as input a dictionary containing the region set name as label and regions (as pyranges) as values. We will start by loading the binarized topics (see pycisTopic - Single sample workfllow tutorial).

[68]:

# Load region DARs topics
import pickle
infile = open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistopic/DARs/DARs.pkl', 'rb')
DARs_dict = pickle.load(infile)
infile.close()

[69]:

import pyranges as pr
from pycistarget.utils import *
region_sets = {key: pr.PyRanges(region_names_to_coordinates(DARs_dict[key].index.tolist())) for key in DARs_dict.keys()}

B. cisTarget

We run cisTarget with same settings as before, and using the previously created database.

[70]:

# Load cistarget functions
from pycistarget.motif_enrichment_cistarget import *

[71]:

# Preload db, you can also just provide the path to the db. Preloading the database is useful if you want to test different parameters.
# This will take some time depending on the size of your database
db = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/dbs/human_brain.regions_vs_motifs.rankings.feather'
ctx_db = cisTargetDatabase(db, region_sets)
# Remove dbcorr motifs
ctx_db.db_rankings = ctx_db.db_rankings[~ctx_db.db_rankings.index.str.contains("dbcorr")]

2021-08-12 16:51:03,626 cisTarget    INFO     Reading cisTarget database

[72]:

# Run
cistarget_dict = run_cistarget(ctx_db = ctx_db,
                               region_sets = region_sets,
                               specie = 'homo_sapiens',
                               annotation_version = 'v9nr_clust',
                               path_to_motif_annotations = '/staging/leuven/stg_00002/lcb/cbravo/motif_clustering/RNA_harmony_snn_res_5_clusters/motif_collection_combined_motifs_stamp_and_singlets/hs_annotation.tsv',
                               auc_threshold = 0.005,
                               nes_threshold = 3.0,
                               rank_threshold = 0.05,
                               annotation = ['Direct_annot', 'Orthology_annot'],
                               n_cpu = 1,
                               _temp_dir='/scratch/leuven/313/vsc31305/ray_spill')

2021-08-12 17:25:05,575 cisTarget    INFO     Running cisTarget for AST which has 32163 regions
2021-08-12 17:25:24,243 cisTarget    INFO     Annotating motifs for AST
2021-08-12 17:25:28,992 cisTarget    INFO     Getting cistromes for AST
2021-08-12 17:25:29,750 cisTarget    INFO     Running cisTarget for BG which has 32515 regions
2021-08-12 17:25:49,379 cisTarget    INFO     Annotating motifs for BG
2021-08-12 17:25:54,103 cisTarget    INFO     Getting cistromes for BG
2021-08-12 17:25:54,859 cisTarget    INFO     Running cisTarget for COP which has 23169 regions
2021-08-12 17:26:06,990 cisTarget    INFO     Annotating motifs for COP
2021-08-12 17:26:09,445 cisTarget    INFO     Getting cistromes for COP
2021-08-12 17:26:09,715 cisTarget    INFO     Running cisTarget for ENDO which has 15280 regions
2021-08-12 17:26:18,714 cisTarget    INFO     Annotating motifs for ENDO
2021-08-12 17:26:20,518 cisTarget    INFO     Getting cistromes for ENDO
2021-08-12 17:26:20,807 cisTarget    INFO     Running cisTarget for GC which has 15962 regions
2021-08-12 17:26:29,586 cisTarget    INFO     Annotating motifs for GC
2021-08-12 17:26:31,662 cisTarget    INFO     Getting cistromes for GC
2021-08-12 17:26:31,901 cisTarget    INFO     Running cisTarget for GP which has 16659 regions
2021-08-12 17:26:41,414 cisTarget    INFO     Annotating motifs for GP
2021-08-12 17:26:43,545 cisTarget    INFO     Getting cistromes for GP
2021-08-12 17:26:43,807 cisTarget    INFO     Running cisTarget for INH_PVALB which has 17017 regions
2021-08-12 17:26:53,256 cisTarget    INFO     Annotating motifs for INH_PVALB
2021-08-12 17:26:55,436 cisTarget    INFO     Getting cistromes for INH_PVALB
2021-08-12 17:26:55,701 cisTarget    INFO     Running cisTarget for INH_SNCG which has 18492 regions
2021-08-12 17:27:05,715 cisTarget    INFO     Annotating motifs for INH_SNCG
2021-08-12 17:27:07,783 cisTarget    INFO     Getting cistromes for INH_SNCG
2021-08-12 17:27:08,039 cisTarget    INFO     Running cisTarget for INH_SST which has 17845 regions
2021-08-12 17:27:17,272 cisTarget    INFO     Annotating motifs for INH_SST
2021-08-12 17:27:19,371 cisTarget    INFO     Getting cistromes for INH_SST
2021-08-12 17:27:19,622 cisTarget    INFO     Running cisTarget for INH_VIP which has 19186 regions
2021-08-12 17:27:29,471 cisTarget    INFO     Annotating motifs for INH_VIP
2021-08-12 17:27:31,710 cisTarget    INFO     Getting cistromes for INH_VIP
2021-08-12 17:27:31,954 cisTarget    INFO     Running cisTarget for MG which has 31580 regions
2021-08-12 17:27:49,720 cisTarget    INFO     Annotating motifs for MG
2021-08-12 17:27:54,202 cisTarget    INFO     Getting cistromes for MG
2021-08-12 17:27:54,935 cisTarget    INFO     Running cisTarget for MGL which has 10216 regions
2021-08-12 17:28:02,292 cisTarget    INFO     Annotating motifs for MGL
2021-08-12 17:28:04,269 cisTarget    INFO     Getting cistromes for MGL
2021-08-12 17:28:04,581 cisTarget    INFO     Running cisTarget for MOL which has 29830 regions
2021-08-12 17:28:19,019 cisTarget    INFO     Annotating motifs for MOL
2021-08-12 17:28:21,794 cisTarget    INFO     Getting cistromes for MOL
2021-08-12 17:28:22,167 cisTarget    INFO     Running cisTarget for NFOL which has 25974 regions
2021-08-12 17:28:34,660 cisTarget    INFO     Annotating motifs for NFOL
2021-08-12 17:28:37,189 cisTarget    INFO     Getting cistromes for NFOL
2021-08-12 17:28:37,472 cisTarget    INFO     Running cisTarget for OPC which has 14704 regions
2021-08-12 17:28:46,374 cisTarget    INFO     Annotating motifs for OPC
2021-08-12 17:28:48,512 cisTarget    INFO     Getting cistromes for OPC
2021-08-12 17:28:49,049 cisTarget    INFO     Running cisTarget for PURK which has 19586 regions
2021-08-12 17:28:59,727 cisTarget    INFO     Annotating motifs for PURK
2021-08-12 17:29:01,966 cisTarget    INFO     Getting cistromes for PURK
2021-08-12 17:29:02,225 cisTarget    INFO     Done!

[73]:

# Save
import pickle
with open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/DARs/DARs_cistarget_dict.pkl', 'wb') as f:
  pickle.dump(cistarget_dict, f)

We can load the results for exploration.

[74]:

# Load
import pickle
infile = open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/DARs/DARs_cistarget_dict.pkl', 'rb')
cistarget_dict = pickle.load(infile)
infile.close()

To visualize motif enrichment results, we can use the cisTarget_results() function:

[96]:

cistarget_results(cistarget_dict, name='COP')

[96]:

	Region_set	Direct_annot	Orthology_annot	NES	AUC	Rank_at_max	Motif_hits
metacluster_46.3	COP	SOX10, SOX8	NaN	18.620411	0.014769	21274.0	3051
hocomoco__SOX9_HUMAN.H11MO.0.B	COP	SOX9	NaN	16.817214	0.013573	21643.0	3073
metacluster_46.1	COP	SOX11, SOX3, SRY, SOX17, SOX13, SOX1, SOX9, SOX15, SOX18, SOX21, SOX2, SOX30, SOX6, SOX8, SOX10, SOX5, SOX7, SOX4, HBP1	SOX14, SOX21, SOX17	16.407962	0.013302	21771.0	3283
metacluster_2.93	COP	SOX9, SOX18, SOX4, SOX17	NaN	14.233799	0.011860	21777.0	2999
transfac_pro__M08972	COP	SOX17	NaN	13.963742	0.011680	21789.0	2779
factorbook__SOX2	COP	SOX2	NaN	13.838165	0.011597	21708.0	2624
homer__CCATTGTTNY_Sox6	COP	NaN	SOX6	13.176417	0.011158	21781.0	2932
cisbp__M5208	COP	NaN	SOX18, SOX7, SOX17	12.302875	0.010579	21673.0	2650
transfac_pro__M01308	COP	SOX4	NaN	12.171386	0.010492	21786.0	2669
cisbp__M1904	COP	SOX9	NaN	11.924563	0.010328	21790.0	2628
jaspar__MA0515.1	COP	NaN	SOX6	11.782889	0.010234	21552.0	2466
swissregulon__hs__SOX_8_9_10_.p2	COP	SOX9, SOX10, SOX8	NaN	11.319107	0.009926	21778.0	2482
swissregulon__hs__SOX2.p2	COP	SOX2	NaN	11.239222	0.009873	21766.0	2446
taipale_cyt_meth__SOX14_NGAACAATGN_eDBD_meth	COP	NaN	NaN	11.160830	0.009821	21784.0	2535
transfac_public__M00410	COP	SOX9	NaN	10.730375	0.009536	21784.0	2490
metacluster_46.17	COP	SOX15, SOX11, SOX12, SOX14, SOX18, SOX5, SOX21, SOX3, SRY, SOX2, SOX6, SOX13, SMAD1, SOX8, SOX4, SOX9, SOX10	SOX3, SOX6, SOX2, SOX4, FOXJ3, SOX10	10.545041	0.009413	21780.0	2705
transfac_pro__M07338	COP	SOX10	NaN	10.028370	0.009070	21788.0	2639
jaspar__MA0143.3	COP	NaN	NaN	9.261083	0.008561	21776.0	2146
tfdimers__MD00293	COP	SMAD1, SOX4	NaN	8.947037	0.008353	21760.0	2475
metacluster_46.18	COP	SOX15, NANOG, SOX5, SOX18, SOX14, SOX3, SRY, SOX17, SOX30, SOX13, SOX2, SOX6, SOX9, SOX8	SOX15, SOX12, SOX14, SOX7, SOX18, SOX21, NANOGP8, SRY, SOX17, SOX2, SOX30, SOX11	8.930642	0.008342	21756.0	2736
metacluster_46.2	COP	SOX7, SOX17, SOX10, SRY	NaN	8.520196	0.008070	21648.0	2148
metacluster_46.19	COP	NaN	SOX5	8.200207	0.007858	21784.0	2127
cisbp__M5207	COP	NaN	SOX11, SOX12, SOX4	7.987817	0.007717	21783.0	2204
metacluster_46.8	COP	SOX15, SOX9, HNF4G	SOX11, SOX12, SOX4	7.562618	0.007435	21786.0	2232
metacluster_1.73	COP	SOX5, SOX6	NaN	6.966808	0.007040	21763.0	2277
transfac_public__M00042	COP	SOX5	NaN	6.406148	0.006668	21787.0	2097
metacluster_49.30	COP	SOX5	SOX13, SOX5	6.171868	0.006512	21776.0	2033
hocomoco__SOX9_MOUSE.H11MO.1.A	COP	NaN	SOX9	5.876397	0.006316	21779.0	2204
taipale_cyt_meth__SOX14_CCGAACAATN_FL_meth	COP	SOX14	NaN	5.845309	0.006296	21787.0	2064
taipale_cyt_meth__SOX12_ACCGAACAATN_eDBD_meth	COP	NaN	NaN	5.776563	0.006250	21610.0	1971
metacluster_61.1	COP	SOX3, POLR2A	SOX14	5.293787	0.005930	21693.0	1996
hocomoco__SOX2_HUMAN.H11MO.0.A	COP	SOX2	NaN	5.268134	0.005913	21686.0	2122
metacluster_46.35	COP	NaN	NaN	5.251500	0.005902	21785.0	1827
hocomoco__SOX4_HUMAN.H11MO.0.B	COP	SOX4	NaN	4.909293	0.005675	21789.0	2109
metacluster_46.21	COP	SOX14, SOX12	NaN	4.889821	0.005662	21786.0	2008
tfdimers__MD00291	COP	YY2, FOXO1	NaN	4.842816	0.005631	21761.0	1852
taipale_cyt_meth__BHLHA15_NMCAGCTGKN_eDBD_meth	COP	NaN	NaN	4.569952	0.005450	20076.0	1656
swissregulon__hs__SRY.p2	COP	SRY	NaN	4.539013	0.005429	21761.0	1911
metacluster_46.22	COP	SOX17	SOX12, SOX5, SRY, SOX30, SOX4, SOX8	4.494009	0.005399	21749.0	2332
metacluster_46.26	COP	NaN	NaN	4.469520	0.005383	21777.0	1809
transfac_pro__M02101	COP	MYOG	NaN	4.402984	0.005339	21312.0	1726
transfac_pro__M01288	COP	NEUROD1	NaN	4.179903	0.005191	21737.0	1767
taipale_tf_pairs__SOX6_CACCGAACAAT_HT	COP	SOX6	NaN	4.156788	0.005176	21774.0	1766
cisbp__M1601	COP	NaN	SOX11	4.154369	0.005174	21757.0	2195
elemento__CAGCTGCA	COP	NaN	NaN	4.110022	0.005145	21644.0	1689
taipale_cyt_meth__MSC_NNACAGCTGTNN_FL_repr	COP	MSC	NaN	4.021894	0.005086	21786.0	1706
tfdimers__MD00591	COP	SRY, TFAP2C	NaN	4.009351	0.005078	20834.0	1710
metacluster_14.21	COP	SOX18	NaN	3.916416	0.005016	21789.0	1736
metacluster_27.27	COP	TCF12, MYOD1, TFAP4, TCF3	ASCL1, MYOD1, HES4, ASCL2, TCF12, MYF5, TCF3, TCF4, HES1	3.885895	0.004996	21407.0	1696
homer__AACAGCTGTTHN_E-box	COP	NaN	NaN	3.863079	0.004981	21672.0	1648
metacluster_27.23	COP	TCF12	NaN	3.763574	0.004915	18001.0	1431
metacluster_27.25	COP	OLIG3, MYOG, MYF6, ZBTB18, PTF1A, OLIG2, TCF21, ASCL1, MYOD1, TFAP4, ASCL2, MSC, TCF3, TCF4, FERD3L, SIN3A, ATOH1, BHLHA15, TCF12, MYF5, NEUROG2	MYOD1, MYOG, TFAP4, MYF6, TAL1, ATOH1, ASCL2, PTF1A, TCF12, MYF5, TCF3, TCF21, TCF4	3.672758	0.004855	21645.0	1814
transfac_pro__M02907	COP	NaN	SOX21	3.663889	0.004849	21773.0	1998
cisbp__M5671	COP	NHLH1	NaN	3.649435	0.004839	17631.0	1366
flyfactorsurvey__Hth_Cell_FBgn0001235	COP	NaN	MEIS2	3.592783	0.004802	21537.0	1588
taipale__NHLH1_full_CGCAGCTGCG	COP	NHLH1	NaN	3.572237	0.004788	21307.0	1591
metacluster_1.72	COP	SRY	IRX5, IRX2, IRX6, IRX4, IRX1, IRX3	3.555633	0.004777	21715.0	1830
taipale_tf_pairs__SOX17_ACCGAACAAT_HT	COP	SOX17	NaN	3.543180	0.004769	21038.0	1686
hocomoco__ANDR_HUMAN.H11MO.2.A	COP	AR	NaN	3.527233	0.004758	19064.0	1449
jaspar__MA0499.1	COP	NaN	MYOD1	3.524336	0.004756	21725.0	1602
tfdimers__MD00167	COP	HIC1, MAFA	NaN	3.523739	0.004756	20108.0	1558
cisbp__M5869	COP	SRY	NaN	3.503222	0.004742	14487.0	1130
hdpi__ZNF238	COP	ZBTB18	NaN	3.488589	0.004733	21418.0	1667
taipale_cyt_meth__MSC_NRACAGCTGTYN_eDBD	COP	MSC	NaN	3.436298	0.004698	21279.0	1617
metacluster_77.9	COP	NHLH2, NHLH1, TFAP4	NHLH2, NHLH1, ASCL1	3.417036	0.004685	15403.0	1200
factorbook__TCF12	COP	TCF12	NaN	3.398700	0.004673	21241.0	1618
metacluster_49.23	COP	NaN	NaN	3.255832	0.004578	11712.0	924
taipale__SOX2_full_NAACAATANCATTGTTN	COP	SOX2	NaN	3.232031	0.004562	7821.0	628
metacluster_45.15	COP	TAL1	ATOH1	3.207841	0.004546	13342.0	1003
transfac_pro__M02807	COP	NaN	NaN	3.178186	0.004527	21735.0	1973
cisbp__M2944	COP	TFAP4	NaN	3.159313	0.004514	18290.0	1476
metacluster_45.5	COP	OLIG2	NaN	3.157103	0.004513	21286.0	1528
taipale__SOX18_full_AACAATNNCATTGTT	COP	SOX18	NaN	3.124880	0.004491	5618.0	459
metacluster_9.78	COP	NaN	NaN	3.109888	0.004481	17751.0	1308
taipale_cyt_meth__ZBTB18_NWTCCAGATGTKN_eDBD_meth_repr	COP	NaN	NaN	3.079756	0.004461	21790.0	1608
metacluster_46.6	COP	NaN	NaN	3.044427	0.004438	17137.0	1334
metacluster_2.195	COP	NaN	NaN	3.014952	0.004418	6532.0	519
metacluster_27.26	COP	MYF6	ASCL1, ASCL2	3.012921	0.004417	21028.0	1573
metacluster_42.41	COP	NaN	NaN	3.007247	0.004413	21264.0	1505

[94]:

for key in cistarget_dict.keys():
    out_file = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/DARs/cistarget/'+ str(key) + '.html'
    cistarget_dict[key].motif_enrichment.to_html(open(out_file, 'w'), escape=False, col_space=80)

C. DEM

As we showed before, we can also use DARs as input for DEM.

[ ]:

# Load DEM functions
from pycistarget.motif_enrichment_dem import *

[ ]:

# Preload db, you can also just provide the path to the db. Preloading the database is useful if you want to test different parameters.
db = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/dbs/human_brain.regions_vs_motifs.scores.feather'
dem_db = DEMDatabase(db, region_sets)
# Run (r23i27n24)
DEM_dict = DEM(dem_db = dem_db,
    region_sets = region_sets,
    specie = 'homo_sapiens',
    contrasts = 'Other',
    name = 'DEM',
    fraction_overlap = 0.4,
    max_bg_regions = None,
    adjpval_thr = 0.05,
    log2fc_thr = 0.25,
    mean_fg_thr = 0,
    motif_hit_thr = None,
    cluster_buster_path = None,
    path_to_genome_fasta = None,
    path_to_motifs = None,
    annotation = ['Direct_annot', 'Motif_similarity_annot', 'Orthology_annot', 'Motif_similarity_and_Orthology_annot'],
    n_cpu = 1,
    tmp_dir = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/pycistarget/tmp')

[ ]:

# Save
import pickle
with open('/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/DARs/DARs_DEM_dict.pkl', 'wb') as f:
  pickle.dump(DEM_dict, f)

[ ]:

for key in DEM_dict.motif_enrichment.keys():
    out_file = '/staging/leuven/stg_00002/lcb/cbravo/Multiomics_pipeline/analysis/10x_multiome_brain/output/atac/pycistarget/DARs/DEM/'+ str(key) + '.html'
    DEM_dict.motif_enrichment[key].to_html(open(out_file, 'w'), escape=False, col_space=80)